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LPAR6 Gene(Protein Coding)

Lysophosphatidic Acid Receptor 6

GCID:
GC13M048389
GIFtS:
53
Genes Participants
UDN Logo

Aliases for LPAR6 Gene

Aliases for LPAR6 Gene

  • Lysophosphatidic Acid Receptor 6 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 5 2 3
  • Oleoyl-L-Alpha-Lysophosphatidic Acid Receptor 3 4
  • RB Intron Encoded G-Protein Coupled Receptor 3 4
  • Purinergic Receptor 5 3 4
  • P2Y Purinoceptor 5 3 4
  • LPA Receptor 6 3 4
  • P2RY5 3 4
  • LPA-6 3 4
  • P2Y5 3 4
  • Purinergic Receptor P2Y G Protein-Coupled Protein 5 3
  • G-Protein Coupled Purinergic Receptor P2Y5 3
  • ARWH1 3
  • HYPT8 3
  • LAH3 3

External Ids for LPAR6 Gene

Previous HGNC Symbols for LPAR6 Gene

  • P2RY5

Previous GeneCards Identifiers for LPAR6 Gene

  • GC13M047885
  • GC13M048963
  • GC13M029777

Summaries for LPAR6 Gene

Entrez Gene Summary for LPAR6 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for LPAR6 Gene

LPAR6 (Lysophosphatidic Acid Receptor 6) is a Protein Coding gene. Diseases associated with LPAR6 include Hypotrichosis 8 and Woolly Hair Syndrome. Among its related pathways are Nucleotide-like (purinergic) receptors and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is LPAR4.

UniProtKB/Swiss-Prot for LPAR6 Gene

  • Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.

Gene Wiki entry for LPAR6 Gene

Additional gene information for LPAR6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR6 Gene

Genomics for LPAR6 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for LPAR6 Gene

Promoters and enhancers for LPAR6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13I048409 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.3 +33.2 33186 4.9 ELF3 FOXA2 MLX ARID4B FEZF1 RAD21 RARA YY1 SLC30A9 CREM LPAR6 RB1 GC13M048388 ENSG00000277233 GC13M048356
GH13I048446 Enhancer 0.6 Ensembl ENCODE 556.1 -2.0 -1986 1.3 JUND JUN FOS LPAR6 PIR51921 RB1
GH13I048444 Promoter 0.6 EPDnew 550.8 +0.0 24 0.1 MAFK LPAR6 GC13M048388 RB1
GH13I048426 Promoter 0.5 EPDnew 550.4 +17.8 17776 0.1 LPAR6 GC13M048388 ENSG00000277233 GC13M048356 RB1
GH13I048230 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.4 +210.2 210211 7.7 ATF1 FOXA2 SIN3A FEZF1 IRF4 ZNF48 YY1 ZNF207 ZNF143 ATF7 ITM2B MED4 LPAR6 RB1 LINC00441
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LPAR6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LPAR6 Gene

Genomic Locations for LPAR6 Gene
chr13:48,389,567-48,444,704
(GRCh38/hg38)
Size:
55,138 bases
Orientation:
Minus strand
chr13:48,963,707-49,018,840
(GRCh37/hg19)

Genomic View for LPAR6 Gene

Genes around LPAR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LPAR6 Gene

Proteins for LPAR6 Gene

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  1. Antibody
  2. Protein
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  • Protein details for LPAR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43657-LPAR6_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 6
    Protein Accession:
    P43657
    Secondary Accessions:
    • A4FTW9
    • B3KVF2
    • F2YGU4
    • O15133
    • Q3KPF5
    • Q53FA0
    • Q5VW44
    • Q7Z3S0
    • Q7Z3S6

    Protein attributes for LPAR6 Gene

    Size:
    344 amino acids
    Molecular mass:
    39392 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This is a nested gene within intron 17 of the retinoblastoma gene.
    SequenceCaution:
    • Sequence=L11910; Type=Frameshift; Positions=31; Evidence={ECO:0000305};

neXtProt entry for LPAR6 Gene

Protein Expression for LPAR6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LPAR6 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LPAR6 Gene

Domains & Families for LPAR6 Gene

Gene Families for LPAR6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • G-protein coupled receptors
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for LPAR6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LPAR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43657

UniProtKB/Swiss-Prot:

LPAR6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR6: view

Function for LPAR6 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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  6. Cell Line

Molecular function for LPAR6 Gene

UniProtKB/Swiss-Prot Function:
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.

Gene Ontology (GO) - Molecular Function for LPAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0070915 lysophosphatidic acid receptor activity IBA --
genes like me logo Genes that share ontologies with LPAR6: view
genes like me logo Genes that share phenotypes with LPAR6: view

Human Phenotype Ontology for LPAR6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LPAR6 Gene

MGI Knock Outs for LPAR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR6

miRNA for LPAR6 Gene

miRTarBase miRNAs that target LPAR6

Clone Products

  • Addgene plasmids for LPAR6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for LPAR6 Gene

Localization for LPAR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with LPAR6: view

Pathways & Interactions for LPAR6 Gene

genes like me logo Genes that share pathways with LPAR6: view

Gene Ontology (GO) - Biological Process for LPAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA --
genes like me logo Genes that share ontologies with LPAR6: view

No data available for SIGNOR curated interactions for LPAR6 Gene

Drugs & Compounds for LPAR6 Gene

Products:

