Aliases for LPCAT3 Gene

Aliases for LPCAT3 Gene

  • Lysophosphatidylcholine Acyltransferase 3 2 3 4 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 5 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 5 2 3
  • Membrane Bound O-Acyltransferase Domain Containing 5 2 3
  • 1-Acylglycerophosphoethanolamine O-Acyltransferase 3 4
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • O-Acyltransferase Domain-Containing Protein 5 3 4
  • 1-Acylglycerophosphoserine O-Acyltransferase 3 4
  • Lysophosphatidylserine Acyltransferase 3 4
  • Lysophospholipid Acyltransferase 5 3 4
  • Lyso-PC Acyltransferase 3 3 4
  • Lyso-PS Acyltransferase 3 4
  • LPLAT 5 3 4
  • MBOAT5 3 4
  • LPCAT 3 4
  • LPSAT 3 4
  • OACT5 3 4
  • Nessy 2 3
  • C3F 2 3
  • Lysophosphatidylcholine Acyltransferase 4
  • Putative Protein Similar To Nessy 3
  • Lyso-PC Acyltransferase 4
  • EC 2.3.1.23 4
  • EC 2.3.1.n7 4
  • EC 2.3.1.n6 4
  • EC 2.3.1.- 4
  • LPCAT3 5

External Ids for LPCAT3 Gene

Previous HGNC Symbols for LPCAT3 Gene

  • OACT5
  • MBOAT5

Previous GeneCards Identifiers for LPCAT3 Gene

  • GC12M006958
  • GC12M007085

Summaries for LPCAT3 Gene

GeneCards Summary for LPCAT3 Gene

LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) is a Protein Coding gene. Diseases associated with LPCAT3 include Retinitis Pigmentosa 40 and Fanconi Anemia, Complementation Group D2. Among its related pathways are Acyl chain remodelling of PE and Ferroptosis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is MBOAT2.

UniProtKB/Swiss-Prot Summary for LPCAT3 Gene

  • Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18782225, PubMed:18195019, PubMed:18772128). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18782225, PubMed:18195019, PubMed:18772128). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity).

Gene Wiki entry for LPCAT3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPCAT3 Gene

Genomics for LPCAT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LPCAT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPCAT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPCAT3

Top Transcription factor binding sites by QIAGEN in the LPCAT3 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXL1
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • HNF-4alpha2
  • Msx-1

Genomic Locations for LPCAT3 Gene

Latest Assembly
chr12:6,976,185-7,018,508
(GRCh38/hg38)
Size:
42,324 bases
Orientation:
Minus strand

Previous Assembly
chr12:7,085,347-7,125,780
(GRCh37/hg19 by Entrez Gene)
Size:
40,434 bases
Orientation:
Minus strand

chr12:7,085,348-7,125,814
(GRCh37/hg19 by Ensembl)
Size:
40,467 bases
Orientation:
Minus strand

Genomic View for LPCAT3 Gene

Genes around LPCAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT3 Gene

Proteins for LPCAT3 Gene

  • Protein details for LPCAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1A2-MBOA5_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 5
    Protein Accession:
    Q6P1A2
    Secondary Accessions:
    • B2RDH0
    • B7Z3N3
    • Q7KZS1
    • Q92980
    • Q9BW40

    Protein attributes for LPCAT3 Gene

    Size:
    487 amino acids
    Molecular mass:
    56035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB51326.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC51640.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG37917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for LPCAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPCAT3 Gene

Post-translational modifications for LPCAT3 Gene

  • Ubiquitination at Lys175
  • Modification sites at PhosphoSitePlus

Other Protein References for LPCAT3 Gene

No data available for DME Specific Peptides for LPCAT3 Gene

Domains & Families for LPCAT3 Gene

Gene Families for LPCAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for LPCAT3 Gene

InterPro:
Blocks:
  • Membrane bound O-acyl transferase, MBOAT
ProtoNet:

Suggested Antigen Peptide Sequences for LPCAT3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55747, highly similar to Membrane bound O-acyltransferase domain-containing protein 5 (EC 2.3.-.-) (B7Z3N3_HUMAN)
  • cDNA FLJ59910, highly similar to Membrane bound O-acyltransferase domain-containing protein 5 (EC 2.3.-.-) (B7Z3N5_HUMAN)
  • Membrane-bound O-acyltransferase domain-containing protein 5 (MBOA5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P1A2

