This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated ... See more...

Aliases for LPCAT1 Gene

Aliases for LPCAT1 Gene

  • Lysophosphatidylcholine Acyltransferase 1 2 3 4 5
  • Acetyl-CoA:Lyso-Platelet-Activating Factor Acetyltransferase 3 4
  • 1-Alkylglycerophosphocholine O-Acetyltransferase 3 4
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • Phosphonoformate Immuno-Associated Protein 3 3 4
  • Acetyl-CoA:Lyso-PAF Acetyltransferase 3 4
  • Lyso-PAF Acetyltransferase 3 4
  • LysoPC Acyltransferase 1 3 4
  • Acyltransferase-Like 2 3 4
  • LPC Acyltransferase 1 3 4
  • LysoPAFAT 3 4
  • AGPAT10 2 3
  • LPCAT-1 3 4
  • AGPAT9 2 3
  • PFAAP3 3 4
  • AYTL2 3 4
  • 1-Alkenylglycerophosphocholine O-Acyltransferase 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 4
  • Acyltransferase Like 2 2
  • EC 2.3.1.23 4
  • EC 2.3.1.51 4
  • EC 2.3.1.25 4
  • EC 2.3.1.67 4
  • FLJ12443 2
  • LPCAT1 5
  • Lpcat 3

External Ids for LPCAT1 Gene

Previous HGNC Symbols for LPCAT1 Gene

  • AYTL2

Previous GeneCards Identifiers for LPCAT1 Gene

  • GC05M001516

Summaries for LPCAT1 Gene

Entrez Gene Summary for LPCAT1 Gene

  • This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]

GeneCards Summary for LPCAT1 Gene

LPCAT1 (Lysophosphatidylcholine Acyltransferase 1) is a Protein Coding gene. Diseases associated with LPCAT1 include Pulmonary Alveolar Microlithiasis and Pediatric Hepatocellular Carcinoma. Among its related pathways are Acyl chain remodelling of PE and Synthesis of PC. Gene Ontology (GO) annotations related to this gene include calcium ion binding and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is LPCAT2.

UniProtKB/Swiss-Prot Summary for LPCAT1 Gene

  • Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPCAT1 Gene

Genomics for LPCAT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LPCAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPCAT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPCAT1

Top Transcription factor binding sites by QIAGEN in the LPCAT1 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AP-4
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • POU2F1
  • POU2F1a

Genomic Locations for LPCAT1 Gene

Genomic Locations for LPCAT1 Gene
chr5:1,456,480-1,523,962
(GRCh38/hg38)
Size:
67,483 bases
Orientation:
Minus strand
chr5:1,456,595-1,524,092
(GRCh37/hg19)
Size:
67,498 bases
Orientation:
Minus strand

Genomic View for LPCAT1 Gene

Genes around LPCAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT1 Gene

Proteins for LPCAT1 Gene

  • Protein details for LPCAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NF37-PCAT1_HUMAN
    Recommended name:
    Lysophosphatidylcholine acyltransferase 1
    Protein Accession:
    Q8NF37
    Secondary Accessions:
    • Q1HAQ1
    • Q7Z4G6
    • Q8N3U7
    • Q8WUL8
    • Q9GZW6

    Protein attributes for LPCAT1 Gene

    Size:
    534 amino acids
    Molecular mass:
    59151 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14061.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14065.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for LPCAT1 Gene

Post-translational modifications for LPCAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LPCAT1 Gene

No data available for DME Specific Peptides for LPCAT1 Gene

Domains & Families for LPCAT1 Gene

Protein Domains for LPCAT1 Gene

InterPro:
Blocks:
  • Phospholipid/glycerol acyltransferase
ProtoNet:

Suggested Antigen Peptide Sequences for LPCAT1 Gene

GenScript: Design optimal peptide antigens:
  • Acyltransferase like 2, isoform CRA_a (D3DTC2_HUMAN)
  • Phosphonoformate immuno-associated protein 3 (PCAT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NF37

