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Aliases for LPCAT3 Gene

Aliases for LPCAT3 Gene

  • Lysophosphatidylcholine Acyltransferase 3 2 3 4 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 5 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 5 2 3
  • Membrane Bound O-Acyltransferase Domain Containing 5 2 3
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • O-Acyltransferase Domain-Containing Protein 5 3 4
  • 1-Acylglycerophosphoserine O-Acyltransferase 3 4
  • Lysophosphatidylserine Acyltransferase 3 4
  • Lyso-PC Acyltransferase 3 3 4
  • Lyso-PS Acyltransferase 3 4
  • LPLAT 5 3 4
  • MBOAT5 3 4
  • Lpcat 3 4
  • OACT5 3 4
  • LPSAT 3 4
  • Lysophosphatidylcholine Acyltransferase 4
  • Lysophospholipid Acyltransferase 5 3
  • Putative Protein Similar To Nessy 3
  • Lyso-PC Acyltransferase 4
  • EC 2.3.1.23 4
  • EC 2.3.1.n6 4
  • EC 2.3.1.- 4
  • Nessy 3
  • C3F 3

External Ids for LPCAT3 Gene

Previous HGNC Symbols for LPCAT3 Gene

  • OACT5
  • MBOAT5

Previous GeneCards Identifiers for LPCAT3 Gene

  • GC12M006958
  • GC12M007085

Summaries for LPCAT3 Gene

GeneCards Summary for LPCAT3 Gene

LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Metabolism and triacylglycerol biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is MBOAT1.

UniProtKB/Swiss-Prot for LPCAT3 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Gene Wiki entry for LPCAT3 Gene

Additional gene information for LPCAT3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPCAT3 Gene

Genomics for LPCAT3 Gene

GeneHancer (GH) Regulatory Elements for LPCAT3 Gene

Promoters and enhancers for LPCAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I007016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 325 2.7 HDGF SMAD1 SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 ZNF143 FOS GC12M007017 LPCAT3 PIR59434 ZNF384 NOP2 ENSG00000219410 ENSG00000247853 SCARNA12 ENSG00000256967 C1RL-AS1
GH12I006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.1 +64.9 64880 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 SCARNA12 ENSG00000256967 NCAPD2
GH12I007059 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.4 -42.2 -42229 2.5 FOXA2 ARID4B SIN3A YY1 ARID2 RXRA NCOA1 MXD4 REST KAT8 GC12P007517 GC12P007522 GC12P007527 GC12P007530 GC12P007532 PIR40185 PIR45028 PIR53702 PIR61112 PIR50287
GH12I006344 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +671.9 671929 3.6 PKNOX1 SMAD1 ATF1 ARNT SIN3A BRCA1 NCOA2 TCF12 GATA2 ATF7 GC12P006346 CHD4 ENSG00000219410 ZNF384 ENSG00000247853 PHB2 LTBR SCNN1A VAMP1 C1RL-AS1
GH12I006967 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.3 +48.6 48621 5.4 FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 EMG1 PHB2 ZNF384 CHD4 ENSG00000247853 NOP2 ENSG00000219410 SCARNA12 GDF3 LPCAT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LPCAT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LPCAT3 gene promoter:

Genomic Locations for LPCAT3 Gene

Genomic Locations for LPCAT3 Gene
chr12:6,976,185-7,018,538
(GRCh38/hg38)
Size:
42,354 bases
Orientation:
Minus strand
chr12:7,085,347-7,125,842
(GRCh37/hg19)

Genomic View for LPCAT3 Gene

Genes around LPCAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT3 Gene

Proteins for LPCAT3 Gene

  • Protein details for LPCAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1A2-MBOA5_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 5
    Protein Accession:
    Q6P1A2
    Secondary Accessions:
    • B2RDH0
    • B7Z3N3
    • Q7KZS1
    • Q92980
    • Q9BW40

    Protein attributes for LPCAT3 Gene

    Size:
    487 amino acids
    Molecular mass:
    56035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB51326.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC51640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LPCAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPCAT3 Gene

Post-translational modifications for LPCAT3 Gene

Other Protein References for LPCAT3 Gene

No data available for DME Specific Peptides for LPCAT3 Gene

Domains & Families for LPCAT3 Gene

Gene Families for LPCAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for LPCAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P1A2

UniProtKB/Swiss-Prot:

MBOA5_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization.
  • Belongs to the membrane-bound acyltransferase family.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with LPCAT3: view

Function for LPCAT3 Gene

Molecular function for LPCAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41.29 uM for palmitoyl-CoA {ECO:0000269 PubMed:18195019}; KM=36.65 uM for stearoyl-CoA {ECO:0000269 PubMed:18195019}; KM=72.68 uM for oleoyl-CoA {ECO:0000269 PubMed:18195019}; KM=201.4 uM for linoleoyl-CoA {ECO:0000269 PubMed:18195019}; KM=71.56 uM for arachidonoyl-CoA {ECO:0000269 PubMed:18195019}; KM=72.19 uM for 1-palmitoyl-lysophosphatidylcholine {ECO:0000269 PubMed:18195019}; Vmax=1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=18148 nmol/min/mg enzyme with linoleoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by thimerosal.
UniProtKB/Swiss-Prot Function:
Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for LPCAT3 Gene

