LPAR1 Gene (Protein Coding)

Lysophosphatidic Acid Receptor 1

GC09M110873
GIFtS:
47
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of n... See more...

Aliases for LPAR1 Gene

Aliases for LPAR1 Gene

  • Lysophosphatidic Acid Receptor 1 2 3 4 5
  • LPA1 2 3 4
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 2 2 3
  • Lysophosphatidic Acid Receptor Edg-2 3 4
  • LPA Receptor 1 3 4
  • Mrec1.3 2 3
  • Rec.1.3 2 3
  • Gpcr26 2 3
  • Edg-2 2 3
  • Vzg-1 2 3
  • LPA-1 3 4
  • EDG2 3 4
  • Ventricular Zone Gene 1 3
  • LPAR1 5
  • VZG1 3

External Ids for LPAR1 Gene

Previous HGNC Symbols for LPAR1 Gene

  • EDG2

Previous GeneCards Identifiers for LPAR1 Gene

  • GC09M112676
  • GC09M113635
  • GC09M083234

Summaries for LPAR1 Gene

Entrez Gene Summary for LPAR1 Gene

  • The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

GeneCards Summary for LPAR1 Gene

LPAR1 (Lysophosphatidic Acid Receptor 1) is a Protein Coding gene. Diseases associated with LPAR1 include Pulmonary Fibrosis and Spinal Stenosis. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phospholipid binding. An important paralog of this gene is LPAR2.

UniProtKB/Swiss-Prot Summary for LPAR1 Gene

  • Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Gene Wiki entry for LPAR1 Gene

Additional gene information for LPAR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPAR1 Gene

Genomics for LPAR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LPAR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J111033 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 255.7 +2.1 2098 7 ZBTB10 CTCF ZIC2 TRIM22 MAFF ZNF341 SMC3 KLF9 SMARCA5 BCL11B LPAR1 HSALNG0073672 SVEP1 PTGR1 RF00017-7811 MUSK
GH09J111021 Promoter/Enhancer 0.9 EPDnew Ensembl 250.4 +16.1 16102 1.8 MAFF ZNF316 NFE2 MAFK MAFG BACH1 IKZF1 IKZF2 RELB EMSY LPAR1 HSALNG0073672 RF00017-7811 MUSK
GH09J110999 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.3 +39.5 39512 0.1 LPAR1 RF00017-7811 HSALNG0073672 MUSK
GH09J111040 Promoter 0.4 EPDnew 250.7 -1.6 -1587 0.1 JUND LPAR1 HSALNG0073672 piR-38051-301 OR2K2
GH09J111160 Enhancer 1.2 VISTA Ensembl ENCODE CraniofacialAtlas 23.7 -124.2 -124175 5.2 NR2C1 MAFK JUND SP7 NANOG MNT CEBPB FOS LPAR1 piR-38352-580 HSALNG0073677 ENSG00000227531 LOC105376219 OR2K2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LPAR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPAR1

Top Transcription factor binding sites by QIAGEN in the LPAR1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LPAR1 Gene

Latest Assembly
chr9:110,873,252-111,038,998
(GRCh38/hg38)
Size:
165,747 bases
Orientation:
Minus strand

Previous Assembly
chr9:113,635,543-113,801,278
(GRCh37/hg19 by Entrez Gene)
Size:
165,736 bases
Orientation:
Minus strand

chr9:113,635,543-113,800,981
(GRCh37/hg19 by Ensembl)
Size:
165,439 bases
Orientation:
Minus strand

Genomic View for LPAR1 Gene

Genes around LPAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LPAR1 Gene

Proteins for LPAR1 Gene

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  • Protein details for LPAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92633-LPAR1_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 1
    Protein Accession:
    Q92633
    Secondary Accessions:
    • B4DK36
    • O00656
    • O00722
    • P78351

    Protein attributes for LPAR1 Gene

    Size:
    364 amino acids
    Molecular mass:
    41109 Da
    Quaternary structure:
    • Interacts with RALA and GRK2 (PubMed:19306925). Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).