UniProtKB/Swiss-Prot:

PCAT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
  • The di-lysine motif may confer endoplasmic reticulum localization.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPCAT1: view

Function for LPCAT1 Gene

Molecular function for LPCAT1 Gene

UniProtKB/Swiss-Prot Function:
Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:12937, ChEBI:CHEBI:57287, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168, ChEBI:CHEBI:58342; EC=2.3.1.23; Evidence={ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:21498505};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, ChEBI:CHEBI:58608; EC=2.3.1.51; Evidence={ECO:0000250|UniProtKB:Q1HAQ0};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:18461, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.67; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:10344, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:77286, ChEBI:CHEBI:77287; EC=2.3.1.25; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence={ECO:0000250|UniProtKB:Q1HAQ0};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35991, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000269|PubMed:21498505};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35983, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64496, ChEBI:CHEBI:72744; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37819, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:77287, ChEBI:CHEBI:77304; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35851, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37511, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74966, ChEBI:CHEBI:75017; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37655, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64489, ChEBI:CHEBI:75062; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37839, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75216, ChEBI:CHEBI:75290; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37527, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73858, ChEBI:CHEBI:75026; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37383, ChEBI:CHEBI:28610, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74667; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37843, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74968, ChEBI:CHEBI:75294; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37855, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:72998, ChEBI:CHEBI:75301; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37859, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:72998, ChEBI:CHEBI:75302; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37863, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430, ChEBI:CHEBI:72998, ChEBI:CHEBI:75300; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37515, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:72998, ChEBI:CHEBI:75018; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37867, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:72998, ChEBI:CHEBI:75304; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:35995, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72998, ChEBI:CHEBI:73002; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37475, ChEBI:CHEBI:57287, ChEBI:CHEBI:72998, ChEBI:CHEBI:74298, ChEBI:CHEBI:74963; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37703, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:72998, ChEBI:CHEBI:75219; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:43264, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:72998, ChEBI:CHEBI:82943; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37719, ChEBI:CHEBI:44811, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64496; Evidence={ECO:0000250|UniProtKB:Q3TFD2};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA; Xref=Rhea:RHEA:37803, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:58168, ChEBI:CHEBI:75279; Evidence={ECO:0000250|UniProtKB:Q1HAQ0};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:33315, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57970, ChEBI:CHEBI:64862; Evidence={ECO:0000250|UniProtKB:Q1HAQ0};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:64840, ChEBI:CHEBI:75280; Evidence={ECO:0000250|UniProtKB:Q1HAQ0};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.6 uM for palmitoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=4 uM for oleoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=7.8 uM for linoleoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=4.3 uM for arachidonyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=6.8 uM for 1-palmitoyl-LPC (in the presence of palmitoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=27 uM for 1-palmitoyl-LPC (in the presence of oleoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=44.5 uM for 1-palmitoyl-LPC (in the presence of linoleoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18156367}; KM=9.2 uM for 1-palmitoyl-LPC (in the presence of arachidonyl-CoA as cosubstrate) {ECO:0000269|PubMed:18156367}; Vmax=2.8 nmol/min/mg enzyme towards palmitoyl-CoA using 1-palmitoyl-LPC as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=5.6 nmol/min/mg enzyme towards oleoyl-CoA using 1-palmitoyl-LPC as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=11.3 nmol/min/mg enzyme towards linoleoyl-CoA using 1-palmitoyl-LPC as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=4.6 nmol/min/mg enzyme towards arachidonyl-CoA using 1-palmitoyl-LPC as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=1.4 nmol/min/mg enzyme towards 1-palmitoyl-LPC using palmitoyl-CoA as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=6.8 nmol/min/mg enzyme towards 1-palmitoyl-LPC using oleoyl-CoA as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=11.8 nmol/min/mg enzyme towards 1-palmitoyl-LPC using linoleoyl-CoA as cosubstrate {ECO:0000269|PubMed:18156367}; Vmax=3.6 nmol/min/mg enzyme with towards 1-palmitoyl-LPC using arachidonyl-CoA as cosubstrate {ECO:0000269|PubMed:18156367}; pH dependence: Optimum pH is 5.5 and 7.5. {ECO:0000269|PubMed:18156367};

