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This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008] See more...
Aliases for LPAR3 Gene
Aliases for LPAR3 Gene
External Ids for LPAR3 Gene
- HGNC: 14298
- NCBI Entrez Gene: 23566
- Ensembl: ENSG00000171517
- OMIM®: 605106
- UniProtKB/Swiss-Prot: Q9UBY5
Previous HGNC Symbols for LPAR3 Gene
- EDG7
Previous GeneCards Identifiers for LPAR3 Gene
- GC01M085048
- GC01M085277
- GC01M083389
Summaries for LPAR3 Gene
-
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for LPAR3 Gene
LPAR3 (Lysophosphatidic Acid Receptor 3) is a Protein Coding gene. Diseases associated with LPAR3 include Trachea Adenoid Cystic Carcinoma and Tracheal Cancer. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phospholipid binding. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot Summary for LPAR3 Gene
-
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Additional gene information for LPAR3 Gene
- HGNC (14298)
- NCBI Entrez Gene (23566)
- Ensembl (ENSG00000171517)
- OMIM® (605106)
- UniProtKB/Swiss-Prot (Q9UBY5)
- Open Targets Platform(ENSG00000171517)
- Monarch Initiative
- Search for LPAR3 at DataMed
- Search for LPAR3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPAR3 Gene
Genomics for LPAR3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LPAR3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J084892 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 260.1 | +0.3 | 305 | 1.8 | ZEB1 ZIC2 ZNF610 ZNF623 SIN3A ZNF639 KLF7 ZNF341 ZNF433 KLF9 | LPAR3 HSALNG0004831-001 ZNHIT6 HSALNG0004829 SSX2IP | |
| GH01J084894 | Enhancer | 0.3 | Ensembl ENCODE | 259.7 | -1.9 | -1895 | 1.4 | LPAR3 HSALNG0004831-001 HSALNG0004831-002 MCOLN2 | ||
| GH01J084891 | Enhancer | 0.2 | Ensembl | 258.4 | +1.5 | 1505 | 0.2 | LPAR3 HSALNG0004829 SSX2IP | ||
| GH01J084851 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 16.6 | +39.4 | 39405 | 5.6 | BCL11A ZNF217 BHLHE40 CEBPB ZNF395 IRF4 TRIM22 GABPA CTBP1 FOSL1 | LPAR3 BCL10 GNG5 MCOLN2 C1orf52 HSALNG0004829 SSX2IP | |
| GH01J084846 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 15.8 | +44.8 | 44805 | 4 | ZNF217 ZIC2 ZNF610 MBD2 MAX ZNF341 RXRA ZNF843 FOXA2 PRDM6 | LPAR3 MCOLN2 GNG5 BCL10 C1orf52 HSALNG0004829 SSX2IP |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LPAR3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPAR3
- Top Transcription factor binding sites by QIAGEN in the LPAR3 gene promoter:
-
- AhR
- AP-2rep
- C/EBPalpha
- Evi-1
- Hlf
- Max1
- POU2F1
- POU2F1a
- Sox5
- STAT3
Genomic Locations for LPAR3 Gene
Latest Assembly
- chr1:84,811,601-84,893,206
- (GRCh38/hg38)
- Size:
- 81,606 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:85,277,285-85,358,889
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 81,605 bases
- Orientation:
- Minus strand
- chr1:85,277,285-85,358,896
- (GRCh37/hg19 by Ensembl)
- Size:
- 81,612 bases
- Orientation:
- Minus strand
Genomic View for LPAR3 Gene
Genes around LPAR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by HGNC
- 1p22.3 by Entrez Gene
- 1p22.3 by Ensembl
LPAR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LPAR3 Gene
Proteins for LPAR3 Gene
-
Protein details for LPAR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBY5-LPAR3_HUMAN
- Recommended name:
- Lysophosphatidic acid receptor 3
- Protein Accession:
- Q9UBY5
- A0AVA3
Protein attributes for LPAR3 Gene
- Size:
- 353 amino acids
- Molecular mass:
- 40128 Da
- Quaternary structure:
- No Data Available
Protein Expression for LPAR3 Gene
Post-translational modifications for LPAR3 Gene
Other Protein References for LPAR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences LPAR3 / LPA3 / EDG7 Antibody (LS-A1014) and LPAR3 / LPA3 / EDG7 Antibody (LS-B1594)
-
Custom Antibody ServicesOriGene Antibodies for LPAR3
- Novus Biologicals Antibodies for LPAR3
- Invitrogen Antibodies for LPAR3 (AFLGC-Lpar3)
- antibodies-online: Show 26 available LPAR3 Antibodies ranked by validation data
- Compare Top LPAR3 Antibodies
-
Recommended
- 54 WB Antibodies (anti-human)
- 13 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 30 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 21 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for LPAR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for LPAR3
Protein products for research
-
OriGene Purified Proteins for LPAR3
- Search Origene for MassSpec and Protein Over-expression Lysates for LPAR3
- Origene Custom Protein Services for LPAR3
-
Abcam proteins for LPAR3
Assay products for research
- antibodies-online: Show 26 available LPAR3 Elisa Kits ranked by validation data
- Compare Top LPAR3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for LPAR3 Gene
Domains & Families for LPAR3 Gene
Gene Families for LPAR3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for LPAR3 Gene
- InterPro:
- Blocks:
-
- Lysophosphatidic acid receptor family signature
- EDG-7 lysophosphatidic acid receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for LPAR3 Gene
- GenScript: Design optimal peptide antigens:
-
- Lysophosphatidic acid receptor Edg-7 (LPAR3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBY5- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for LPAR3 Gene
Molecular function for LPAR3 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Phenotypes From GWAS Catalog for LPAR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001965 | G-protein alpha-subunit binding | IEA | -- |
