This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcho... See more...

Aliases for LPCAT2 Gene

Aliases for LPCAT2 Gene

  • Lysophosphatidylcholine Acyltransferase 2 2 3 4 5
  • Acetyl-CoA:Lyso-Platelet-Activating Factor Acetyltransferase 3 4
  • 1-Alkylglycerophosphocholine O-Acetyltransferase 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 11 3 4
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • Lysophosphatidic Acid Acyltransferase Alpha 3 4
  • Acetyl-CoA:Lyso-PAF Acetyltransferase 3 4
  • Lyso-PAF Acetyltransferase 3 4
  • LysoPC Acyltransferase 2 3 4
  • 1-AGP Acyltransferase 11 3 4
  • Acyltransferase-Like 1 3 4
  • LPC Acyltransferase 2 3 4
  • LPAAT-Alpha 3 4
  • EC 2.3.1.23 4 52
  • 1-AGPAT 11 3 4
  • LysoPAFAT 3 4
  • AGPAT11 3 4
  • LPCAT-2 3 4
  • AYTL1 3 4
  • Lyso-Platelet-Activating Factor (PAF) Acetyltransferase 3
  • Acyl-CoA:Lysophosphatidylcholine Acyltransferase 2 3
  • Acyltransferase Like 1 2
  • EC 2.3.1.51 4
  • EC 2.3.1.67 4
  • EC 2.3.1 52

External Ids for LPCAT2 Gene

Previous HGNC Symbols for LPCAT2 Gene

  • AYTL1

Previous GeneCards Identifiers for LPCAT2 Gene

  • GC16P054102
  • GC16P055542
  • GC16P041430

Summaries for LPCAT2 Gene

Entrez Gene Summary for LPCAT2 Gene

  • This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

GeneCards Summary for LPCAT2 Gene

LPCAT2 (Lysophosphatidylcholine Acyltransferase 2) is a Protein Coding gene. Diseases associated with LPCAT2 include Multicentric Osteolysis, Nodulosis, And Arthropathy and Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LPCAT1.

UniProtKB/Swiss-Prot Summary for LPCAT2 Gene

  • Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.

Additional gene information for LPCAT2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPCAT2 Gene

Genomics for LPCAT2 Gene

GeneHancer (GH) Regulatory Elements for LPCAT2 Gene

Promoters and enhancers for LPCAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J055508 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 512.4 +0.7 700 3.4 NRF1 POLR2G PHF8 ZIC2 POLR2A ZBTB10 ZBTB26 HDAC2 MXI1 ZNF341 LPCAT2 NONHSAG019512.2 MMP2 ENSG00000261997
GH16J055565 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 519.4 +57.5 57500 8.6 NCOR1 ZNF316 MAFF MYNN TRIM24 FOS MAFK SPI1 FOSL1 EZH2 LPCAT2 CAPNS2 ENSG00000261997 RF00994-384
GH16J055535 Enhancer 0.8 Ensembl ENCODE 21.3 +29.5 29500 9.8 JUND FOS CTCF FOXA2 MAFF FOSL2 MAFK PBX2 SPI1 FOSL1 ENSG00000261997 LPCAT2 CAPNS2 MMP2 SLC6A2 RF00994-384 NONHSAG019512.2
GH16J055552 Enhancer 0.7 Ensembl ENCODE 19.8 +43.8 43799 1.2 ZNF316 MAFF FOS MAFK PBX2 NFE2 EZH2 JUND MAFG MEIS2 RF00994-384 LPCAT2 MMP2 ENSG00000261997
GH16J055558 Enhancer 0.7 Ensembl ENCODE 18.2 +50.0 50000 4 GATA3 PBX2 SPI1 JUND RCOR1 MEIS2 ZNF48 CHD2 POLR2A GATA2 LPCAT2 MMP2 ENSG00000261997 CAPNS2 RF00994-384
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPCAT2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPCAT2

