Aliases for LPAR2 Gene
External Ids for LPAR2 Gene
Previous HGNC Symbols for LPAR2 Gene
Previous GeneCards Identifiers for LPAR2 Gene
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for LPAR2 Gene
LPAR2 (Lysophosphatidic Acid Receptor 2) is a Protein Coding gene. Diseases associated with LPAR2 include Secretory Diarrhea and Triple-Receptor Negative Breast Cancer. Among its related pathways are Signaling by GPCR and G12-G13 in Cellular Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot Summary for LPAR2 Gene
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.