| GO:0004930 | G protein-coupled receptor activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0005543 | phospholipid binding | IEA | -- |
| GO:0008289 | lipid binding | TAS | 10488122 |
Phenotypes for LPAR3 Gene
- MGI mutant phenotypes for LPAR3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LPAR3:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- no effect
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased peripheral FA formation
- Decreased melanin production
- Decreased cell migration
Animal Models for LPAR3 Gene
- MGI Knock Outs for LPAR3:
-
- Lpar3 Lpar3<tm1Jch>
Animal Models for research
-
Taconic Biosciences Mouse Models for LPAR3
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for LPAR3 - Starting at $85 >
- * LPAR3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for LPAR3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR3
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPAR3
miRNA for LPAR3 Gene
- miRTarBase miRNAs that target LPAR3
-
- hsa-miR-1277-5p (MIRT506723)
- hsa-miR-190a-3p (MIRT506724)
- hsa-miR-5011-5p (MIRT506725)
- hsa-miR-8485 (MIRT506726)
- mmu-miR-30a-5p (MIRT592638)
- mmu-miR-30d-5p (MIRT592639)
- mmu-miR-30b-5p (MIRT592640)
- mmu-miR-30e-5p (MIRT592641)
- mmu-miR-384-5p (MIRT592642)
- mmu-miR-30c-5p (MIRT592643)
- mmu-miR-298-5p (MIRT600705)
- mmu-miR-882 (MIRT600706)
- mmu-miR-3473a (MIRT600707)
- mmu-miR-185-5p (MIRT600708)
- hsa-miR-448 (MIRT609695)
- hsa-miR-4789-5p (MIRT609696)
- hsa-miR-4643 (MIRT609697)
- hsa-miR-3941 (MIRT617885)
- hsa-miR-603 (MIRT617886)
- hsa-miR-362-3p (MIRT617887)
- hsa-miR-329-3p (MIRT617888)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR3
- Browse OriGene Inhibitory RNA Products For LPAR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR3
Clone products for research
- Applied Biological Materials (abm): Clones for LPAR3 - Starting at $45 >
- * LPAR3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for LPAR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR3
Cell Lines for research
-
Horizon Cell Lines for LPAR3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR3 Gene
Localization for LPAR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LPAR3 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10488122 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for LPAR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | Pathways in cancer | ||
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for LPAR3 Gene
1 BioSystems pathway for LPAR3 Gene
5 KEGG pathways for LPAR3 Gene
3 Qiagen pathways for LPAR3 Gene
- eNOS Signaling
- G12-G13 in Cellular Signaling
- RhoA Pathway
Interacting Proteins for LPAR3 Gene
Selected Interacting proteins:
Q9UBY5-LPAR3_HUMAN
ENSP00000395389
for LPAR3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LPAR3
SIGNOR curated interactions for LPAR3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | 10488122 |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
Drugs & Compounds for LPAR3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| farnesyl diphosphate | Experimental | Pharma | Antagonist | 0 | ||
| Ki16425 | Pharma | LPA receptor antagonist | 0 | |||
| 1-Oleoyl lysophosphatidic acid sodium salt | Pharma | Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 | 0 | |||
| GRI 977143 | Pharma | LPA2 receptor non-lipid agonist, Selective LPA2 receptor non-lipid agonist | 0 | |||
| H2L 5765834 | Pharma | LPA1,3,5 antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| dioctanoy?àëlglycerol?àë pyrophos?àëphate |
|
Antagonist |
|
|||
| LysoPA(0:0/16:0) |
|
|
||||
| LysoPA(0:0/18:0) |
|
|
||||
| LysoPA(0:0/18:1(9Z)) |
|
|
||||
| LysoPA(0:0/18:2(9Z,12Z)) |
|
|
(5) Tocris Compounds for LPAR3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of LPA1 and LPA2 | 325465-93-8 |
| GRI 977143 | Selective LPA2 receptor non-lipid agonist | 325850-81-5 |
| H2L 5765834 | LPA1,3,5 antagonist | 420841-84-5 |
| H2L5186303 | Potent and selective LPA2 receptor antagonist | 139262-76-3 |
| TC LPA5 4 | LPA5 receptor antagonist | 1393814-38-4 |
(7) ApexBio Compounds for LPAR3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1-Oleoyl lysophosphatidic acid sodium salt | Activates LPA receptor | 325465-93-8 |
| GRI 977143 | LPA2 receptor non-lipid agonist | 325850-81-5 |
| H2L 5765834 | 420841-84-5 | |
| H2L5186303 | 139262-76-3 | |
| Ki16198 | LPA antagonist | 355025-13-7 |
| Ki16425 | LPA receptor antagonist | 355025-24-0 |
| TC LPA5 4 | 1393814-38-4 |
Transcripts for LPAR3 Gene
mRNA/cDNA for LPAR3 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370611 3515 nts (view in UCSC)
- ENST00000440886 3345 nts (view in UCSC)
- ENST00000491034 871 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for LPAR3 - Starting at $85 >
- * LPAR3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for LPAR3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR3
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPAR3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPAR3
- Browse OriGene Inhibitory RNA Products For LPAR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR3
Clone products for research
- Applied Biological Materials (abm): Clones for LPAR3 - Starting at $45 >
- * LPAR3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for LPAR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR3
Relevant External Links for LPAR3 Gene
- GeneLoc Exon Structure for
- LPAR3
Expression for LPAR3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for LPAR3 Gene
This gene is overexpressed in Heart - Atrial Appendage (x6.4), Prostate (x4.1), and Testis (x4.1).