UniProtKB/Swiss-Prot:

MBOA5_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization.
  • Belongs to the membrane-bound acyltransferase family.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with LPCAT3: view

Function for LPCAT3 Gene

Molecular function for LPCAT3 Gene

UniProtKB/Swiss-Prot Function:
Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18782225, PubMed:18195019, PubMed:18772128). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18782225, PubMed:18195019, PubMed:18772128). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence={ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:32995, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64381, ChEBI:CHEBI:64612; EC=2.3.1.n7; Evidence={ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:33191, ChEBI:CHEBI:57262, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64379; EC=2.3.1.n6; Evidence={ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37563, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:58168, ChEBI:CHEBI:60000; Evidence={ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37559, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:58168, ChEBI:CHEBI:75063; Evidence={ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37515, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72998, ChEBI:CHEBI:75018; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35987, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72998, ChEBI:CHEBI:73000; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37511, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74966, ChEBI:CHEBI:75017; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37655, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64489, ChEBI:CHEBI:75062; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35983, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37527, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37383, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74667; Evidence={ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37207, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:72998, ChEBI:CHEBI:74000; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35995, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37483, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74966, ChEBI:CHEBI:74967; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35999, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000269|PubMed:18195019, ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37479, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:73858, ChEBI:CHEBI:74965; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37487, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74968, ChEBI:CHEBI:74970; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37387, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74669; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37391, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74670; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37395, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74671; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37579, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64381, ChEBI:CHEBI:75069; Evidence={ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37503, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74971, ChEBI:CHEBI:74977; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:64228, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:149768, ChEBI:CHEBI:149770; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37575, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64381, ChEBI:CHEBI:75067; Evidence={ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:36023, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37495, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74971, ChEBI:CHEBI:74975; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:64204, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:149768, ChEBI:CHEBI:149769; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA; Xref=Rhea:RHEA:37635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:77288, ChEBI:CHEBI:77295; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37567, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64379, ChEBI:CHEBI:75066; Evidence={ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37571, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:64379, ChEBI:CHEBI:75065; Evidence={ECO:0000269|PubMed:18782225};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37531, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37407, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74617, ChEBI:CHEBI:74905; Evidence={ECO:0000250|UniProtKB:Q91V01};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37535, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:75020, ChEBI:CHEBI:75031; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37375, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:74617, ChEBI:CHEBI:74892; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37539, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75020, ChEBI:CHEBI:75032; Evidence={ECO:0000269|PubMed:18195019};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA; Xref=Rhea:RHEA:37379, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:74617, ChEBI:CHEBI:74897; Evidence={ECO:0000269|PubMed:18772128};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41.29 uM for palmitoyl-CoA {ECO:0000269|PubMed:18195019}; KM=36.65 uM for stearoyl-CoA {ECO:0000269|PubMed:18195019}; KM=72.68 uM for oleoyl-CoA {ECO:0000269|PubMed:18195019}; KM=201.4 uM for linoleoyl-CoA {ECO:0000269|PubMed:18195019}; KM=71.56 uM for arachidonoyl-CoA {ECO:0000269|PubMed:18195019}; KM=72.19 uM for 1-palmitoyl-lysophosphatidylcholine {ECO:0000269|PubMed:18195019}; Vmax=1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269|PubMed:18195019}; Vmax=996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269|PubMed:18195019}; Vmax=4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269|PubMed:18195019}; Vmax=18148 nmol/min/mg enzyme with linoleoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269|PubMed:18195019}; Vmax=6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269|PubMed:18195019};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by thimerosal.

Enzyme Numbers (IUBMB) for LPCAT3 Gene

Phenotypes From GWAS Catalog for LPCAT3 Gene

Gene Ontology (GO) - Molecular Function for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA,IBA 21873635
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity IMP 22511767
GO:0071617 lysophospholipid acyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with LPCAT3: view
genes like me logo Genes that share phenotypes with LPCAT3: view

Animal Models for LPCAT3 Gene

MGI Knock Outs for LPCAT3:
  • Lpcat3 Lpcat3<tm1a(EUCOMM)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPCAT3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPCAT3 Gene

Localization for LPCAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT3 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPCAT3 gene
Compartment Confidence
plasma membrane 2
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPCAT3 Gene

