LPAR3 Gene (Protein Coding)

Lysophosphatidic Acid Receptor 3

GC01M084811
GIFtS:
45
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008] See more...

Aliases for LPAR3 Gene

Aliases for LPAR3 Gene

  • Lysophosphatidic Acid Receptor 3 2 3 4 5
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 7 2 3
  • Lysophosphatidic Acid Receptor Edg-7 3 4
  • LPA Receptor 3 3 4
  • LPA-3 3 4
  • EDG7 3 4
  • LPA3 3 4
  • Calcium-Mobilizing Lysophosphatidic Acid Receptor LP-A3 3
  • Endothelial Cell Differentiation Gene 7 3
  • LPA Receptor EDG7 3
  • RP4-678I3 3
  • HOFNH30 3
  • Edg-7 3
  • LP-A3 3
  • GPCR 3

External Ids for LPAR3 Gene

Previous HGNC Symbols for LPAR3 Gene

  • EDG7

Previous GeneCards Identifiers for LPAR3 Gene

  • GC01M085048
  • GC01M085277
  • GC01M083389

Summaries for LPAR3 Gene

Entrez Gene Summary for LPAR3 Gene

  • This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for LPAR3 Gene

LPAR3 (Lysophosphatidic Acid Receptor 3) is a Protein Coding gene. Diseases associated with LPAR3 include Ovarian Cancer and Triple-Receptor Negative Breast Cancer. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phospholipid binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot Summary for LPAR3 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Gene Wiki entry for LPAR3 Gene

Additional gene information for LPAR3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPAR3 Gene

Genomics for LPAR3 Gene

GeneHancer (GH) Regulatory Elements for LPAR3 Gene

Promoters and enhancers for LPAR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J084892 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 510.1 +0.3 312 1.8 USF1 RBAK CTCF ZNF639 ZNF354C ZIC2 ZNF423 ZNF623 ZBTB26 ZNF510 LPAR3 HSALNG0004831 ENSG00000271576 C1orf52 ZNHIT6 SAMD13 LOC102724892
GH01J084896 Enhancer 0.4 Ensembl 500.7 -0.9 -888 0.2 EZH2 RNF2 SCRT2 HSALNG0004831 LPAR3 piR-59928-008
GH01J084895 Enhancer 0.3 ENCODE 500.7 -1.6 -1620 0.2 EZH2 STAT3 HSALNG0004831 LPAR3 piR-59928-008
GH01J084894 Enhancer 0.3 ENCODE 500.7 -1.5 -1460 0.2 EZH2 STAT3 HSALNG0004831 LPAR3 piR-59928-008
GH01J084851 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +39.6 39612 6 ZNF217 FOS EP300 CLOCK MEF2C TRIM22 CTBP1 BCL11A CBFB GABPA LPAR3 BCL10 GNG5 MCOLN2 C1orf52 LOC102724892
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPAR3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPAR3

Top Transcription factor binding sites by QIAGEN in the LPAR3 gene promoter:
  • AhR
  • AP-2rep
  • C/EBPalpha
  • Evi-1
  • Hlf
  • Max1
  • POU2F1
  • POU2F1a
  • Sox5
  • STAT3

Genomic Locations for LPAR3 Gene

Genomic Locations for LPAR3 Gene
chr1:84,811,602-84,893,213
(GRCh38/hg38)
Size:
81,612 bases
Orientation:
Minus strand
chr1:85,277,285-85,358,896
(GRCh37/hg19)
Size:
81,612 bases
Orientation:
Minus strand

Genomic View for LPAR3 Gene

Genes around LPAR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LPAR3 Gene

Proteins for LPAR3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LPAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBY5-LPAR3_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 3
    Protein Accession:
    Q9UBY5
    Secondary Accessions:
    • A0AVA3

    Protein attributes for LPAR3 Gene

    Size:
    353 amino acids
    Molecular mass:
    40128 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR3 Gene

Protein Expression for LPAR3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LPAR3 Gene

  • Glycosylation at Asn15 and Asn172
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LPAR3 Gene

Domains & Families for LPAR3 Gene

Gene Families for LPAR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for LPAR3 Gene

Blocks:
  • Lysophosphatidic acid receptor family signature
  • EDG-7 lysophosphatidic acid receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LPAR3 Gene

GenScript: Design optimal peptide antigens:
  • Lysophosphatidic acid receptor Edg-7 (LPAR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBY5

UniProtKB/Swiss-Prot:

LPAR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR3: view

Function for LPAR3 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for LPAR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Phenotypes From GWAS Catalog for LPAR3 Gene

Gene Ontology (GO) - Molecular Function for LPAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004930 G protein-coupled receptor activity TAS 10488122
GO:0005543 phospholipid binding IEA --
GO:0008289 lipid binding TAS 10488122
GO:0070915 lysophosphatidic acid receptor activity IEA --
genes like me logo Genes that share ontologies with LPAR3: view
genes like me logo Genes that share phenotypes with LPAR3: view

Animal Models for LPAR3 Gene

MGI Knock Outs for LPAR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR3 Gene

Localization for LPAR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10488122
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPAR3: view

