Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LOXL2 Gene

Aliases for LOXL2 Gene

  • Lysyl Oxidase Like 2 2 3 5
  • Lysyl Oxidase-Related Protein WS9-14 3 4
  • Lysyl Oxidase-Related Protein 2 3 4
  • Lysyl Oxidase-Like Protein 2 3 4
  • Lysyl Oxidase-Like 2 Delta E13 3
  • Lysyl Oxidase-Like 2 Protein 3
  • Lysyl Oxidase Homolog 2 3
  • Lysyl Oxidase Related 2 3
  • Lysyl Oxidase-Like 2 2
  • EC 1.4.3.13 4
  • WS9-14 3
  • LOR2 3
  • LOR 3

External Ids for LOXL2 Gene

Previous GeneCards Identifiers for LOXL2 Gene

  • GC08U990046
  • GC08M023508
  • GC08M022974
  • GC08M023176
  • GC08M023210
  • GC08M021700
  • GC08M023154

Summaries for LOXL2 Gene

Entrez Gene Summary for LOXL2 Gene

  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LOXL2 Gene

LOXL2 (Lysyl Oxidase Like 2) is a Protein Coding gene. Diseases associated with LOXL2 include Hyperostosis Cranialis Interna and Lung Squamous Cell Carcinoma. Among its related pathways are Collagen chain trimerization and Elastic fibre formation. Gene Ontology (GO) annotations related to this gene include chromatin binding and electron transfer activity. An important paralog of this gene is LOXL3.

UniProtKB/Swiss-Prot for LOXL2 Gene

  • Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on Lys-9 (H3K9me3) or Lys-27 (H3K27me3) or when Lys-4 is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:27735137, PubMed:24414204). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555). Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity).

Gene Wiki entry for LOXL2 Gene

Additional gene information for LOXL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOXL2 Gene

Genomics for LOXL2 Gene

GeneHancer (GH) Regulatory Elements for LOXL2 Gene

Promoters and enhancers for LOXL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J023402 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 658 +21.7 21668 2.7 SIN3A ZNF335 GLIS2 EGR1 RCOR1 EGR2 SP3 ZNF398 ZNF148 SP1 LOXL2 R3HCC1 ENTPD4 CHMP7 PIR45078
GH08J023425 Promoter 0.7 EPDnew 650.7 0.0 -12 0.1 POLR2A RELA LOXL2 PIR51990 GC08P023434 ENTPD4
GH08J022692 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.8 +730.7 730745 3.6 HDGF ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 E2F8 EGR3 LOC105379322 LOC105379321 ENSG00000253200 FAM160B2 ENSG00000245025 BMP1 C8orf58 LOXL2 CCAR2
GH08J023342 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 32.5 +80.0 80028 5 PKNOX1 ATF1 ARNT SIN3A GTF3C2 TCF12 ATF7 FOS DEK MCM3 LOXL2 ENSG00000253200 C8orf58 BIN3 ENSG00000245025 SORBS3 CCAR2 ENTPD4 LOC100507156 PIR45078
GH08J023527 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -105.3 -105334 6.5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 FOS SLC25A37 ENSG00000253200 ENTPD4 TNFRSF10C ENSG00000245025 C8orf58 LOXL2 BIN3 TNFRSF10B GC08M023551
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LOXL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LOXL2 gene promoter:

Genomic Locations for LOXL2 Gene

Genomic Locations for LOXL2 Gene
chr8:23,296,897-23,425,328
(GRCh38/hg38)
Size:
128,432 bases
Orientation:
Minus strand
chr8:23,154,410-23,282,841
(GRCh37/hg19)

Genomic View for LOXL2 Gene

Genes around LOXL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOXL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOXL2 Gene

Proteins for LOXL2 Gene

  • Protein details for LOXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4K0-LOXL2_HUMAN
    Recommended name:
    Lysyl oxidase homolog 2
    Protein Accession:
    Q9Y4K0
    Secondary Accessions:
    • B2R5Q0
    • Q53HV3
    • Q9BW70
    • Q9Y5Y8

    Protein attributes for LOXL2 Gene

    Size:
    774 amino acids
    Molecular mass:
    86725 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489;
    Quaternary structure:
    • Component of some chromatin repressor complex. Interacts with SNAI1 (PubMed:16096638). Interacts with TAF10 (PubMed:25959397). Interacts with HSPA5 (PubMed:28332555).
    Miscellaneous:
    • Its overexpression in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that LOXL2 might play a role in tumor progression: expression is correlated with metastasis and decreased survival in patients with aggressive breast cancer (PubMed:21233336, PubMed:21732535). Allosteric inhibition by AB0023 inhibits formation of the tumor microenvironment and reduces metastatic tumor burden in xenograft models (PubMed:20818376, PubMed:21732535). However, inhibiting the enzyme activity of LOXL2 may not be sufficient, since inhibition of keratinocyte differentiation is not prevented in mutants that lack enzyme activity nor by inhibition of activity by the AB0023 antibody, thereby promoting development of squamous cell carcinomas (PubMed:22157764).
    SequenceCaution:
    • Sequence=AAD34343.1; Type=Erroneous termination; Positions=775; Note=Translated as stop.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LOXL2 Gene

neXtProt entry for LOXL2 Gene

Post-translational modifications for LOXL2 Gene

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
  • N-glycosylated. N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core.
  • Glycosylation at posLast=644644, isoforms=455, and isoforms=288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LOXL2 Gene