Pathways & Interactions for LPCAT3 Gene

genes like me logo Genes that share pathways with LPCAT3: view

Pathways by source for LPCAT3 Gene

UniProtKB/Swiss-Prot Q6P1A2-MBOA5_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006656 phosphatidylcholine biosynthetic process IBA 21873635
GO:0008654 phospholipid biosynthetic process IEA --
GO:0030258 lipid modification IBA 21873635
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for SIGNOR curated interactions for LPCAT3 Gene

Drugs & Compounds for LPCAT3 Gene

(4) Drugs for LPCAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
L-Dilinoleoyllecithin Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0

(74) Additional Compounds for LPCAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • Dodecenoyl-CoA
  • Dodecenoyl+2-dodecenoyl, (e)-isomer
  • Dodecenoyl-coenzyme A
  • Dodecenoyl+2-dodecenoyl
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with LPCAT3: view

Transcripts for LPCAT3 Gene

mRNA/cDNA for LPCAT3 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPCAT3

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LPCAT3 Gene

GeneLoc Exon Structure for
LPCAT3

Expression for LPCAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPCAT3 Gene

Protein differential expression in normal tissues from HIPED for LPCAT3 Gene

This gene is overexpressed in Nasal epithelium (34.6) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LPCAT3 Gene



Protein tissue co-expression partners for LPCAT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPCAT3

SOURCE GeneReport for Unigene cluster for LPCAT3 Gene:

Hs.655248

mRNA Expression by UniProt/SwissProt for LPCAT3 Gene:

Q6P1A2-MBOA5_HUMAN
Tissue specificity: Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils.

Evidence on tissue expression from TISSUES for LPCAT3 Gene

  • Liver(2.4)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with LPCAT3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPCAT3 Gene

Orthologs for LPCAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPCAT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LPCAT3 30 31
  • 99.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LPCAT3 30 31
  • 91.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lpcat3 30
  • 87.95 (n)
Mouse
(Mus musculus)
Mammalia Lpcat3 30 17 31
  • 87.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LPCAT3 30 31
  • 87.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LPCAT3 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT3 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LPCAT3 30 31
  • 72.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LPCAT3 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lpcat3 30
  • 68.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii lpcat3 30 31
  • 63.11 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta nes 30 31
  • 50.23 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012258 30
  • 49.43 (n)
Worm
(Caenorhabditis elegans)
Secernentea mboa-6 30 31
  • 45.85 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9665 31
  • 38 (a)
OneToOne
Species where no ortholog for LPCAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LPCAT3 Gene

ENSEMBL:
Gene Tree for LPCAT3 (if available)
TreeFam:
Gene Tree for LPCAT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPCAT3: view image

Paralogs for LPCAT3 Gene

Paralogs for LPCAT3 Gene

Pseudogenes.org Pseudogenes for LPCAT3 Gene

genes like me logo Genes that share paralogs with LPCAT3: view

Variants for LPCAT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPCAT3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs200178788 Benign: not provided 6,981,910(-) A/G
NM_005768.6(LPCAT3):c.367-6T>C
INTRON
rs60718946 Benign: not provided 6,981,860(-) G/A
NM_005768.6(LPCAT3):c.411C>T (p.Tyr137=)
SYNONYMOUS
rs1984564 - p.Ile217Thr
rs34196984 - p.Phe63Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LPCAT3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LPCAT3 Gene

Variant ID Type Subtype PubMed ID
esv1188372 CNV insertion 17803354
esv2579054 CNV insertion 19546169
esv3628412 CNV loss 21293372
nsv1035811 CNV gain 25217958
nsv1039509 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv480390 CNV novel sequence insertion 20440878
nsv509453 CNV insertion 20534489
nsv513352 CNV insertion 21212237
nsv513353 CNV insertion 21212237

Variation tolerance for LPCAT3 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.28; 90.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPCAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPCAT3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT3 Gene

Disorders for LPCAT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LPCAT3 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LPCAT3

genes like me logo Genes that share disorders with LPCAT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPCAT3 Gene

Publications for LPCAT3 Gene

  1. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. (PMID: 18195019) Zhao Y … Cao G (The Journal of biological chemistry 2008) 2 3 4
  2. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 2 3 4
  3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PMID: 18772128) Gijón MA … Voelker DR (The Journal of biological chemistry 2008) 3 4
  4. Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity. (PMID: 18782225) Matsuda S … Arai H (Genes to cells : devoted to molecular & cellular mechanisms 2008) 3 4
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4

Products for LPCAT3 Gene