Aliases for LPAR6 Gene
Aliases for LPAR6 Gene
External Ids for LPAR6 Gene
- HGNC: 15520
- Entrez Gene: 10161
- Ensembl: ENSG00000139679
- OMIM: 609239
- UniProtKB: P43657
Previous HGNC Symbols for LPAR6 Gene
- P2RY5
Previous GeneCards Identifiers for LPAR6 Gene
- GC13M047885
- GC13M048963
- GC13M029777
Summaries for LPAR6 Gene
-
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
GeneCards Summary for LPAR6 Gene
LPAR6 (Lysophosphatidic Acid Receptor 6) is a Protein Coding gene. Diseases associated with LPAR6 include Hypotrichosis 8 and Woolly Hair Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is LPAR4.
UniProtKB/Swiss-Prot for LPAR6 Gene
-
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
Additional gene information for LPAR6 Gene
- Monarch Initiative
- Search for LPAR6 at DataMed
- Search for LPAR6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR6 Gene
Genomics for LPAR6 Gene
GeneHancer (GH) Regulatory Elements for LPAR6 Gene
Promoters and enhancers for LPAR6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around LPAR6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for LPAR6 Gene
Genomic Locations for LPAR6 Gene
- chr13:48,389,567-48,444,704
- (GRCh38/hg38)
- Size:
- 55,138 bases
- Orientation:
- Minus strand
- chr13:48,963,707-49,018,840
- (GRCh37/hg19)
- Size:
- 55,134 bases
- Orientation:
- Minus strand
Genomic View for LPAR6 Gene
Genes around LPAR6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q14.2 by Entrez Gene
- 13q14.2 by HGNC
- 13q14.2 by Ensembl
LPAR6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LPAR6 Gene
Proteins for LPAR6 Gene
-
Protein details for LPAR6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43657-LPAR6_HUMAN
- Recommended name:
- Lysophosphatidic acid receptor 6
- Protein Accession:
- P43657
- A4FTW9
- B3KVF2
- F2YGU4
- O15133
- Q3KPF5
- Q53FA0
- Q5VW44
- Q7Z3S0
- Q7Z3S6
Protein attributes for LPAR6 Gene
- Size:
- 344 amino acids
- Molecular mass:
- 39392 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- This is a nested gene within intron 17 of the retinoblastoma gene.
- SequenceCaution:
-
- Sequence=L11910; Type=Frameshift; Positions=31; Evidence={ECO:0000305};
Protein Expression for LPAR6 Gene
Post-translational modifications for LPAR6 Gene
Other Protein References for LPAR6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LPAR6
- Novus Biologicals Antibodies for LPAR6
-
Abcam antibodies for LPAR6
- Invitrogen Antibodies for LPAR6
- GeneTex LPAR6 Antibody for LPAR6
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LPAR6
- Origene Custom Protein Services for LPAR6
- Novus Biologicals proteins for LPAR6
- antibodies-online: Search results for 3 available LPAR6 Proteins ranked by validation data
- Compare Top LPAR6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for LPAR6
Assay Products
No data available for DME Specific Peptides for LPAR6 Gene
Domains & Families for LPAR6 Gene
Gene Families for LPAR6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- G-protein coupled receptors
- Potential drug targets
- Predicted membrane proteins
Protein Domains for LPAR6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LPAR6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P43657- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for LPAR6 Gene
Molecular function for LPAR6 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IBA,IEA | -- |
| GO:0070915 | lysophosphatidic acid receptor activity | IBA | -- |
Phenotypes for LPAR6 Gene
- MGI mutant phenotypes for LPAR6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LPAR6:
Animal Models for LPAR6 Gene
- MGI Knock Outs for LPAR6:
-
- Lpar6 Lpar6<tm1.1(KOMP)Vlcg>
Animal Model Products
-
Taconic Biosciences Mouse Models for LPAR6
- Cyagen custom Knockout/knockin (KOKI) mouse models for LPAR6
-
CRISPR Products
-
OriGene CRISPR knockouts for LPAR6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR6
- genomics-online: gRNA clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- Applied Biological Materials CRISPR for LPAR6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPAR6
- GenScript: Design CRISPR guide RNA sequences for LPAR6
miRNA for LPAR6 Gene
- miRTarBase miRNAs that target LPAR6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR6
- Browse OriGene Inhibitory RNA Products For LPAR6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR6
- genomics-online: shRNA clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LPAR6
- VectorBuilder custom plasmid, inducible vectors for LPAR6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LPAR6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LPAR6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR6
- Applied Biological Materials Clones for LPAR6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for LPAR6 (LPAR6/P2RY5)
Cell Line Products
-
Horizon Cell Lines for LPAR6
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for LPAR6 Gene
Localization for LPAR6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LPAR6 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
- Plasma membrane (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for LPAR6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Nucleotide-like (purinergic) receptors |
.01
.01
|
|
| 4 | RET signaling | ||
| 5 | Pathways in cancer | ||
Pathways by source for LPAR6 Gene
2 BioSystems pathways for LPAR6 Gene
4 KEGG pathways for LPAR6 Gene