  1. Drug

(11) Drugs for LPAR6 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
MC-1 Investigational Pharma 0
H2L 5765834 Pharma LPA1,3,5 antagonist 0
H2L5186303 Pharma Potent and selective LPA2 receptor antagonist 0
TC LPA5 4 Pharma LPA5 receptor antagonist 0

(13) Additional Compounds for LPAR6 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(10) Tocris Compounds for LPAR6 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(6) ApexBio Compounds for LPAR6 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR6: view

Drug Products

Transcripts for LPAR6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LPAR6 Gene

(3) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPAR6 Gene

Lysophosphatidic acid receptor 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for LPAR6

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR6 Gene

No ASD Table

Relevant External Links for LPAR6 Gene

GeneLoc Exon Structure for
LPAR6
ECgene alternative splicing isoforms for
LPAR6

Expression for LPAR6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPAR6 Gene

mRNA expression in normal human tissues for LPAR6 Gene
mRNA expression by GTEx for LPAR6 GenemRNA expression by BioGPS for LPAR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPAR6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPAR6 Gene



Protein tissue co-expression partners for LPAR6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LPAR6 Gene:

LPAR6

SOURCE GeneReport for Unigene cluster for LPAR6 Gene:

Hs.123464

mRNA Expression by UniProt/SwissProt for LPAR6 Gene:

P43657-LPAR6_HUMAN
Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henles and Huxleys layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for LPAR6 Gene

  • Blood(4.2)
  • Heart(4.2)
  • Nervous system(4.2)
  • Skin(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • forehead
  • head
Limb:
  • arm
  • upper limb
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with LPAR6: view

No data available for mRNA differential expression in normal tissues for LPAR6 Gene

Orthologs for LPAR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LPAR6 33 34
  • 100 (n)
dog
(Canis familiaris)
 Mammalia LPAR6 33 34
  • 91.46 (n)
cow
(Bos Taurus)
 Mammalia P2RY5 34
  • 89 (a)
 OneToOne
LPAR6 33
  • 88 (n)
oppossum
(Monodelphis domestica)
 Mammalia LPAR6 34
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Lpar6 33 16 34
  • 87.76 (n)
rat
(Rattus norvegicus)
 Mammalia Lpar6 33
  • 87.17 (n)
chicken
(Gallus gallus)
 Aves LPAR6 33
  • 72.01 (n)
-- 34
  • 18 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia LPAR6 34
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lpar6 33
  • 73.31 (n)
zebrafish
(Danio rerio)
 Actinopterygii lpar6a 33 34
  • 62.03 (n)
lpar6b 34
  • 56 (a)
 OneToMany
Species where no ortholog for LPAR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR6 Gene

ENSEMBL:
Gene Tree for LPAR6 (if available)
TreeFam:
Gene Tree for LPAR6 (if available)

Paralogs for LPAR6 Gene

Variants for LPAR6 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for LPAR6 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs115596308 pathogenic, Hypotrichosis 8 48,411,837(-) G/A/C/T coding_sequence_variant, missense_variant
rs121434306 pathogenic, Hypotrichosis 8 48,411,961(-) G/A coding_sequence_variant, stop_gained
rs121434307 pathogenic, Autosomal recessive woolly hair 1, with or without hypotrichosis, Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150] 48,411,862(-) T/A/C coding_sequence_variant, missense_variant
rs121434308 conflicting-interpretations-of-pathogenicity, Hypotrichosis 8 48,411,988(-) C/T coding_sequence_variant, missense_variant
rs121434309 pathogenic, Hypotrichosis 8, Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150] 48,411,859(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for LPAR6 Gene

Variant ID Type Subtype PubMed ID
dgv1649n100 CNV gain 25217958
esv1206120 CNV deletion 17803354
esv1248194 CNV deletion 17803354
esv2747378 CNV deletion 23290073
esv2747379 CNV deletion 23290073
esv2747380 CNV deletion 23290073
esv29390 CNV gain 19812545
nsv1050786 CNV gain 25217958
nsv1122816 CNV deletion 24896259
nsv832602 CNV loss 17160897

Variation tolerance for LPAR6 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPAR6 Gene

Human Gene Mutation Database (HGMD)
LPAR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR6 Gene

Disorders for LPAR6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for LPAR6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 8
  • hypt8
woolly hair syndrome
  • familial woolly hair
hypotrichosis simplex
  • hhs
hypotrichosis
hypotrichosis 6
  • hypt6
- elite association - COSMIC cancer census association via MalaCards
Search LPAR6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LPAR6_HUMAN
  • Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. {ECO:0000269 PubMed:18297070}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis. {ECO:0000269 PubMed:18297072}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LPAR6

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LPAR6: view

No data available for Genatlas for LPAR6 Gene

Publications for LPAR6 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K … Ogilvie A (Biochimica et biophysica acta 2000) 2 3 4 58
  2. Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. (PMID: 18803659) Shimomura Y … Christiano AM (Experimental dermatology 2009) 3 22 58
  3. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. (PMID: 19386608) Yanagida K … Ishii S (The Journal of biological chemistry 2009) 2 3 58
  4. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. (PMID: 18297070) Pasternack SM … Betz RC (Nature genetics 2008) 3 4 58
  5. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. (PMID: 18297072) Shimomura Y … Christiano AM (Nature genetics 2008) 3 4 58

Products for LPAR6 Gene

  • Addgene plasmids for LPAR6

Sources for LPAR6 Gene

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