This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009] See more...

Aliases for LPAR4 Gene

Aliases for LPAR4 Gene

  • Lysophosphatidic Acid Receptor 4 2 3 4 5
  • P2RY9 2 3 4
  • LPA4 2 3 4
  • P2Y9 2 3 4
  • G-Protein Coupled Receptor 23 3 4
  • Purinergic Receptor 9 3 4
  • P2Y Purinoceptor 9 3 4
  • P2Y5-Like Receptor 3 4
  • LPA Receptor 4 3 4
  • P2Y5-LIKE 2 3
  • GPR23 3 4
  • LPA-4 3 4
  • G Protein-Coupled Receptor 23 2
  • LPAR4 5

External Ids for LPAR4 Gene

Previous HGNC Symbols for LPAR4 Gene

  • GPR23

Previous GeneCards Identifiers for LPAR4 Gene

  • GC0XP077896
  • GC0XP078004
  • GC0XP071584

Summaries for LPAR4 Gene

Entrez Gene Summary for LPAR4 Gene

  • This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]

GeneCards Summary for LPAR4 Gene

LPAR4 (Lysophosphatidic Acid Receptor 4) is a Protein Coding gene. Diseases associated with LPAR4 include Differentiated Thyroid Carcinoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and lipid binding. An important paralog of this gene is LPAR6.

UniProtKB/Swiss-Prot Summary for LPAR4 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Wiki entry for LPAR4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPAR4 Gene

Genomics for LPAR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LPAR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ078746 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 254.5 +0.2 218 3.4 POLR2A TAF1 LPAR4 HSALNG0138746-001 HSALNG0138746-002 ITM2A MAGT1 HSALNG0138747 P2RY10
GH0XJ078652 Promoter/Enhancer 1.3 EPDnew FANTOM5 ENCODE 250.2 -94.4 -94359 2.4 JUND YY1 TRIM22 FOXA2 RXRA RARA TEAD3 FOSL2 FOXP1 SPI1 LOC107985670 LPAR4 TAF9B CYSLTR1 RTL3
GH0XJ079142 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +403.1 403058 15.5 BCLAF1 TARDBP TRIM22 MAX BATF ELF1 SCRT1 ZNF24 IKZF1 MTA3 ITM2A P2RY10 GPR174 RTL3 LPAR4 lnc-P2RY10-1 HSALNG0138759
GH0XJ078768 Enhancer 0.3 Ensembl ENCODE 17.5 +21.9 21936 2.5 LPAR4 ITM2A TAF9B piR-56759-626 HSALNG0138749 P2RY10
GH0XJ079106 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 4.1 +360.8 360757 3.8 BCL11A SMARCA5 ELF1 FOXA1 IKZF1 NR2F1 ATF2 JUNB ZNF217 ARID3A lnc-GPR174-2 ITM2A GPR174 P2RY10 LPAR4 lnc-P2RY10-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPAR4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPAR4

Top Transcription factor binding sites by QIAGEN in the LPAR4 gene promoter:
  • AREB6
  • Cdc5
  • Chx10
  • FOXO1
  • FOXO1a
  • HSF1 (long)
  • HSF1short
  • RFX1
  • Sox9

Genomic Locations for LPAR4 Gene

Latest Assembly
chrX:78,747,658-78,758,714
(GRCh38/hg38)
Size:
11,057 bases
Orientation:
Plus strand

Previous Assembly
chrX:78,003,217-78,012,609
(GRCh37/hg19 by Entrez Gene)
Size:
9,393 bases
Orientation:
Plus strand

chrX:78,003,206-78,012,591
(GRCh37/hg19 by Ensembl)
Size:
9,386 bases
Orientation:
Plus strand

Genomic View for LPAR4 Gene

Genes around LPAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR4 Gene

Proteins for LPAR4 Gene

  • Protein details for LPAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99677-LPAR4_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 4
    Protein Accession:
    Q99677
    Secondary Accessions:
    • B2RAC7
    • O15132
    • Q502U9
    • Q6NSP5

    Protein attributes for LPAR4 Gene

    Size:
    370 amino acids
    Molecular mass:
    41895 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR4 Gene

Post-translational modifications for LPAR4 Gene

  • Glycosylation at Asn15, Asn24, Asn28, and Asn183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LPAR4 Gene

Domains & Families for LPAR4 Gene

Gene Families for LPAR4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for LPAR4 Gene

InterPro:
Blocks:
  • P2Y5 purinoceptor signature

Suggested Antigen Peptide Sequences for LPAR4 Gene

GenScript: Design optimal peptide antigens:
  • Purinergic receptor 9 (LPAR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99677

UniProtKB/Swiss-Prot:

LPAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR4: view

Function for LPAR4 Gene

Molecular function for LPAR4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Ontology (GO) - Molecular Function for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0008289 lipid binding IEA --
GO:0035727 lysophosphatidic acid binding IEA --
GO:0070915 lysophosphatidic acid receptor activity IBA 21873635
genes like me logo Genes that share ontologies with LPAR4: view
genes like me logo Genes that share phenotypes with LPAR4: view