This gene is overexpressed in Neutrophil (35.1) and Liver (24.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAR3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPAR3
SOURCE GeneReport for Unigene cluster for LPAR3 Gene:
Hs.674915mRNA Expression by UniProt/SwissProt for LPAR3 Gene:
Q9UBY5-LPAR3_HUMAN
Tissue specificity:
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for LPAR3 Gene
- Blood(4.4)
- Intestine(2.2)
- Nervous system(2.2)
- Heart(2.1)
- Muscle(2.1)
Primer products for research
-
OriGene qPCR primer pairs for LPAR3
-
OriGene qPCR primer pairs and template standards for LPAR3
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR3 Gene
Orthologs for LPAR3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LPAR3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LPAR3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LPAR3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LPAR3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LPAR3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lpar3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lpar3 30 |
|
||
| Chicken (Gallus gallus) |
Aves | LPAR3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LPAR3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lpar3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lpar2a 30 |
|
- Species where no ortholog for LPAR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LPAR3 Gene
- ENSEMBL:
- Gene Tree for LPAR3 (if available)
- TreeFam:
- Gene Tree for LPAR3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LPAR3: view image
Paralogs for LPAR3 Gene
Paralogs for LPAR3 Gene
(10) SIMAP similar genes for LPAR3 Gene using alignment to 1 proteins:
- LPAR3_HUMAN
Variants for LPAR3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPAR3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs41289037 | Benign: not provided | 84,865,779(-) |
A/C NM_012152.3(LPAR3):c.342T>G (p.Thr114=) |
SYNONYMOUS | |
| rs58970370 | Benign: not provided | 84,814,046(-) |
C/T NM_012152.3(LPAR3):c.862G>A (p.Val288Met) |
MISSENSE | |
| rs61737670 | Benign: not provided | 84,814,083(-) |
T/C NM_012152.3(LPAR3):c.825A>G (p.Lys275=) |
SYNONYMOUS | |
| rs35745543 | - |
p.Arg231Gln |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.19;
52.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LPAR3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR3 Gene
Disorders for LPAR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| trachea adenoid cystic carcinoma |
|
|
| tracheal cancer |
|
|
| hutchinson-gilford progeria syndrome |
|
|
| trachea carcinoma |
|
|
| ovarian cancer |
|
|
Search LPAR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LPAR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LPAR3 Gene
Publications for LPAR3 Gene
- Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. (PMID: 10488122) Bandoh K … Inoue K (The Journal of biological chemistry 1999) 2 3 4 23
- Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PMID: 10727522) Im DS … Lynch KR (Molecular pharmacology 2000) 3 4 23
- Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PMID: 18840781) Grant SF … Hakonarson H (Diabetes 2009) 3 41
- Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. (PMID: 19001604) Yu S … Mills GB (Journal of the National Cancer Institute 2008) 3 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for LPAR3 Gene
- Custom Antibody ServicesOriGene Antibodies for LPAR3
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- Taconic Biosciences Mouse Models for LPAR3
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- Humanized Mice
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- VectorBuilder Custom and pre-made DNA vectors for LPAR3 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 26 available LPAR3 Antibodies ranked by validation data
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- 4 IHC (p) Antibodies (anti-mouse)
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- 21 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
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- antibodies-online: Show 26 available LPAR3 Elisa Kits ranked by validation data
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- antibodies-online: Show 7 available LPAR3 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for LPAR3
- Search Santa Cruz Biotechnology (SCBT) for LPAR3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LPAR3
- Custom Antibody ServicesProSci Antibodies for LPAR3
- Search for LPAR3 Proteins at ProSci
- Horizon Cell Lines for LPAR3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPAR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPAR3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LPAR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR3
Sources for LPAR3 Gene
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