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Aliases for LPAL2 Gene

Aliases for LPAL2 Gene

  • Lipoprotein(A) Like 2, Pseudogene 2 3 5
  • Lipoprotein, Lp(A)-Like 2, Pseudogene 2 3
  • Apo(A)Rg-C 3 4
  • APOARGC 3 4
  • Apolipoprotein A-Related Gene C Protein 4
  • Apolipoprotein (A) Related Gene C 3
  • Lipoprotein, Lp(A)-Like 2 2
  • Apolipoprotein A-Like 2
  • Apo(A)-Like Protein 2 4
  • Lp(A)-Liker Protein 2 4
  • Apolipoprotein A-II 3
  • EC 56
  • EC 3.4.21 56
  • APOA2 3
  • APOAL 3

External Ids for LPAL2 Gene

Previous HGNC Symbols for LPAL2 Gene


Previous GeneCards Identifiers for LPAL2 Gene

  • GC06U990076
  • GC06M160721
  • GC06M160783
  • GC06M160858
  • GC06M160793
  • GC06M160807
  • GC06M160887
  • GC06M158362

Summaries for LPAL2 Gene

Entrez Gene Summary for LPAL2 Gene

  • Apolipoprotein(a) is the distinguishing protein moiety of lipoprotein(a), of which elevated plasma levels are correlated with an increased risk of atherosclerosis. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Consequently, this gene is considered to be a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for LPAL2 Gene

LPAL2 (Lipoprotein(A) Like 2, Pseudogene) is a Pseudogene.

Additional gene information for LPAL2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAL2 Gene

Genomics for LPAL2 Gene

GeneHancer (GH) Regulatory Elements for LPAL2 Gene

Promoters and enhancers for LPAL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I160519 Enhancer 1.2 Ensembl ENCODE 557.1 -0.1 -51 1.8 ATF1 ARNT SIN3A ZNF2 ZNF48 YY1 ZNF766 ARID2 ZNF143 ATF7 LPAL2 WTAP LOC729603 MAP3K4 LPA
GH06I160160 Enhancer 0.7 ENCODE 5.2 +359.7 359695 0.2 ELF3 CTCF LEF1 FOXA2 CEBPG RAD21 RARA GATAD2A TFE3 NFIA LPAL2 ENSG00000216516 SLC22A1
GH06I160534 Enhancer 0.9 Ensembl ENCODE 0.4 -14.0 -13961 0.5 ELF3 CTCF ARID4B ZNF2 DNMT3B ZNF48 RAD21 SCRT2 SMC3 ZNF143 LPAL2 LPA
GH06I160455 Enhancer 1 Ensembl ENCODE 0.2 +64.4 64432 1.7 ELF3 RB1 ARID4B ZNF48 ZSCAN9 RAD21 ARID2 SCRT2 ZNF143 RUNX3 SLC22A3 SNORA29 TCP1 PIR50129 LPAL2
GH06I160461 Enhancer 0.9 Ensembl ENCODE 0.2 +58.0 58011 2.3 GTF2E2 EBF1 BATF IRF4 FOSL1 ZNF316 POLR2A NFATC1 ATF7 ETV6 SLC22A3 PIR50129 LPAL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LPAL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LPAL2 gene promoter:

Genomic Locations for LPAL2 Gene

Genomic Locations for LPAL2 Gene
66,842 bases
Minus strand

Genomic View for LPAL2 Gene

Genes around LPAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAL2 Gene

Proteins for LPAL2 Gene

  • Protein details for LPAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative apolipoprotein(a)-like protein 2
    Protein Accession:
    Secondary Accessions:
    • E1P5B4

    Protein attributes for LPAL2 Gene

    132 amino acids
    Molecular mass:
    14886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAL2 Gene

Selected DME Specific Peptides for LPAL2 Gene


Post-translational modifications for LPAL2 Gene

Domains & Families for LPAL2 Gene

Protein Domains for LPAL2 Gene


Suggested Antigen Peptide Sequences for LPAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.
  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.
genes like me logo Genes that share domains with LPAL2: view

No data available for Gene Families for LPAL2 Gene

Function for LPAL2 Gene

Molecular function for LPAL2 Gene

GENATLAS Biochemistry:
lypoprotein Lp(a)-like 2

Enzyme Numbers (IUBMB) for LPAL2 Gene

Phenotypes From GWAS Catalog for LPAL2 Gene

Gene Ontology (GO) - Molecular Function for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LPAL2: view
genes like me logo Genes that share phenotypes with LPAL2: view

miRNA for LPAL2 Gene

miRTarBase miRNAs that target LPAL2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPAL2 Gene

