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This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
LPAR3 (Lysophosphatidic Acid Receptor 3) is a Protein Coding gene. Diseases associated with LPAR3 include Trachea Adenoid Cystic Carcinoma and Tracheal Cancer. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phospholipid binding. An important paralog of this gene is LPAR1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J084892 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 260.1 | +0.3 | 305 | 1.8 | ZEB1 ZIC2 ZNF610 ZNF623 SIN3A ZNF639 KLF7 ZNF341 ZNF433 KLF9 | LPAR3 HSALNG0004831-001 ZNHIT6 HSALNG0004829 SSX2IP | |
GH01J084894 | Enhancer | 0.3 | Ensembl ENCODE | 259.7 | -1.9 | -1895 | 1.4 | LPAR3 HSALNG0004831-001 HSALNG0004831-002 MCOLN2 | ||
GH01J084891 | Enhancer | 0.2 | Ensembl | 258.4 | +1.5 | 1505 | 0.2 | LPAR3 HSALNG0004829 SSX2IP | ||
GH01J084851 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 16.6 | +39.4 | 39405 | 5.6 | BCL11A ZNF217 BHLHE40 CEBPB ZNF395 IRF4 TRIM22 GABPA CTBP1 FOSL1 | LPAR3 BCL10 GNG5 MCOLN2 C1orf52 HSALNG0004829 SSX2IP | |
GH01J084846 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 15.8 | +44.8 | 44805 | 4 | ZNF217 ZIC2 ZNF610 MBD2 MAX ZNF341 RXRA ZNF843 FOXA2 PRDM6 | LPAR3 MCOLN2 GNG5 BCL10 C1orf52 HSALNG0004829 SSX2IP |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001965 | G-protein alpha-subunit binding | IEA | -- |
GO:0004930 | G protein-coupled receptor activity | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 32296183 |
GO:0005543 | phospholipid binding | IEA | -- |
GO:0008289 | lipid binding | TAS | 10488122 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 10488122 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | Pathways in cancer | ||
5 | Phospholipase D signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | 10488122 |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
farnesyl diphosphate | Experimental | Pharma | Antagonist | 0 | ||
Ki16425 | Pharma | LPA receptor antagonist | 0 | |||
1-Oleoyl lysophosphatidic acid sodium salt | Pharma | Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 | 0 | |||
GRI 977143 | Pharma | LPA2 receptor non-lipid agonist, Selective LPA2 receptor non-lipid agonist | 0 | |||
H2L 5765834 | Pharma | LPA1,3,5 antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
dioctanoy?àëlglycerol?àë pyrophos?àëphate |
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Antagonist |
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LysoPA(0:0/16:0) |
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LysoPA(0:0/18:0) |
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LysoPA(0:0/18:1(9Z)) |
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LysoPA(0:0/18:2(9Z,12Z)) |
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Compound | Action | Cas Number |
---|---|---|
1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of LPA1 and LPA2 | 325465-93-8 |
GRI 977143 | Selective LPA2 receptor non-lipid agonist | 325850-81-5 |
H2L 5765834 | LPA1,3,5 antagonist | 420841-84-5 |
H2L5186303 | Potent and selective LPA2 receptor antagonist | 139262-76-3 |
TC LPA5 4 | LPA5 receptor antagonist | 1393814-38-4 |
Compound | Action | Cas Number |
---|---|---|
1-Oleoyl lysophosphatidic acid sodium salt | Activates LPA receptor | 325465-93-8 |
GRI 977143 | LPA2 receptor non-lipid agonist | 325850-81-5 |
H2L 5765834 | 420841-84-5 | |
H2L5186303 | 139262-76-3 | |
Ki16198 | LPA antagonist | 355025-13-7 |
Ki16425 | LPA receptor antagonist | 355025-24-0 |
TC LPA5 4 | 1393814-38-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LPAR3 30 31 |
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OneToOne | |
Dog (Canis familiaris) |
Mammalia | LPAR3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LPAR3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LPAR3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LPAR3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lpar3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lpar3 30 |
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Chicken (Gallus gallus) |
Aves | LPAR3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LPAR3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lpar3 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | lpar2a 30 |
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SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs41289037 | Benign: not provided | 84,865,779(-) |
A/C NM_012152.3(LPAR3):c.342T>G (p.Thr114=) |
SYNONYMOUS | |
rs58970370 | Benign: not provided | 84,814,046(-) |
C/T NM_012152.3(LPAR3):c.862G>A (p.Val288Met) |
MISSENSE | |
rs61737670 | Benign: not provided | 84,814,083(-) |
T/C NM_012152.3(LPAR3):c.825A>G (p.Lys275=) |
SYNONYMOUS | |
rs35745543 | - |
p.Arg231Gln |
Disorder | Aliases | PubMed IDs |
---|---|---|
trachea adenoid cystic carcinoma |
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tracheal cancer |
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hutchinson-gilford progeria syndrome |
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trachea carcinoma |
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ovarian cancer |
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