Interacting Proteins for LPAR6 Gene
GPS-Prot Interaction Network for LPAR6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0035025 | positive regulation of Rho protein signal transduction | IBA | -- |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | IBA | -- |
No data available for SIGNOR curated interactions for LPAR6 Gene
Drugs & Compounds for LPAR6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 | |||
| MC-1 | Investigational | Pharma | 0 | |||
| 1-Oleoyl lysophosphatidic acid sodium salt | Pharma | Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 | 0 | |||
| H2L 5765834 | Pharma | LPA1,3,5 antagonist | 0 | |||
| H2L5186303 | Pharma | Potent and selective LPA2 receptor antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| LysoPA(0:0/16:0) |
|
|
||||
| LysoPA(0:0/18:0) |
|
|
||||
| LysoPA(0:0/18:1(9Z)) |
|
|
||||
| LysoPA(0:0/18:2(9Z,12Z)) |
|
|
||||
| LysoPA(16:0/0:0) |
|
|
(10) Tocris Compounds for LPAR6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of LPA1 and LPA2 | 325465-93-8 |
| 2-Methylthioadenosine diphosphate trisodium salt | Potent agonist for P2Y1, P2Y12 and P2Y13 | 475193-31-8 |
| GRI 977143 | Selective LPA2 receptor non-lipid agonist | 325850-81-5 |
| H2L 5765834 | LPA1,3,5 antagonist | 420841-84-5 |
| H2L5186303 | Potent and selective LPA2 receptor antagonist | 139262-76-3 |
| MRS 2365 | Highly potent and selective P2Y1 agonist | 436847-09-5 |
| MRS 2690 | Potent P2Y14 agonist | 15039-58-4 |
| MRS 2693 trisodium salt | Selective P2Y6 agonist | 1448858-83-0 |
| PSB 0474 | Potent and selective P2Y6 agonist | 917567-60-3 |
| TC LPA5 4 | LPA5 receptor antagonist | 1393814-38-4 |
Drug Products
Transcripts for LPAR6 Gene
mRNA/cDNA for LPAR6 Gene
- (6) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (139) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000465365 1651 bps (uc001vcc.2)
- ENST00000464486 374 bps (uc058wyi.1)
- ENST00000481832 479 bps (uc058wyj.1)
- ENST00000462781 356 bps (uc058wyk.1)
- ENST00000470937 442 bps (uc058wyl.1)
Unigene Clusters for LPAR6 Gene
- Lysophosphatidic acid receptor 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LPAR6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR6
- genomics-online: gRNA clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- Applied Biological Materials CRISPR for LPAR6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPAR6
- GenScript: Design CRISPR guide RNA sequences for LPAR6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR6
- Browse OriGene Inhibitory RNA Products For LPAR6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR6
- genomics-online: shRNA clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LPAR6
- VectorBuilder custom plasmid, inducible vectors for LPAR6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LPAR6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LPAR6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR6
- Applied Biological Materials Clones for LPAR6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for LPAR6 (LPAR6/P2RY5)
Expression for LPAR6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
-
Placenta (Extraembryonic Tissues)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAR6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LPAR6 Gene:
LPAR6SOURCE GeneReport for Unigene cluster for LPAR6 Gene:
Hs.123464mRNA Expression by UniProt/SwissProt for LPAR6 Gene:
P43657-LPAR6_HUMAN
Tissue specificity:
Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henles and Huxleys layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for LPAR6 Gene
- Blood(4.2)
- Heart(4.2)
- Nervous system(4.2)
- Skin(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR6 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
Regions:
Head and neck:
- eye
- eyelid
- face
- forehead
- head
Limb:
- arm
- upper limb
General:
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for LPAR6
-
OriGene qPCR primer pairs for LPAR6
- genomics-online: primer clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for LPAR6 Gene
Orthologs for LPAR6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LPAR6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LPAR6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | P2RY5 34 |
|
OneToOne | |
| LPAR6 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | LPAR6 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Lpar6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Lpar6 33 |
|
||
| chicken (Gallus gallus) |
Aves | LPAR6 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | LPAR6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lpar6 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lpar6a 34 33 |
|
OneToMany | |
| lpar6b 34 |
|
OneToMany |
- Species where no ortholog for LPAR6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for LPAR6 Gene
- ENSEMBL:
- Gene Tree for LPAR6 (if available)
- TreeFam:
- Gene Tree for LPAR6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LPAR6: view image
Paralogs for LPAR6 Gene
Paralogs for LPAR6 Gene
(55) SIMAP similar genes for LPAR6 Gene using alignment to 1 proteins:
- LPAR6_HUMAN
- LPAR4
- CYSLTR1
- LPAR5
- KPG_010
- CCR5
- P2RY10
- GPR174
- CCR4
- AGTR2
- F2R
- AGTR1
- CCR2
- P2RY4
- P2RY2
- IL8RB
- CXCR2
- GPR17
- CXCR1
- SSTR4
- P2RY8
- P2RY1
- KPG_011
- GPR183
- CYSLTR2
- F2RL2
- CX3CR1
- XCR1
- PTAFR
- HCAR3
- CCR8
- CCR1
- P2RY12
- SSTR2
- OXGR1
- OPRK1
- HCAR2
- GPR68
- GPR65
