Aliases for LOXL4 Gene
External Ids for LOXL4 Gene
Previous GeneCards Identifiers for LOXL4 Gene
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
GeneCards Summary for LOXL4 Gene
LOXL4 (Lysyl Oxidase Like 4) is a Protein Coding gene. Diseases associated with LOXL4 include Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include copper ion binding and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. An important paralog of this gene is LOXL3.
UniProtKB/Swiss-Prot for LOXL4 Gene
May modulate the formation of a collagenous extracellular matrix.