    Three dimensional structures from OCA and Proteopedia for LPAR1 Gene

    Alternative splice isoforms for LPAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPAR1 Gene

Protein Expression for LPAR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LPAR1 Gene

Other Protein References for LPAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for LPAR1 Gene

Domains & Families for LPAR1 Gene

Gene Families for LPAR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for LPAR1 Gene

InterPro:
Blocks:
  • Lysophosphatidic acid receptor (EDG2) signature
  • Lysophosphatidic acid receptor family signature
ProtoNet:

Suggested Antigen Peptide Sequences for LPAR1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61127, highly similar to Lysophosphatidic acid receptor Edg-2 (B4DK36_HUMAN)
  • cDNA FLJ55767, highly similar to Lysophosphatidic acid receptor Edg-2 (B4DQ18_HUMAN)
  • Lysophosphatidic acid receptor Edg-2 (LPAR1_HUMAN)
  • cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA (Q5VZX0_HUMAN)
  • cDNA FLJ51746, highly similar to Lysophosphatidic acid receptor Edg-2 (Q6GPG7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92633

UniProtKB/Swiss-Prot:

LPAR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR1: view

Function for LPAR1 Gene

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Molecular function for LPAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Phenotypes From GWAS Catalog for LPAR1 Gene

Gene Ontology (GO) - Molecular Function for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 19306925
GO:0005543 phospholipid binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with LPAR1: view
genes like me logo Genes that share phenotypes with LPAR1: view

Animal Models for LPAR1 Gene

MGI Knock Outs for LPAR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for LPAR1

miRNA for LPAR1 Gene

miRTarBase miRNAs that target LPAR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR1

Clone products for research

  • Addgene plasmids for LPAR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR1 Gene

Localization for LPAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR1 Gene

Cell surface. Cell membrane. Multi-pass membrane protein. Endosome. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000269 PubMed:19306925}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR1 gene
Compartment Confidence
plasma membrane 5
endosome 5
nucleus 3
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005768 endosome IEA,IDA 19306925
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS,ISS --
GO:0009986 cell surface IEA,IDA 19306925
genes like me logo Genes that share ontologies with LPAR1: view

Pathways & Interactions for LPAR1 Gene

genes like me logo Genes that share pathways with LPAR1: view

SIGNOR curated interactions for LPAR1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with LPAR1: view

Drugs & Compounds for LPAR1 Gene

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(25) Drugs for LPAR1 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AM966 Pharma Antagonist LPA1 antagonist, oral active, high affinity, selective, 0
1-Oleoyl lysophosphatidic acid sodium salt Pharma Activates LPA receptor, Endogenous agonist of LPA1 and LPA2 0
GRI 977143 Pharma LPA2 receptor non-lipid agonist, Selective LPA2 receptor non-lipid agonist 0
H2L 5765834 Pharma LPA1,3,5 antagonist 0
H2L5186303 Pharma Potent and selective LPA2 receptor antagonist 0

(17) Additional Compounds for LPAR1 Gene - From: IUPHAR, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?àëlglycerol?àë pyrophos?àëphate
Antagonist
LysoPA(0:0/16:0)
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic acid(0:0/16:0)
  • LPA(16:0)
  • 2-Hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
  • Lysophosphatidic acid(18:0)
  • 2-Stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic acid(0:0/18:1)
  • 2-Oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic acid(18:2)

(5) Tocris Compounds for LPAR1 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(10) ApexBio Compounds for LPAR1 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
AM095 Potent LPA1 receptor antagonist 1345614-59-6
AM-095 free base Potent LPA1 receptor antagonist 1228690-36-5
AM966 LPA1 antagonist, oral active, high affinity, selective, 1228690-19-4
GRI 977143 LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR1: view

Drug products for research

Transcripts for LPAR1 Gene

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mRNA/cDNA for LPAR1 Gene

76 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPAR1

Clone products for research

  • Addgene plasmids for LPAR1

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - - - - - -
SP9: - -

Relevant External Links for LPAR1 Gene

GeneLoc Exon Structure for
LPAR1

Expression for LPAR1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPAR1 Gene

mRNA expression in normal human tissues for LPAR1 Gene
mRNA expression by GTEx for LPAR1 GenemRNA expression by BioGPS for LPAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPAR1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.1), Brain - Putamen (basal ganglia) (x4.1), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for LPAR1 Gene

This gene is overexpressed in Testis (9.1), Skin (8.7), Frontal cortex (8.1), Spinal cord (7.3), and Urinary Bladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAR1 Gene



Protein tissue co-expression partners for LPAR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPAR1

SOURCE GeneReport for Unigene cluster for LPAR1 Gene:

Hs.126667

mRNA Expression by UniProt/SwissProt for LPAR1 Gene:

Q92633-LPAR1_HUMAN
Tissue specificity: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858). Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075). Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258).