Enzyme Numbers (IUBMB) for LPCAT1 Gene

Phenotypes From GWAS Catalog for LPCAT1 Gene

Gene Ontology (GO) - Molecular Function for LPCAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LPCAT1: view
genes like me logo Genes that share phenotypes with LPCAT1: view

Animal Models for LPCAT1 Gene

MGI Knock Outs for LPCAT1:
  • Lpcat1 Lpcat1<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPCAT1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPCAT1 Gene

Localization for LPCAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT1 Gene

Endoplasmic reticulum membrane. Single-pass type II membrane protein. Golgi apparatus membrane. Single-pass type II membrane protein. Cell membrane. Single-pass type II membrane protein. Lipid droplet. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000269 PubMed:21498505}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPCAT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
lysosome 4
golgi apparatus 4
mitochondrion 3
nucleus 3
cytosol 3
extracellular 2
peroxisome 2
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Lipid droplets (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPCAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus ISS --
GO:0005811 lipid droplet IEA,IDA 21498505
genes like me logo Genes that share ontologies with LPCAT1: view

Pathways & Interactions for LPCAT1 Gene

genes like me logo Genes that share pathways with LPCAT1: view

UniProtKB/Swiss-Prot Q8NF37-PCAT1_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for LPCAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0008654 phospholipid biosynthetic process ISS --
genes like me logo Genes that share ontologies with LPCAT1: view

No data available for SIGNOR curated interactions for LPCAT1 Gene

Drugs & Compounds for LPCAT1 Gene

(4) Drugs for LPCAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0
Calcium Nutra 6556

(80) Additional Compounds for LPCAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with LPCAT1: view

Transcripts for LPCAT1 Gene

mRNA/cDNA for LPCAT1 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPCAT1

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT1 Gene

No ASD Table

Relevant External Links for LPCAT1 Gene

GeneLoc Exon Structure for
LPCAT1

Expression for LPCAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPCAT1 Gene

mRNA differential expression in normal tissues according to GTEx for LPCAT1 Gene

This gene is overexpressed in Whole Blood (x6.2) and Lung (x5.2).

Protein differential expression in normal tissues from HIPED for LPCAT1 Gene

This gene is overexpressed in Fetal Brain (9.8), Lung (8.6), NK cells (8.1), Peripheral blood mononuclear cells (7.2), and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LPCAT1 Gene



Protein tissue co-expression partners for LPCAT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPCAT1

SOURCE GeneReport for Unigene cluster for LPCAT1 Gene:

Hs.368853

mRNA Expression by UniProt/SwissProt for LPCAT1 Gene:

Q8NF37-PCAT1_HUMAN
Tissue specificity: Erythrocytes.

Evidence on tissue expression from TISSUES for LPCAT1 Gene

  • Nervous system(4.8)
  • Spleen(4.5)
  • Eye(4.4)
  • Lung(3.4)
  • Kidney(2.7)
  • Heart(2.5)
  • Intestine(2.4)
  • Lymph node(2.2)
  • Blood(2.2)
  • Liver(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with LPCAT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPCAT1 Gene

Orthologs for LPCAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LPCAT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LPCAT1 30 31
  • 99.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lpcat1 30
  • 82.96 (n)
Cow
(Bos Taurus)
Mammalia LPCAT1 30 31
  • 82.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lpcat1 30 17 31
  • 82.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LPCAT1 30 31
  • 82.13 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT1 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LPCAT1 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LPCAT1 30 31
  • 69.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LPCAT1 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lpcat1 30
  • 69.08 (n)
Str.3303 30
Zebrafish
(Danio rerio)
Actinopterygii lpcat1 30 31
  • 66.87 (n)
OneToMany
CABZ01078889.1 31
  • 50 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG32699 30 31
  • 49.75 (n)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7337 30
Species where no ortholog for LPCAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LPCAT1 Gene

