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The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] See more...
Aliases for LPAR6 Gene
Aliases for LPAR6 Gene
External Ids for LPAR6 Gene
- HGNC: 15520
- Entrez Gene: 10161
- Ensembl: ENSG00000139679
- OMIM: 609239
- UniProtKB: P43657
Previous HGNC Symbols for LPAR6 Gene
- P2RY5
Previous GeneCards Identifiers for LPAR6 Gene
- GC13M047885
- GC13M048963
- GC13M029777
Summaries for LPAR6 Gene
-
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
GeneCards Summary for LPAR6 Gene
LPAR6 (Lysophosphatidic Acid Receptor 6) is a Protein Coding gene. Diseases associated with LPAR6 include Hypotrichosis 8 and Familial Woolly Hair Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is LPAR4.
UniProtKB/Swiss-Prot Summary for LPAR6 Gene
-
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
Additional gene information for LPAR6 Gene
- HGNC(15520)
- Entrez Gene(10161)
- Ensembl(ENSG00000139679)
- OMIM(609239)
- UniProtKB(P43657)
- Open Targets Platform(ENSG00000139679)
- Monarch Initiative
- Search for LPAR6 at DataMed
- Search for LPAR6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPAR6 Gene
Genomics for LPAR6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LPAR6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LPAR6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPAR6
Genomic Locations for LPAR6 Gene
Genomic Locations for LPAR6 Gene
- chr13:48,389,567-48,444,704
- (GRCh38/hg38)
- Size:
- 55,138 bases
- Orientation:
- Minus strand
- chr13:48,963,707-49,018,840
- (GRCh37/hg19)
- Size:
- 55,134 bases
- Orientation:
- Minus strand
Genomic View for LPAR6 Gene
Genes around LPAR6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q14.2 by HGNC
- 13q14.2 by Entrez Gene
- 13q14.2 by Ensembl
LPAR6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LPAR6 Gene
Proteins for LPAR6 Gene
-
Protein details for LPAR6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43657-LPAR6_HUMAN
- Recommended name:
- Lysophosphatidic acid receptor 6
- Protein Accession:
- P43657
- A4FTW9
- B3KVF2
- F2YGU4
- O15133
- Q3KPF5
- Q53FA0
- Q5VW44
- Q7Z3S0
- Q7Z3S6
Protein attributes for LPAR6 Gene
- Size:
- 344 amino acids
- Molecular mass:
- 39392 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=L11910; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- This is a nested gene within intron 17 of the retinoblastoma gene.
Protein Expression for LPAR6 Gene
Post-translational modifications for LPAR6 Gene
Other Protein References for LPAR6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences LPAR6 / P2RY5 / P2Y5 Antibody (LS-A850) and LPAR6 / P2RY5 / P2Y5 Antibody (LS-A852)
- G Biosciences Immunotag™ P2RY5 Antibody
- Creative Diagnostics Anti-LPAR6 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for LPAR6
- Novus Biologicals Antibodies for LPAR6
-
Abcam antibodies for LPAR6
- Invitrogen Antibodies for LPAR6 (AFLGC-LPAR6)
-
Boster Bio Antibodies for LPAR6
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LPAR6
- Origene Custom Protein Services for LPAR6
- Novus Biologicals proteins for LPAR6
- antibodies-online: Show 3 available LPAR6 Proteins ranked by validation data
- Compare Top LPAR6 Proteins
-
Quality Products:
No data available for DME Specific Peptides for LPAR6 Gene
Domains & Families for LPAR6 Gene
Gene Families for LPAR6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- G-protein coupled receptors
- Potential drug targets
- Predicted membrane proteins
Protein Domains for LPAR6 Gene
- InterPro:
- Blocks:
-
- P2 purinoceptor signature
- P2Y5 purinoceptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for LPAR6 Gene
- GenScript: Design optimal peptide antigens:
-
- Purinergic receptor P2Y G protein-coupled protein 5 (F2YGU4_HUMAN)
- RB intron encoded G-protein coupled receptor (LPAR6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P43657- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for LPAR6 Gene
Molecular function for LPAR6 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
Phenotypes From GWAS Catalog for LPAR6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
| GO:0070915 | lysophosphatidic acid receptor activity | IBA | 21873635 |
Phenotypes for LPAR6 Gene
- MGI mutant phenotypes for LPAR6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LPAR6:
Animal Models for LPAR6 Gene
- MGI Knock Outs for LPAR6:
-
- Lpar6 Lpar6<tm1.1(KOMP)Vlcg>
Animal Model Products
-
Taconic Biosciences Mouse Models for LPAR6
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LPAR6 - Select products 50% OFF >
- * LPAR6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LPAR6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR6
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPAR6
miRNA for LPAR6 Gene
- miRTarBase miRNAs that target LPAR6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR6
- Browse OriGene Inhibitory RNA Products For LPAR6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR6
Clone Products
- Applied Biological Materials (abm): Clones for LPAR6 - Select products 50% OFF >
- * LPAR6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205172
- MR205172
- MR205172L3
- MR205172L4
- RC207345
- RC207345L1
- RC207345L2
- RC207345L3
