This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length seq... See more...

Aliases for LPAR2 Gene

Aliases for LPAR2 Gene

  • Lysophosphatidic Acid Receptor 2 2 3 4 5
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 4 2 3
  • Lysophosphatidic Acid Receptor Edg-4 3 4
  • LPA Receptor 2 3 4
  • LPA-2 3 4
  • EDG4 3 4
  • LPA2 3 4
  • Lysophosphatidic Acid Receptor EDG4 3
  • G Protein-Coupled Receptor 3
  • LPA Receptor EDG4 3
  • EDG-4 3

External Ids for LPAR2 Gene

Previous HGNC Symbols for LPAR2 Gene

  • EDG4

Previous GeneCards Identifiers for LPAR2 Gene

  • GC19M019597
  • GC19M019734
  • GC19M019296

Summaries for LPAR2 Gene

Entrez Gene Summary for LPAR2 Gene

  • This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for LPAR2 Gene

LPAR2 (Lysophosphatidic Acid Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot Summary for LPAR2 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

Gene Wiki entry for LPAR2 Gene

Additional gene information for LPAR2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPAR2 Gene

Genomics for LPAR2 Gene

GeneHancer (GH) Regulatory Elements for LPAR2 Gene

Promoters and enhancers for LPAR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J019628 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 759.2 +0.7 663 3 SREBF1 MNT NKRF POLR2A NCOA3 ZNF687 CEBPG IKZF1 CREB1 PRDM10 LPAR2 lnc-GMIP-1 ATP13A1 NR2C2AP UPF1 ZNF90 TMEM161A MAU2 lnc-LPAR2-1 lnc-ZNF101-1
GH19J019605 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 31.4 +22.4 22440 2 HLF MNT CBFA2T2 CREB1 CTBP1 CEBPB JUN JUND MAX ZBTB48 ENSG00000259242 LPAR2 GMIP ATP13A1 GATAD2A PBX4
GH19J019667 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 16.2 -39.9 -39889 3.6 SP1 ZBTB40 MLX RBPJ POLR2A NR2F1 NR2F6 FOS CREB1 HCFC1 ATP13A1 ZNF101 UPF1 NDUFA13 NCAN LPAR2 YJEFN3 CRTC1 CERS1 GDF1
GH19J019641 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 16.4 -14.1 -14142 3.1 CTCF ZBTB6 POLR2A MYC CC2D1A ELF1 RAD21 ZNF121 MNT ZNF148 GMIP LPAR2 TM6SF2 lnc-LPAR2-1 lnc-ZNF101-1
GH19J019661 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 14.6 -34.3 -34343 4.3 ZNF785 SP1 ZBTB40 SIX5 RBPJ POLR2A TCF7L2 CREB1 HCFC1 ZNF362 ATP13A1 UPF1 NDUFA13 MAU2 LPAR2 NR2C2AP ENSG00000267481 TMEM161A ZNF90 SUGP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPAR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LPAR2 gene promoter:
  • IRF-7A
  • Olf-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)

Genomic Locations for LPAR2 Gene

Genomic Locations for LPAR2 Gene
chr19:19,623,655-19,628,930
(GRCh38/hg38)
Size:
5,276 bases
Orientation:
Minus strand
chr19:19,734,464-19,739,739
(GRCh37/hg19)
Size:
5,276 bases
Orientation:
Minus strand

Genomic View for LPAR2 Gene

Genes around LPAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR2 Gene

Proteins for LPAR2 Gene

  • Protein details for LPAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBW0-LPAR2_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 2
    Protein Accession:
    Q9HBW0
    Secondary Accessions:
    • O00543
    • O43431

    Protein attributes for LPAR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    39084 Da
    Quaternary structure:
    • Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2.
    Miscellaneous:
    • PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.
    SequenceCaution:
    • Sequence=AAC27728.1; Type=Frameshift; Positions=348; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LPAR2 Gene

neXtProt entry for LPAR2 Gene

Post-translational modifications for LPAR2 Gene

  • Glycosylation at Asn10 and Asn18
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LPAR2 Gene

Domains & Families for LPAR2 Gene

Gene Families for LPAR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for LPAR2 Gene

GenScript: Design optimal peptide antigens:
  • Lysophosphatidic acid receptor Edg-4 (LPAR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBW0

UniProtKB/Swiss-Prot:

LPAR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR2: view

Function for LPAR2 Gene

Molecular function for LPAR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

Phenotypes From GWAS Catalog for LPAR2 Gene

Gene Ontology (GO) - Molecular Function for LPAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 9525886
GO:0005515 protein binding IPI 14688263
GO:0008289 lipid binding TAS 9525886
GO:0070915 lysophosphatidic acid receptor activity IEA --
genes like me logo Genes that share ontologies with LPAR2: view
genes like me logo Genes that share phenotypes with LPAR2: view

Animal Models for LPAR2 Gene

MGI Knock Outs for LPAR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR2

CRISPR Products

miRNA for LPAR2 Gene

miRTarBase miRNAs that target LPAR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR2

Clone Products

  • Addgene plasmids for LPAR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR2 Gene