Phenotypes From GWAS Catalog for LPCAT3 Gene

Gene Ontology (GO) - Molecular Function for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity IMP 22511767
genes like me logo Genes that share ontologies with LPCAT3: view
genes like me logo Genes that share phenotypes with LPCAT3: view

Animal Models for LPCAT3 Gene

MGI Knock Outs for LPCAT3:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPCAT3 Gene

Localization for LPCAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPCAT3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPCAT3 Gene

Pathways & Interactions for LPCAT3 Gene

genes like me logo Genes that share pathways with LPCAT3: view

Pathways by source for LPCAT3 Gene

UniProtKB/Swiss-Prot Q6P1A2-MBOA5_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036150 phosphatidylserine acyl-chain remodeling TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for SIGNOR curated interactions for LPCAT3 Gene

Drugs & Compounds for LPCAT3 Gene

(3) Drugs for LPCAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0

(70) Additional Compounds for LPCAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LPCAT3: view

Transcripts for LPCAT3 Gene

Unigene Clusters for LPCAT3 Gene

Lysophosphatidylcholine acyltransferase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LPCAT3 Gene

GeneLoc Exon Structure for
LPCAT3
ECgene alternative splicing isoforms for
LPCAT3

Expression for LPCAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPCAT3 Gene

Protein differential expression in normal tissues from HIPED for LPCAT3 Gene

This gene is overexpressed in Nasal epithelium (34.6) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LPCAT3 Gene



Protein tissue co-expression partners for LPCAT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LPCAT3 Gene:

LPCAT3

SOURCE GeneReport for Unigene cluster for LPCAT3 Gene:

Hs.655248

mRNA Expression by UniProt/SwissProt for LPCAT3 Gene:

Q6P1A2-MBOA5_HUMAN
Tissue specificity: Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils.

Evidence on tissue expression from TISSUES for LPCAT3 Gene

  • Blood(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with LPCAT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPCAT3 Gene

Orthologs for LPCAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPCAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPCAT3 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia LPCAT3 33 34
  • 91.84 (n)
rat
(Rattus norvegicus)
Mammalia Lpcat3 33
  • 87.95 (n)
mouse
(Mus musculus)
Mammalia Lpcat3 33 16 34
  • 87.75 (n)
cow
(Bos Taurus)
Mammalia LPCAT3 33 34
  • 87.29 (n)
oppossum
(Monodelphis domestica)
Mammalia LPCAT3 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT3 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPCAT3 33 34
  • 72.15 (n)
lizard
(Anolis carolinensis)
Reptilia LPCAT3 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat3 33
  • 68.2 (n)
zebrafish
(Danio rerio)
Actinopterygii lpcat3 33 34
  • 63.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta nes 33 34
  • 50.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012258 33
  • 49.43 (n)
worm
(Caenorhabditis elegans)
Secernentea mboa-6 33 34
  • 45.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9665 34
  • 38 (a)
OneToOne
Species where no ortholog for LPCAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LPCAT3 Gene

ENSEMBL:
Gene Tree for LPCAT3 (if available)
TreeFam:
Gene Tree for LPCAT3 (if available)

Paralogs for LPCAT3 Gene

Paralogs for LPCAT3 Gene

Pseudogenes.org Pseudogenes for LPCAT3 Gene

genes like me logo Genes that share paralogs with LPCAT3: view

Variants for LPCAT3 Gene

Sequence variations from dbSNP and Humsavar for LPCAT3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000224637 -- 6,982,231(-) G/A/T intron_variant
rs1000241626 -- 6,989,889(-) T/A intron_variant
rs1000343388 -- 7,015,093(-) G/C intron_variant
rs1000388112 -- 6,996,876(-) G/A intron_variant
rs1000501528 -- 6,988,333(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LPCAT3 Gene

Variant ID Type Subtype PubMed ID
nsv513353 CNV insertion 21212237
nsv513352 CNV insertion 21212237
nsv509453 CNV insertion 20534489
nsv480390 CNV novel sequence insertion 20440878
nsv1047373 CNV gain 25217958
nsv1039509 CNV gain 25217958
nsv1035811 CNV gain 25217958
esv3628412 CNV loss 21293372
esv2579054 CNV insertion 19546169
esv1188372 CNV insertion 17803354

Variation tolerance for LPCAT3 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.28; 90.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPCAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPCAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT3 Gene

Disorders for LPCAT3 Gene

Additional Disease Information for LPCAT3

No disorders were found for LPCAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPCAT3 Gene

Publications for LPCAT3 Gene

  1. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. (PMID: 18195019) Zhao Y … Cao G (The Journal of biological chemistry 2008) 2 3 4 58
  2. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 2 3 4 58
  3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PMID: 18772128) Gijón MA … Voelker DR (The Journal of biological chemistry 2008) 3 4 58
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for LPCAT3 Gene

Sources for LPCAT3 Gene

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