Evidence on tissue expression from TISSUES for LPAR1 Gene

  • Nervous system(5)
  • Liver(4.3)
  • Heart(2.4)
  • Muscle(2.3)
  • Intestine(2.3)
  • Lymph node(2.2)
  • Skin(2.2)
  • Lung(2.1)
  • Spleen(2.1)
  • Blood(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with LPAR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR1 Gene

Orthologs for LPAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LPAR1 30 31
  • 100 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia LPAR1 31
  • 95 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LPAR1 30 31
  • 94.05 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia LPAR1 31
  • 94 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LPAR1 30 31
  • 91.67 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Lpar1 30 17 31
  • 90.48 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Lpar1 30
  • 89.56 (n)
Chicken
(Gallus gallus)
 Aves LPAR1 30 31
  • 83.76 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia LPAR1 31
  • 92 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia lpar1 30
  • 77.66 (n)
African clawed frog
(Xenopus laevis)
 Amphibia edg2-A 30
Zebrafish
(Danio rerio)
 Actinopterygii lpar1 30 31
  • 76.49 (n)
 OneToOne
Species where no ortholog for LPAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LPAR1 Gene

ENSEMBL:
Gene Tree for LPAR1 (if available)
TreeFam:
Gene Tree for LPAR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPAR1: view image

Paralogs for LPAR1 Gene

Paralogs for LPAR1 Gene

(16) SIMAP similar genes for LPAR1 Gene using alignment to 5 proteins:

  • LPAR1_HUMAN
  • B1AP63_HUMAN
  • B4DK36_HUMAN
  • B4DQ18_HUMAN
  • Q6GPG7_HUMAN
genes like me logo Genes that share paralogs with LPAR1: view

Variants for LPAR1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPAR1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs41279057 Benign: not provided 110,941,779(-) C/T
NM_001401.5(LPAR1):c.435G>A (p.Glu145=) 		SYNONYMOUS
rs11542862 - p.Asn77Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LPAR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LPAR1 Gene

Variant ID Type Subtype PubMed ID
esv2667259 CNV deletion 23128226
esv2738930 CNV deletion 23290073
esv33480 CNV gain+loss 17666407
esv3445715 CNV insertion 20981092
esv3621475 CNV loss 21293372
esv3621477 CNV gain 21293372
esv3621478 CNV gain 21293372
esv3621479 CNV loss 21293372
nsv526335 CNV gain 19592680
nsv527204 CNV loss 19592680
nsv527998 CNV gain 19592680
nsv831689 CNV gain 17160897

Variation tolerance for LPAR1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPAR1 Gene

Human Gene Mutation Database (HGMD)
LPAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR1 Gene

Disorders for LPAR1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LPAR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pulmonary fibrosis
  • fibrosis of lung
spinal stenosis
  • cervical spinal stenosis
ovarian cancer
  • ovarian cancer, somatic
tooth disease
  • teeth disease
pulmonary fibrosis, idiopathic
  • ipf
- elite association - COSMIC cancer census association via MalaCards
Search LPAR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LPAR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LPAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPAR1 Gene

Publications for LPAR1 Gene

  1. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. (PMID: 9070858) An S … Goetzl EJ (Biochemical and biophysical research communications 1997) 2 3 4 23
  2. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PMID: 19306925) Aziziyeh AI … Bhattacharya M (Cellular signalling 2009) 3 4 23
  3. Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections. (PMID: 18625619) Dieguez-Gonzalez R … Gonzalez A (Annals of the rheumatic diseases 2009) 3 23 41
  4. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. (PMID: 8922387) Hecht JH … Chun J (The Journal of cell biology 1996) 2 3 23
  5. Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. (PMID: 26091040) Chrencik JE … Hanson MA (Cell 2015) 3 4

ExternalLinks

View latest publications for LPAR1 gene in Mastermind

Products for LPAR1 Gene

  • Addgene plasmids for LPAR1

Sources for LPAR1 Gene