- RC207345L4
- RC228834
- RC228834L1
- RC228834L2
- RC228834L3
- RC228834L4
- RC228835
- RC228835L1
- RC228835L2
- RC228835L3
- RC228835L4
- RG207345
- RG228834
- RG228835
- RR207566
- RR207566L3
- RR207566L4
- MR205172L3V
- MR205172L4V
- RC207345L1V
- RC207345L2V
- RC207345L3V
- RC207345L4V
- RC228834L1V
- RC228834L2V
- RC228834L3V
- RC228834L4V
- RC228835L1V
- RC228835L2V
- RC228835L3V
- RC228835L4V
- RR207566L3V
- RR207566L4V
- RC402790
- RC402791
- RC402792
- RC402793
- RC402794
- RC402795
- RC402796
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LPAR6
- Addgene plasmids for LPAR6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR6
Cell Line Products
-
Horizon Cell Lines for LPAR6
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LPAR6 Gene
Localization for LPAR6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LPAR6 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPAR6 Gene
Pathways & Interactions for LPAR6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Nucleotide-like (purinergic) receptors |
.01
.01
|
|
| 4 | RET signaling | ||
| 5 | Pathways in cancer | ||
Pathways by source for LPAR6 Gene
2 BioSystems pathways for LPAR6 Gene
4 KEGG pathways for LPAR6 Gene
Interacting Proteins for LPAR6 Gene
Selected Interacting proteins:
P43657-LPAR6_HUMAN
ENSP00000367691
for LPAR6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LPAR6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001835 | blastocyst hatching | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0035025 | positive regulation of Rho protein signal transduction | IBA | 21873635 |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | IBA | 21873635 |
Drugs & Compounds for LPAR6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Promethazine | Approved, Investigational | Pharma | Target, inhibitor | 470 | ||
| cyclic amp | Experimental | Pharma | 0 | |||
| MC-1 | Investigational | Pharma | 0 | |||
| 1-Oleoyl lysophosphatidic acid sodium salt | Pharma | Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 | 0 | |||
| H2L 5765834 | Pharma | LPA1,3,5 antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| LysoPA(0:0/16:0) |
|
|
||||
| LysoPA(0:0/18:0) |
|
|
|
|||
| LysoPA(0:0/18:1(9Z)) |
|
|
||||
| LysoPA(0:0/18:2(9Z,12Z)) |
|
|
|
|||
| LysoPA(16:0/0:0) |
|
|
(10) Tocris Compounds for LPAR6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of LPA1 and LPA2 | 325465-93-8 |
| 2-Methylthioadenosine diphosphate trisodium salt | Potent agonist for P2Y1, P2Y12 and P2Y13 | 475193-31-8 |
| GRI 977143 | Selective LPA2 receptor non-lipid agonist | 325850-81-5 |
| H2L 5765834 | LPA1,3,5 antagonist | 420841-84-5 |
| H2L5186303 | Potent and selective LPA2 receptor antagonist | 139262-76-3 |
| MRS 2365 | Highly potent and selective P2Y1 agonist | 436847-09-5 |
| MRS 2690 | Potent P2Y14 agonist | 15039-58-4 |
| MRS 2693 trisodium salt | Selective P2Y6 agonist | 1448858-83-0 |
| PSB 0474 | Potent and selective P2Y6 agonist | 917567-60-3 |
| TC LPA5 4 | LPA5 receptor antagonist | 1393814-38-4 |
(6) ApexBio Compounds for LPAR6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Oleoyl lysophosphatidic acid sodium salt | Activates LPA receptor | 325465-93-8 |
| H2L 5765834 | 420841-84-5 | |
| H2L5186303 | 139262-76-3 | |
| Ki16198 | LPA antagonist | 355025-13-7 |
| Ki16425 | LPA receptor antagonist | 355025-24-0 |
| TC LPA5 4 | 1393814-38-4 |
Transcripts for LPAR6 Gene
mRNA/cDNA for LPAR6 Gene
- 5 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000345941 2428 nts (view in UCSC)
- ENST00000378434 3004 nts (view in UCSC)
- ENST00000462781 356 nts (view in UCSC)
- ENST00000464486 374 nts (view in UCSC)
- ENST00000465365 1651 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LPAR6 - Select products 50% OFF >
- * LPAR6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LPAR6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR6
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPAR6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR6
- Browse OriGene Inhibitory RNA Products For LPAR6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR6
Clone Products
- Applied Biological Materials (abm): Clones for LPAR6 - Select products 50% OFF >
- * LPAR6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205172
- MR205172
- MR205172L3
- MR205172L4
- RC207345
- RC207345L1
- RC207345L2
- RC207345L3
- RC207345L4
- RC228834
- RC228834L1
- RC228834L2
- RC228834L3
- RC228834L4
- RC228835
- RC228835L1
- RC228835L2
- RC228835L3
- RC228835L4
- RG207345
- RG228834
- RG228835
- RR207566
- RR207566L3
- RR207566L4
- MR205172L3V
- MR205172L4V
- RC207345L1V
- RC207345L2V
- RC207345L3V
- RC207345L4V
- RC228834L1V
- RC228834L2V
- RC228834L3V
- RC228834L4V
- RC228835L1V
- RC228835L2V
- RC228835L3V
- RC228835L4V
- RR207566L3V
- RR207566L4V
- RC402790
- RC402791
- RC402792
- RC402793
- RC402794
- RC402795
- RC402796
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LPAR6
- Addgene plasmids for LPAR6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR6
Relevant External Links for LPAR6 Gene
- GeneLoc Exon Structure for
- LPAR6
Expression for LPAR6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
-