Pathways & Interactions for LPAR3 Gene

genes like me logo Genes that share pathways with LPAR3: view

Pathways by source for LPAR3 Gene

1 BioSystems pathway for LPAR3 Gene
3 Qiagen pathways for LPAR3 Gene
  • eNOS Signaling
  • G12-G13 in Cellular Signaling
  • RhoA Pathway

SIGNOR curated interactions for LPAR3 Gene

Activates:

Gene Ontology (GO) - Biological Process for LPAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 10488122
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 10488122
genes like me logo Genes that share ontologies with LPAR3: view

Drugs & Compounds for LPAR3 Gene

Products:

  1. Drug

(30) Drugs for LPAR3 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Agonist, Antagonist 0
Ki16425 Pharma Antagonist LPA receptor antagonist 0
1-Oleoyl lysophosphatidic acid sodium salt Pharma Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 0
GRI 977143 Pharma LPA2 receptor non-lipid agonist, Selective LPA2 receptor non-lipid agonist 0
H2L 5765834 Pharma LPA1,3,5 antagonist 0

(19) Additional Compounds for LPAR3 Gene - From: IUPHAR, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-fluoromethylenephosphonate
Agonist
dioctanoy?aelglycerol?ae pyrophos?aephate
Antagonist
LysoPA(0:0/16:0)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic Acid(0:0/18:0)
  • Lysophosphatidic Acid(18:0)
  • 2-stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic Acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic Acid(0:0/18:1)
  • 2-oleoyl-glycero-3-phosphate

(5) Tocris Compounds for LPAR3 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(7) ApexBio Compounds for LPAR3 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
GRI 977143 LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR3: view

Drug Products

Transcripts for LPAR3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LPAR3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR3 Gene

No ASD Table

Relevant External Links for LPAR3 Gene

GeneLoc Exon Structure for
LPAR3

Expression for LPAR3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPAR3 Gene

mRNA expression in normal human tissues for LPAR3 Gene
mRNA expression by BioGPS for LPAR3 GenemRNA expression by GTEx for LPAR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPAR3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.4), Prostate (x4.1), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for LPAR3 Gene

This gene is overexpressed in Neutrophil (35.1) and Liver (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAR3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPAR3

SOURCE GeneReport for Unigene cluster for LPAR3 Gene:

Hs.674915

mRNA Expression by UniProt/SwissProt for LPAR3 Gene:

Q9UBY5-LPAR3_HUMAN
Tissue specificity: Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for LPAR3 Gene

  • Blood(4.3)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with LPAR3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR3 Gene

Orthologs for LPAR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LPAR3 31 30
  • 99.43 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia LPAR3 31 30
  • 90.65 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia LPAR3 31 30
  • 89.2 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia LPAR3 31
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia LPAR3 31
  • 85 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Lpar3 17 31 30
  • 84.8 (n)
rat
(Rattus norvegicus)
 Mammalia Lpar3 30
  • 84.4 (n)
chicken
(Gallus gallus)
 Aves LPAR3 31 30
  • 76.16 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia LPAR3 31
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lpar3 30
  • 71.95 (n)
zebrafish
(Danio rerio)
 Actinopterygii lpar2a 30
  • 56.32 (n)
Species where no ortholog for LPAR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR3 Gene

ENSEMBL:
Gene Tree for LPAR3 (if available)
TreeFam:
Gene Tree for LPAR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPAR3: view image

Paralogs for LPAR3 Gene

Paralogs for LPAR3 Gene

(10) SIMAP similar genes for LPAR3 Gene using alignment to 1 proteins:

  • LPAR3_HUMAN
genes like me logo Genes that share paralogs with LPAR3: view

Variants for LPAR3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPAR3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
717261 Benign: not provided 84,865,779(-) A/C SYNONYMOUS_VARIANT
780244 Benign: not provided 84,814,046(-) C/T MISSENSE_VARIANT
789692 Benign: not provided 84,814,083(-) T/C SYNONYMOUS_VARIANT
rs35745543 - p.Arg231Gln

Additional dbSNP identifiers (rs#s) for LPAR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LPAR3 Gene

Variant ID Type Subtype PubMed ID
esv3586674 CNV loss 21293372
nsv462383 CNV gain 19166990
nsv470724 CNV gain 18288195
nsv476715 CNV novel sequence insertion 20440878
nsv546700 CNV gain 21841781
nsv830448 CNV loss 17160897
nsv947434 CNV duplication 23825009

Variation tolerance for LPAR3 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPAR3 Gene

Human Gene Mutation Database (HGMD)
LPAR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR3 Gene

Disorders for LPAR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LPAR3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
triple-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search LPAR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LPAR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LPAR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPAR3 Gene

Publications for LPAR3 Gene

  1. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. (PMID: 10488122) Bandoh K … Inoue K (The Journal of biological chemistry 1999) 2 3 4 23 54
  2. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PMID: 10727522) Im DS … Lynch KR (Molecular pharmacology 2000) 3 4 23 54
  3. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PMID: 18840781) Grant SF … Hakonarson H (Diabetes 2009) 3 41 54
  4. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. (PMID: 19001604) Yu S … Mills GB (Journal of the National Cancer Institute 2008) 3 23 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

ExternalLinks

View latest publications for LPAR3 gene in Mastermind

Products for LPAR3 Gene

  • Signalway ELISA kits for LPAR3
  • Signalway Proteins for LPAR3

Sources for LPAR3 Gene