Localization for LPAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR2 Gene

Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LPAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9525886
GO:0009986 cell surface IDA,IEA 19306925
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPAR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPAR2 Gene

Pathways & Interactions for LPAR2 Gene

genes like me logo Genes that share pathways with LPAR2: view

Pathways by source for LPAR2 Gene

SIGNOR curated interactions for LPAR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for LPAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
GO:0007202 activation of phospholipase C activity TAS 9804623
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 9804623
genes like me logo Genes that share ontologies with LPAR2: view

Drugs & Compounds for LPAR2 Gene

(20) Drugs for LPAR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist, Agonist 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Ki16425 Pharma Antagonist LPA receptor antagonist 0

(16) Additional Compounds for LPAR2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPA(0:0/16:0)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic Acid(0:0/18:0)
  • Lysophosphatidic Acid(18:0)
  • 2-stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic Acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic Acid(0:0/18:1)
  • 2-oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic Acid(18:2)
LysoPA(16:0/0:0)
  • 1-Hexadecanoyl-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-sn-glycero-3-phosphoric acid
  • 1-Palmitoylglycerol 3-phosphoric acid
  • 1-Palmitoyl-sn-glycerol 3-phosphate
  • PLPA

(5) Tocris Compounds for LPAR2 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(8) ApexBio Compounds for LPAR2 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
GRI 977143 LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
LPA2 antagonist 1 1017606-66-4
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR2: view

Transcripts for LPAR2 Gene

mRNA/cDNA for LPAR2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR2

Clone Products

  • Addgene plasmids for LPAR2

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h · 5i ^ 6
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - - -
SP11: -

Relevant External Links for LPAR2 Gene

GeneLoc Exon Structure for
LPAR2
ECgene alternative splicing isoforms for
LPAR2

Expression for LPAR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPAR2 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR2 Gene

This gene is overexpressed in Whole Blood (x24.6).

Protein differential expression in normal tissues from HIPED for LPAR2 Gene

This gene is overexpressed in Testis (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LPAR2 Gene



Protein tissue co-expression partners for LPAR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LPAR2 Gene:

LPAR2

SOURCE GeneReport for Unigene cluster for LPAR2 Gene:

Hs.122575

mRNA Expression by UniProt/SwissProt for LPAR2 Gene:

Q9HBW0-LPAR2_HUMAN
Tissue specificity: Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.

Evidence on tissue expression from TISSUES for LPAR2 Gene

  • Lung(4.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with LPAR2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR2 Gene

Orthologs for LPAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR2 33 32
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LPAR2 33 32
  • 90.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LPAR2 33 32
  • 88.13 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar2 17 33 32
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Lpar2 32
  • 86.35 (n)
oppossum
(Monodelphis domestica)
Mammalia LPAR2 33
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPAR2 33 32
  • 69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPAR2 33
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar2 32
  • 62.21 (n)
zebrafish
(Danio rerio)
Actinopterygii lpar2b 33 32
  • 64.11 (n)
OneToMany
lpar2a 33
  • 49 (a)
OneToMany
Species where no ortholog for LPAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR2 Gene

ENSEMBL:
Gene Tree for LPAR2 (if available)
TreeFam:
Gene Tree for LPAR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPAR2: view image

Paralogs for LPAR2 Gene

(12) SIMAP similar genes for LPAR2 Gene using alignment to 6 proteins:

  • LPAR2_HUMAN
  • K7EJJ9_HUMAN
  • K7ELJ6_HUMAN
  • K7ENG7_HUMAN
  • K7ER68_HUMAN
  • L8E990_HUMAN
genes like me logo Genes that share paralogs with LPAR2: view

Variants for LPAR2 Gene

Sequence variations from dbSNP and Humsavar for LPAR2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000175239 -- 19,624,909(-) G/A intron_variant
rs1000340066 -- 19,626,370(-) T/C intron_variant
rs1000938780 -- 19,627,699(-) C/T 5_prime_UTR_variant, intron_variant
rs1001159277 -- 19,629,719(-) C/T upstream_transcript_variant
rs1001389523 -- 19,627,949(-) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LPAR2 Gene

Variant ID Type Subtype PubMed ID
nsv1160593 CNV deletion 26073780
nsv509725 CNV insertion 20534489
nsv952427 CNV deletion 24416366

Variation tolerance for LPAR2 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPAR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR2 Gene

Disorders for LPAR2 Gene

Additional Disease Information for LPAR2

No disorders were found for LPAR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAR2 Gene

Publications for LPAR2 Gene

  1. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. (PMID: 9525886) An S … Goetzl EJ (The Journal of biological chemistry 1998) 2 3 4 23 56
  2. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PMID: 19306925) Aziziyeh AI … Bhattacharya M (Cellular signalling 2009) 3 4 23 56
  3. MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PMID: 16904289) Zhang H … Yun CC (Cellular signalling 2007) 3 4 23 56
  4. NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. (PMID: 15143197) Oh YS … Suh PG (Molecular and cellular biology 2004) 3 4 23 56
  5. Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. (PMID: 10922489) Bandoh K … Inoue K (FEBS letters 2000) 3 4 23 56

Products for LPAR2 Gene

Sources for LPAR2 Gene