ENSEMBL:
Gene Tree for LPCAT1 (if available)
TreeFam:
Gene Tree for LPCAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPCAT1: view image

Paralogs for LPCAT1 Gene

Paralogs for LPCAT1 Gene

(3) SIMAP similar genes for LPCAT1 Gene using alignment to 1 proteins:

  • PCAT1_HUMAN
genes like me logo Genes that share paralogs with LPCAT1: view

Variants for LPCAT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPCAT1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
716860 Benign: not provided 1,470,826(-) C/T SYNONYMOUS_VARIANT
723828 Benign: not provided 1,470,865(-) C/T SYNONYMOUS_VARIANT
rs587776361 Uncertain Significance: not provided 1,470,869(-) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LPCAT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LPCAT1 Gene

Variant ID Type Subtype PubMed ID
dgv3022n106 CNV deletion 24896259
dgv3198e59 CNV duplication 20981092
dgv9536n54 CNV loss 21841781
dgv9541n54 CNV gain 21841781
esv2387011 CNV deletion 18987734
esv2462178 CNV deletion 19546169
esv27188 CNV loss 19812545
esv2729492 CNV deletion 23290073
esv2729493 CNV deletion 23290073
esv2729494 CNV deletion 23290073
esv2729495 CNV deletion 23290073
esv3186 CNV loss 18987735
esv3359326 CNV insertion 20981092
esv3395355 CNV duplication 20981092
esv3444246 CNV insertion 20981092
esv3565360 CNV deletion 23714750
esv3565361 CNV deletion 23714750
esv8815 CNV loss 19470904
esv994195 CNV insertion 20482838
nsv1073418 CNV deletion 25765185
nsv1073419 CNV deletion 25765185
nsv1112865 CNV deletion 24896259
nsv1114640 CNV deletion 24896259
nsv1117981 CNV deletion 24896259
nsv1133013 OTHER inversion 24896259
nsv1139363 CNV deletion 24896259
nsv1139364 CNV deletion 24896259
nsv1147234 OTHER inversion 26484159
nsv1149954 CNV deletion 26484159
nsv329642 CNV deletion 16902084
nsv461910 CNV loss 19166990
nsv596629 CNV gain 21841781
nsv596877 CNV loss 21841781
nsv596878 CNV loss 21841781
nsv596879 CNV gain 21841781
nsv596881 CNV gain+loss 21841781
nsv596882 CNV gain 21841781
nsv830187 CNV loss 17160897
nsv950629 CNV deletion 24416366

Variation tolerance for LPCAT1 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPCAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPCAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT1 Gene

Disorders for LPCAT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LPCAT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pulmonary alveolar microlithiasis
  • pulam
pediatric hepatocellular carcinoma
  • childhood hepatocellular carcinoma
newborn respiratory distress syndrome
  • hmd - hyaline membrane disease
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LPCAT1

genes like me logo Genes that share disorders with LPCAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPCAT1 Gene

Publications for LPCAT1 Gene

  1. Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. (PMID: 16704971) Nakanishi H … Shimizu T (The Journal of biological chemistry 2006) 2 3 4
  2. Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. (PMID: 21498505) Moessinger C … Thiele C (The Journal of biological chemistry 2011) 3 4
  3. Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes. (PMID: 18156367) Soupene E … Kuypers FA (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4
  4. Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. (PMID: 18285344) Harayama T … Shimizu T (The Journal of biological chemistry 2008) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for LPCAT1 Gene

  • Signalway ELISA kits for LPCAT1

Sources for LPCAT1 Gene