Top Transcription factor binding sites by QIAGEN in the LPCAT2 gene promoter:
  • AML1a
  • ATF6
  • CREB
  • E47
  • GR
  • GR-alpha
  • Hand1
  • Nkx6-1
  • STAT1

Genomic Locations for LPCAT2 Gene

Genomic Locations for LPCAT2 Gene
chr16:55,509,001-55,586,670
(GRCh38/hg38)
Size:
77,670 bases
Orientation:
Plus strand
chr16:55,542,910-55,620,582
(GRCh37/hg19)
Size:
77,673 bases
Orientation:
Plus strand

Genomic View for LPCAT2 Gene

Genes around LPCAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT2 Gene

Proteins for LPCAT2 Gene

  • Protein details for LPCAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5N7-PCAT2_HUMAN
    Recommended name:
    Lysophosphatidylcholine acyltransferase 2
    Protein Accession:
    Q7L5N7
    Secondary Accessions:
    • A3KBM1
    • Q6MZJ6
    • Q9NX23

    Protein attributes for LPCAT2 Gene

    Size:
    544 amino acids
    Molecular mass:
    60208 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91199.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAE46034.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for LPCAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPCAT2 Gene

Selected DME Specific Peptides for LPCAT2 Gene

Q7L5N7:
  • APHSTFFD
  • GVPVQPVL

Post-translational modifications for LPCAT2 Gene

  • Ubiquitination at Lys386 and Lys389
  • Modification sites at PhosphoSitePlus

Other Protein References for LPCAT2 Gene

Antibody Products

  • Boster Bio Antibodies for LPCAT2
  • Santa Cruz Biotechnology (SCBT) Antibodies for LPCAT2

Domains & Families for LPCAT2 Gene

Gene Families for LPCAT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LPCAT2 Gene

Blocks:
  • Phospholipid/glycerol acyltransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LPCAT2 Gene

GenScript: Design optimal peptide antigens:
  • Acyltransferase-like 1 (PCAT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L5N7

UniProtKB/Swiss-Prot:

PCAT2_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPCAT2: view

Function for LPCAT2 Gene

Molecular function for LPCAT2 Gene

UniProtKB/Swiss-Prot Function:
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:18461, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.67; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged (By similarity).

Enzyme Numbers (IUBMB) for LPCAT2 Gene

Phenotypes From GWAS Catalog for LPCAT2 Gene

Gene Ontology (GO) - Molecular Function for LPCAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LPCAT2: view
genes like me logo Genes that share phenotypes with LPCAT2: view

Animal Model Products

CRISPR Products

miRNA for LPCAT2 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPCAT2 Gene

Localization for LPCAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT2 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPCAT2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
plasma membrane 3
mitochondrion 3
extracellular 2
cytosol 2
peroxisome 1
nucleus 1
endosome 1
lysosome 1
cytoskeleton 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Lipid droplets (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPCAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack ISS,IEA --
genes like me logo Genes that share ontologies with LPCAT2: view

Pathways & Interactions for LPCAT2 Gene

genes like me logo Genes that share pathways with LPCAT2: view

UniProtKB/Swiss-Prot Q7L5N7-PCAT2_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for LPCAT2 Gene

;

Gene Ontology (GO) - Biological Process for LPCAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006663 platelet activating factor biosynthetic process ISS,IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036151 phosphatidylcholine acyl-chain remodeling IDA,TAS --
genes like me logo Genes that share ontologies with LPCAT2: view

No data available for SIGNOR curated interactions for LPCAT2 Gene

Drugs & Compounds for LPCAT2 Gene

(1) Drugs for LPCAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(51) Additional Compounds for LPCAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
LysoPA(0:0/16:0)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic Acid(0:0/18:0)
  • Lysophosphatidic Acid(18:0)
  • 2-stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic Acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic Acid(0:0/18:1)
  • 2-oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic Acid(18:2)
genes like me logo Genes that share compounds with LPCAT2: view

Transcripts for LPCAT2 Gene

mRNA/cDNA for LPCAT2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT2 Gene

No ASD Table

Relevant External Links for LPCAT2 Gene

GeneLoc Exon Structure for
LPCAT2

Expression for LPCAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPCAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPCAT2 Gene

This gene is overexpressed in Whole Blood (x7.5) and Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for LPCAT2 Gene

This gene is overexpressed in Breast (43.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LPCAT2 Gene



Protein tissue co-expression partners for LPCAT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPCAT2

SOURCE GeneReport for Unigene cluster for LPCAT2 Gene:

Hs.460857

Evidence on tissue expression from TISSUES for LPCAT2 Gene

  • Kidney(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with LPCAT2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPCAT2 Gene

Orthologs for LPCAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LPCAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPCAT2 31 30
  • 99.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LPCAT2 31 30
  • 90.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LPCAT2 31 30
  • 89.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lpcat2 17 31 30
  • 84.62 (n)
rat
(Rattus norvegicus)
Mammalia Lpcat2 30
  • 83.39 (n)
oppossum
(Monodelphis domestica)
Mammalia LPCAT2 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT2 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPCAT2 31 30
  • 69.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPCAT2 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat2 30
  • 65.64 (n)
zebrafish
(Danio rerio)
Actinopterygii lpcat2 31 30
  • 62.27 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000596 30
  • 47.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32699 31
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45670 30
  • 44.78 (n)
rice
(Oryza sativa)
Liliopsida Os06g0712300 30
  • 44.28 (n)
Species where no ortholog for LPCAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPCAT2 Gene

ENSEMBL:
Gene Tree for LPCAT2 (if available)
TreeFam:
Gene Tree for LPCAT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPCAT2: view image

Paralogs for LPCAT2 Gene

Paralogs for LPCAT2 Gene

(3) SIMAP similar genes for LPCAT2 Gene using alignment to 2 proteins:

  • PCAT2_HUMAN
  • H3BU68_HUMAN

Pseudogenes.org Pseudogenes for LPCAT2 Gene

genes like me logo Genes that share paralogs with LPCAT2: view

Variants for LPCAT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPCAT2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
768779 Benign: not provided 55,525,601(+) G/A MISSENSE_VARIANT
773582 Benign: not provided 55,528,447(+) G/A MISSENSE_VARIANT
773583 Benign: not provided 55,579,140(+) C/T MISSENSE_VARIANT
rs1567390809 Pathogenic: Multicentric osteolysis, nodulosis and arthropathy 55,519,320(+) G/A INTRON_VARIANT
rs837550 - p.Met163Ile

Additional dbSNP identifiers (rs#s) for LPCAT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LPCAT2 Gene

Variant ID Type Subtype PubMed ID
dgv2982n100 CNV loss 25217958
dgv2983n100 CNV loss 25217958
dgv2984n100 CNV loss 25217958
esv3360446 CNV insertion 20981092
nsv1062908 CNV loss 25217958
nsv521337 CNV loss 19592680

Variation tolerance for LPCAT2 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPCAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPCAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT2 Gene

Disorders for LPCAT2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LPCAT2 Gene - From: ClinVar and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LPCAT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LPCAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPCAT2 Gene

Publications for LPCAT2 Gene

  1. Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. (PMID: 20363836) Agarwal AK … Garg A (Journal of lipid research 2010) 2 3 4 54
  2. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. (PMID: 17182612) Shindou H … Shimizu T (The Journal of biological chemistry 2007) 2 3 4 54
  3. Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. (PMID: 21498505) Moessinger C … Thiele C (The Journal of biological chemistry 2011) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54

Products for LPCAT2 Gene

  • Signalway ELISA kits for LPCAT2
  • Signalway Proteins for LPCAT2

Sources for LPCAT2 Gene