- GPR18
- GPR35
- CCR6
- CCR3
- OPRL1
- GPR34
- P2RY14
- CXCR4
- CCR9
- CCBP2
- ACKR3
- SSTR1
- OPRM1
- GPR55
- P2RY6
- GPR4
- GPR171
Variants for LPAR6 Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115596308 | pathogenic, Hypotrichosis 8 | 48,411,837(-) | G/A/C/T | coding_sequence_variant, missense_variant | |
| rs121434306 | pathogenic, Hypotrichosis 8 | 48,411,961(-) | G/A | coding_sequence_variant, stop_gained | |
| rs121434307 | pathogenic, Autosomal recessive woolly hair 1, with or without hypotrichosis, Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150] | 48,411,862(-) | T/A/C | coding_sequence_variant, missense_variant | |
| rs121434308 | conflicting-interpretations-of-pathogenicity, Hypotrichosis 8 | 48,411,988(-) | C/T | coding_sequence_variant, missense_variant | |
| rs121434309 | pathogenic, Hypotrichosis 8, Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150] | 48,411,859(-) | C/T | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1649n100 | CNV | gain | 25217958 |
| esv1206120 | CNV | deletion | 17803354 |
| esv1248194 | CNV | deletion | 17803354 |
| esv2747378 | CNV | deletion | 23290073 |
| esv2747379 | CNV | deletion | 23290073 |
| esv2747380 | CNV | deletion | 23290073 |
| esv29390 | CNV | gain | 19812545 |
| nsv1050786 | CNV | gain | 25217958 |
| nsv1122816 | CNV | deletion | 24896259 |
| nsv832602 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LPAR6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR6 Gene
Disorders for LPAR6 Gene
(8) MalaCards diseases for LPAR6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypotrichosis 8 |
|
|
| woolly hair syndrome |
|
|
| hypotrichosis simplex |
|
|
| hypotrichosis |
|
|
| hypotrichosis 6 |
|
|
Search LPAR6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LPAR6_HUMAN- Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis. {ECO:0000269 PubMed:18297072}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. {ECO:0000269 PubMed:18297070}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LPAR6
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for LPAR6 Gene
Publications for LPAR6 Gene
- Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K … Ogilvie A (Biochimica et biophysica acta 2000) 2 3 4 58
- Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. (PMID: 19386608) Yanagida K … Ishii S (The Journal of biological chemistry 2009) 2 3 58
- Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. (PMID: 18803659) Shimomura Y … Christiano AM (Experimental dermatology 2009) 3 22 58
- G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. (PMID: 18297070) Pasternack SM … Betz RC (Nature genetics 2008) 3 4 58
- Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. (PMID: 18297072) Shimomura Y … Christiano AM (Nature genetics 2008) 3 4 58
Products for LPAR6 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for LPAR6 (LPAR6/P2RY5)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for LPAR6
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LPAR6
- Origene Custom Protein Services for LPAR6
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR6
- Browse OriGene Inhibitory RNA Products For LPAR6
- OriGene qPCR primer pairs and template standards for LPAR6
- OriGene qPCR primer pairs for LPAR6
- OriGene CRISPR knockouts for LPAR6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LPAR6
- GenScript: Next-day shipping of latest version cDNA ORF clones for LPAR6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for LPAR6
- GenScript Custom Assay Services for LPAR6
- GenScript Custom overexpressing Cell Line Services for LPAR6
- GenScript: Design CRISPR guide RNA sequences for LPAR6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LPAR6
- Sino Biological Human cDNA Clone for LPAR6
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LPAR6
- Novus Biologicals proteins for LPAR6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for LPAR6
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for LPAR6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for LPAR6
- Cyagen custom Knockout/knockin (KOKI) mouse models for LPAR6
- VectorBuilder custom plasmid, inducible vectors for LPAR6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LPAR6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LPAR6
- antibodies-online: Search results for 40 available LPAR6 Antibodies ranked by validation data
- Compare Top LPAR6 Antibodies
- antibodies-online: Search results for available LPAR6 related products ranked by validation data
- antibodies-online: Search results for 3 available LPAR6 Proteins ranked by validation data
- Compare Top LPAR6 Proteins
- Quality Products:
- GeneTex LPAR6 Antibody for LPAR6
- Search GeneTex for Proteins for LPAR6
- Horizon Cell Lines for LPAR6
- genomics-online: cdna clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- orf clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- genomics-online: gRNA clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- genomics-online: primer clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- genomics-online: shRNA clones - Search results for 112 available LPAR6 gene related products
- Overview of 112 available LPAR6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR6
- GeneCopoeia miRNA 3'UTR Target clone products for LPAR6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR6
Sources for LPAR6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt