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The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
LPAR6 (Lysophosphatidic Acid Receptor 6) is a Protein Coding gene. Diseases associated with LPAR6 include Hypotrichosis 8 and Familial Woolly Hair Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is LPAR4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0070915 | lysophosphatidic acid receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Nucleotide-like (purinergic) receptors |
.01
.01
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4 | RET signaling | ||
5 | Pathways in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001835 | blastocyst hatching | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0035025 | positive regulation of Rho protein signal transduction | IBA | 21873635 |
GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Promethazine | Approved, Investigational | Pharma | Target, inhibitor | 470 | ||
cyclic amp | Experimental | Pharma | 0 | |||
MC-1 | Investigational | Pharma | 0 | |||
1-Oleoyl lysophosphatidic acid sodium salt | Pharma | Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 | 0 | |||
H2L 5765834 | Pharma | LPA1,3,5 antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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LysoPA(0:0/16:0) |
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LysoPA(0:0/18:0) |
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LysoPA(0:0/18:1(9Z)) |
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LysoPA(0:0/18:2(9Z,12Z)) |
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LysoPA(16:0/0:0) |
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Compound | Action | Cas Number |
---|---|---|
1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of LPA1 and LPA2 | 325465-93-8 |
2-Methylthioadenosine diphosphate trisodium salt | Potent agonist for P2Y1, P2Y12 and P2Y13 | 475193-31-8 |
GRI 977143 | Selective LPA2 receptor non-lipid agonist | 325850-81-5 |
H2L 5765834 | LPA1,3,5 antagonist | 420841-84-5 |
H2L5186303 | Potent and selective LPA2 receptor antagonist | 139262-76-3 |
MRS 2365 | Highly potent and selective P2Y1 agonist | 436847-09-5 |
MRS 2690 | Potent P2Y14 agonist | 15039-58-4 |
MRS 2693 trisodium salt | Selective P2Y6 agonist | 1448858-83-0 |
PSB 0474 | Potent and selective P2Y6 agonist | 917567-60-3 |
TC LPA5 4 | LPA5 receptor antagonist | 1393814-38-4 |
Compound | Action | Cas Number |
---|---|---|
1-Oleoyl lysophosphatidic acid sodium salt | Activates LPA receptor | 325465-93-8 |
H2L 5765834 | 420841-84-5 | |
H2L5186303 | 139262-76-3 | |
Ki16198 | LPA antagonist | 355025-13-7 |
Ki16425 | LPA receptor antagonist | 355025-24-0 |
TC LPA5 4 | 1393814-38-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | LPAR6 30 31 |
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OneToOne | |
Dog (Canis familiaris) |
Mammalia | LPAR6 30 31 |
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OneToOne | |
Cow (Bos Taurus) |
Mammalia | P2RY5 31 |
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OneToOne | |
LPAR6 30 |
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Oppossum (Monodelphis domestica) |
Mammalia | LPAR6 31 |
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OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lpar6 30 17 31 |
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OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lpar6 30 |
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Chicken (Gallus gallus) |
Aves | LPAR6 30 |
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-- 31 |
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ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | LPAR6 31 |
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OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lpar6 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | lpar6a 30 31 |
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OneToMany | |
lpar6b 31 |
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OneToMany |
SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769847 | Benign: not provided | 48,411,839(-) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
774331 | Conflicting Interpretations: Retinoblastoma; not provided | 48,411,503(-) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
780057 | Likely Benign: not provided | 48,411,623(-) | T/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
791427 | Likely Benign: not provided | 48,412,250(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
802971 | Likely Benign: Retinoblastoma | 48,411,605(-) | G/T | NONSENSE,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1649n100 | CNV | gain | 25217958 |
esv1206120 | CNV | deletion | 17803354 |
esv1248194 | CNV | deletion | 17803354 |
esv2747378 | CNV | deletion | 23290073 |
esv2747379 | CNV | deletion | 23290073 |
esv2747380 | CNV | deletion | 23290073 |
esv29390 | CNV | gain | 19812545 |
nsv1050786 | CNV | gain | 25217958 |
nsv1122816 | CNV | deletion | 24896259 |
nsv832602 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
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hypotrichosis 8 |
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familial woolly hair syndrome |
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hypotrichosis simplex |
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hypotrichosis |
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retinoblastoma |
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