Localization for LPAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAL2 Gene


Gene Ontology (GO) - Cellular Components for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LPAL2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for LPAL2 Gene

Pathways & Interactions for LPAL2 Gene

SuperPathways for LPAL2 Gene

No Data Available

Interacting Proteins for LPAL2 Gene

Selected Interacting proteins: Q16609-LPAL2_HUMAN for LPAL2 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPAL2: view

No data available for Pathways by source and SIGNOR curated interactions for LPAL2 Gene

Drugs & Compounds for LPAL2 Gene

(1) Additional Compounds for LPAL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LPAL2: view

Transcripts for LPAL2 Gene

mRNA/cDNA for LPAL2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPAL2 Gene

Lipoprotein, Lp(a)-like 2, pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAL2 Gene

No ASD Table

Relevant External Links for LPAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LPAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPAL2 Gene

mRNA differential expression in normal tissues according to GTEx for LPAL2 Gene

This gene is overexpressed in Liver (x24.2).

Protein differential expression in normal tissues from HIPED for LPAL2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAL2 Gene

Protein tissue co-expression partners for LPAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LPAL2 Gene:


SOURCE GeneReport for Unigene cluster for LPAL2 Gene:


mRNA Expression by UniProt/SwissProt for LPAL2 Gene:

Tissue specificity: Expressed in liver but not in other tissues tested.
genes like me logo Genes that share expression patterns with LPAL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAL2 Gene

Orthologs for LPAL2 Gene

Evolution for LPAL2 Gene

Gene Tree for LPAL2 (if available)
Gene Tree for LPAL2 (if available)

No data available for Orthologs for LPAL2 Gene

Paralogs for LPAL2 Gene

(14) SIMAP similar genes for LPAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAL2: view

No data available for Paralogs for LPAL2 Gene

Variants for LPAL2 Gene

Sequence variations from dbSNP and Humsavar for LPAL2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000092862 -- 160,468,150(-) C/T intron_variant
rs1000137036 -- 160,488,911(-) A/T intron_variant
rs1000279431 -- 160,501,541(-) T/A intron_variant
rs1000404172 -- 160,503,688(-) C/T intron_variant
rs1000457755 -- 160,483,033(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LPAL2 Gene

Variant ID Type Subtype PubMed ID
esv1960835 CNV deletion 18987734
esv2663488 CNV deletion 23128226
esv2733055 CNV deletion 23290073
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
esv3611436 CNV gain 21293372
esv3611437 CNV loss 21293372
esv3611438 CNV gain 21293372
esv5050 OTHER sequence alteration 18987735
esv6519 CNV loss 19470904
esv8214 CNV loss 19470904
nsv1026543 CNV gain 25217958
nsv349217 CNV insertion 16902084
nsv525990 CNV loss 19592680
nsv5566 CNV insertion 18451855
nsv818463 CNV gain 17921354
nsv965781 CNV duplication 23825009
nsv969463 CNV duplication 23825009
nsv970183 CNV duplication 23825009
nsv970184 CNV duplication 23825009
nsv970185 CNV duplication 23825009
nsv970186 CNV duplication 23825009

Additional Variant Information for LPAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LPAL2 Gene

Disorders for LPAL2 Gene

Additional Disease Information for LPAL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LPAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAL2 Gene

Publications for LPAL2 Gene

  1. Loss of a splice donor site at a 'skipped exon' in a gene homologous to apolipoprotein(a) leads to an mRNA encoding a protein consisting of a single kringle domain. (PMID: 7749817) Byrne CD … Lawn RM (Arteriosclerosis, thrombosis, and vascular biology 1995) 2 3 4 58
  2. Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes. (PMID: 21900290) Qi Q … Qi L (European heart journal 2012) 3 44 58
  3. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. (PMID: 19198611) Trégouët DA … Samani NJ (Nature genetics 2009) 3 44 58
  4. 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family. (PMID: 7679504) Wade DP … Lawn RM (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 58
  5. Functional Variant in the SLC22A3-LPAL2-LPA Gene Cluster Contributes to the Severity of Coronary Artery Disease. (PMID: 27417586) Wang L … Zhou L (Arteriosclerosis, thrombosis, and vascular biology 2016) 3 58

Products for LPAL2 Gene

Sources for LPAL2 Gene

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