Placenta (Extraembryonic Tissues)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAR6 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPAR6
SOURCE GeneReport for Unigene cluster for LPAR6 Gene:
Hs.123464mRNA Expression by UniProt/SwissProt for LPAR6 Gene:
P43657-LPAR6_HUMAN
Tissue specificity:
Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for LPAR6 Gene
- Nervous system(4.5)
- Heart(4.4)
- Blood(4.4)
- Skin(2.6)
- Intestine(2.2)
- Lymph node(2.2)
- Spleen(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR6 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
Regions:
Head and neck:
- eye
- eyelid
- face
- forehead
- head
Limb:
- arm
- upper limb
General:
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs for LPAR6
-
OriGene qPCR primer pairs and template standards for LPAR6
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for LPAR6 Gene
Orthologs for LPAR6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LPAR6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LPAR6 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | P2RY5 31 |
|
OneToOne | |
| LPAR6 30 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | LPAR6 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lpar6 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lpar6 30 |
|
||
| Chicken (Gallus gallus) |
Aves | LPAR6 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | LPAR6 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lpar6 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lpar6a 30 31 |
|
OneToMany | |
| lpar6b 31 |
|
OneToMany |
- Species where no ortholog for LPAR6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LPAR6 Gene
- ENSEMBL:
- Gene Tree for LPAR6 (if available)
- TreeFam:
- Gene Tree for LPAR6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LPAR6: view image
Paralogs for LPAR6 Gene
Paralogs for LPAR6 Gene
(55) SIMAP similar genes for LPAR6 Gene using alignment to 1 proteins:
- LPAR6_HUMAN
- LPAR4
- CYSLTR1
- LPAR5
- KPG_010
- CCR5
- P2RY10
- GPR174
- CCR4
- AGTR2
- F2R
- AGTR1
- CCR2
- P2RY4
- P2RY2
- IL8RB
- CXCR2
- GPR17
- CXCR1
- SSTR4
- P2RY8
- P2RY1
- KPG_011
- GPR183
- CYSLTR2
- F2RL2
- CX3CR1
- XCR1
- PTAFR
- HCAR3
- CCR8
- CCR1
- P2RY12
- SSTR2
- OXGR1
- OPRK1
- HCAR2
- GPR68
- GPR65
- GPR18
- GPR35
- CCR6
- CCR3
- OPRL1
- GPR34
- P2RY14
- CXCR4
- CCR9
- CCBP2
- ACKR3
- SSTR1
- OPRM1
- GPR55
- P2RY6
- GPR4
- GPR171
Variants for LPAR6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPAR6 Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769847 | Benign: not provided | 48,411,839(-) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 774331 | Conflicting Interpretations: Retinoblastoma; not provided | 48,411,503(-) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
| 780057 | Likely Benign: not provided | 48,411,623(-) | T/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 791427 | Likely Benign: not provided | 48,412,250(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 802971 | Likely Benign: Retinoblastoma | 48,411,605(-) | G/T | NONSENSE,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1649n100 | CNV | gain | 25217958 |
| esv1206120 | CNV | deletion | 17803354 |
| esv1248194 | CNV | deletion | 17803354 |
| esv2747378 | CNV | deletion | 23290073 |
| esv2747379 | CNV | deletion | 23290073 |
| esv2747380 | CNV | deletion | 23290073 |
| esv29390 | CNV | gain | 19812545 |
| nsv1050786 | CNV | gain | 25217958 |
| nsv1122816 | CNV | deletion | 24896259 |
| nsv832602 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LPAR6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR6 Gene
Disorders for LPAR6 Gene
(21) MalaCards diseases for LPAR6 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypotrichosis 8 |
|
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| familial woolly hair syndrome |
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| hypotrichosis simplex |
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| hypotrichosis |
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| retinoblastoma |
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Search LPAR6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LPAR6_HUMAN- Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis. {ECO:0000269 PubMed:18297072}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. {ECO:0000269 PubMed:18297070}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LPAR6
- Human Genome Epidemiology Navigator
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No data available for Genatlas for LPAR6 Gene
Publications for LPAR6 Gene
- Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K … Ogilvie A (Biochimica et biophysica acta 2000) 2 3 4
- Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. (PMID: 18803659) Shimomura Y … Christiano AM (Experimental dermatology 2009) 3 23
- Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. (PMID: 19386608) Yanagida K … Ishii S (The Journal of biological chemistry 2009) 2 3
- G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. (PMID: 18297070) Pasternack SM … Betz RC (Nature genetics 2008) 3 4
- Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. (PMID: 18297072) Shimomura Y … Christiano AM (Nature genetics 2008) 3 4
ExternalLinks
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