Animal Models for LPAR4 Gene

MGI Knock Outs for LPAR4:
  • Lpar4 Lpar4<tm1.1(KOMP)Vlcg>
  • Lpar4 Lpar4<tm1Sati>

Animal Models for research

  • Taconic Biosciences Mouse Models for LPAR4

miRNA for LPAR4 Gene

miRTarBase miRNAs that target LPAR4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR4 Gene

Localization for LPAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR4 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with LPAR4: view

Pathways & Interactions for LPAR4 Gene

genes like me logo Genes that share pathways with LPAR4: view

SIGNOR curated interactions for LPAR4 Gene

Gene Ontology (GO) - Biological Process for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0035025 positive regulation of Rho protein signal transduction IBA 21873635
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with LPAR4: view

Drugs & Compounds for LPAR4 Gene

(15) Drugs for LPAR4 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Promethazine Approved, Investigational Pharma Target, inhibitor 494
farnesyl diphosphate Experimental Pharma Antagonist 0
MC-1 Investigational Pharma 0
1-Oleoyl lysophosphatidic acid sodium salt Pharma Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 0
H2L 5765834 Pharma LPA1,3,5 antagonist 0

(10) Additional Compounds for LPAR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPA(0:0/16:0)
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic acid(0:0/16:0)
  • LPA(16:0)
  • 2-Hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
  • Lysophosphatidic acid(18:0)
  • 2-Stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic acid(0:0/18:1)
  • 2-Oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic acid(18:2)
LysoPA(16:0/0:0)
  • 1-Hexadecanoyl-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-sn-glycero-3-phosphoric acid
  • 1-Palmitoylglycerol 3-phosphoric acid
  • 1-Palmitoyl-sn-glycerol 3-phosphate
  • PLPA

(5) Tocris Compounds for LPAR4 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(6) ApexBio Compounds for LPAR4 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR4: view

Drug products for research

Transcripts for LPAR4 Gene

mRNA/cDNA for LPAR4 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR4

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR4 Gene

No ASD Table

Relevant External Links for LPAR4 Gene

GeneLoc Exon Structure for
LPAR4

Expression for LPAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPAR4 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR4 Gene

This gene is overexpressed in Ovary (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPAR4

SOURCE GeneReport for Unigene cluster for LPAR4 Gene:

Hs.522701

mRNA Expression by UniProt/SwissProt for LPAR4 Gene:

Q99677-LPAR4_HUMAN
Tissue specificity: High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.

Evidence on tissue expression from TISSUES for LPAR4 Gene

  • Nervous system(4.3)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with LPAR4: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR4 Gene

Orthologs for LPAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LPAR4 29 30
  • 99.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LPAR4 29 30
  • 93.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LPAR4 29 30
  • 92.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lpar4 29 16 30
  • 90.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lpar4 29
  • 90.36 (n)
Oppossum
(Monodelphis domestica)
Mammalia LPAR4 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LPAR4 29 30
  • 75.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LPAR4 30
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lpar4 29
  • 74.26 (n)
Str.9558 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.25260 29
Zebrafish
(Danio rerio)
Actinopterygii LOC794698 29
  • 65.69 (n)
zgc:172079 30
  • 30 (a)
ManyToMany
Species where no ortholog for LPAR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LPAR4 Gene

ENSEMBL:
Gene Tree for LPAR4 (if available)
TreeFam:
Gene Tree for LPAR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPAR4: view image
Alliance of Genome Resources:
Additional Orthologs for LPAR4

Paralogs for LPAR4 Gene

genes like me logo Genes that share paralogs with LPAR4: view

Variants for LPAR4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPAR4 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs143714219 Benign: not provided 78,755,029(+) C/A
NM_005296.3(LPAR4):c.160C>A (p.Leu54Met)
MISSENSE
rs148919808 Likely Benign: not provided 78,755,002(+) G/A
NM_005296.3(LPAR4):c.133G>A (p.Val45Ile)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LPAR4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LPAR4 Gene

Variant ID Type Subtype PubMed ID
dgv517n21 CNV gain 19592680

Variation tolerance for LPAR4 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPAR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR4
Leiden Open Variation Database (LOVD)
LPAR4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR4 Gene

Disorders for LPAR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LPAR4 Gene - From: ORP

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search LPAR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LPAR4

genes like me logo Genes that share disorders with LPAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPAR4 Gene

Publications for LPAR4 Gene

  1. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. (PMID: 9223435) Janssens R … Communi D (Biochemical and biophysical research communications 1997) 3 4 22
  2. Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations. (PMID: 26941397) Pan W … Lin D (Human molecular genetics 2016) 3 72
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for LPAR4 Gene

Sources for LPAR4 Gene