Domains & Families for LOXL2 Gene

Gene Families for LOXL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LOXL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4K0

UniProtKB/Swiss-Prot:

LOXL2_HUMAN :
  • The fourth SRCR domain plays a important role in optimizing the catalytic activity of the lysyl-oxidase like (LOX) catalytic domain.
  • Belongs to the lysyl oxidase family.
Domain:
  • The fourth SRCR domain plays a important role in optimizing the catalytic activity of the lysyl-oxidase like (LOX) catalytic domain.
Family:
  • Belongs to the lysyl oxidase family.
genes like me logo Genes that share domains with LOXL2: view

Function for LOXL2 Gene

Molecular function for LOXL2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on Lys-9 (H3K9me3) or Lys-27 (H3K27me3) or when Lys-4 is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:27735137, PubMed:24414204). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555). Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-L-lysine + O(2) + H(2)O = [protein]-(S)-2-amino-6-oxohexanoate + NH(3) + H(2)O(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
According to some reports, it is inhibited by beta-aminopropionitrile (BAPN) (PubMed:20439985 and PubMed:23319596). According to another report, it is not inhibited by beta-aminopropionitrile (BAPN) (PubMed:20306300). Specifically inhibited by a mouse monoclonal antibody AB0023, inhibition occurs in a non-competitive manner.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.01 mM for 1,5-diaminopentane {ECO:0000269 PubMed:20439985, ECO:0000269 PubMed:23319596}; KM=1.05 mM for spermine {ECO:0000269 PubMed:20439985, ECO:0000269 PubMed:23319596}; KM=0.59 uM for tropoelastin (without the first three SRCR domains) {ECO:0000269 PubMed:20439985, ECO:0000269 PubMed:23319596}; KM=0.62 uM for tropoelastin (without all four SRCR domains) {ECO:0000269 PubMed:20439985, ECO:0000269 PubMed:23319596}; Note=kcat is 2.04 min(-1) with tropoelastin as substrate (without the first three SRCR domains). kcat is 0.62 min(-1) with tropoelastin as substrate (without all four SRCR domains).;
UniProtKB/Swiss-Prot Induction:
Strongly induced in hypoxia. Direct transcriptional target of HIF1A.
GENATLAS Biochemistry:
lysyl oxidase-like 2,extracellular matrix enzyme,widely expressed predominantly in reproductive tissues (placenta,uterus,prostate)

Enzyme Numbers (IUBMB) for LOXL2 Gene

Phenotypes From GWAS Catalog for LOXL2 Gene

Gene Ontology (GO) - Molecular Function for LOXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004720 protein-lysine 6-oxidase activity IEA,IDA 23319596
GO:0005044 scavenger receptor activity IEA --
GO:0005507 copper ion binding IEA --
GO:0005515 protein binding IPI 16096638
GO:0009055 electron transfer activity TAS 9079631
genes like me logo Genes that share ontologies with LOXL2: view
genes like me logo Genes that share phenotypes with LOXL2: view

Animal Models for LOXL2 Gene

MGI Knock Outs for LOXL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LOXL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LOXL2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LOXL2 Gene

Localization for LOXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LOXL2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus. Chromosome. Endoplasmic reticulum. Note=Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618). {ECO:0000269 PubMed:22204712, ECO:0000269 PubMed:23319596, ECO:0000269 PubMed:24414204, ECO:0000269 PubMed:27735137}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LOXL2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LOXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 27735137
GO:0005576 extracellular region IEA --
GO:0005604 basement membrane ISS --
GO:0005615 extracellular space IDA,IEA 23319596
GO:0005634 nucleus TAS 16096638
genes like me logo Genes that share ontologies with LOXL2: view

Pathways & Interactions for LOXL2 Gene

genes like me logo Genes that share pathways with LOXL2: view

Gene Ontology (GO) - Biological Process for LOXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 25959397
GO:0001666 response to hypoxia IEA,ISS --
GO:0001837 epithelial to mesenchymal transition IDA 16096638
GO:0001935 endothelial cell proliferation IMP 21835952
GO:0002040 sprouting angiogenesis IMP 21835952
genes like me logo Genes that share ontologies with LOXL2: view

No data available for SIGNOR curated interactions for LOXL2 Gene

Drugs & Compounds for LOXL2 Gene

(10) Drugs for LOXL2 Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 202
Ammonia Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for LOXL2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Docosanoyl-CoA
  • Behenoyl-CoA
  • Behenoyl-coenzyme A
genes like me logo Genes that share compounds with LOXL2: view

Transcripts for LOXL2 Gene

mRNA/cDNA for LOXL2 Gene

Unigene Clusters for LOXL2 Gene

Lysyl oxidase-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LOXL2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LOXL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for LOXL2 Gene

GeneLoc Exon Structure for
LOXL2
ECgene alternative splicing isoforms for
LOXL2

Expression for LOXL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LOXL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LOXL2 Gene

This gene is overexpressed in Amniocyte (62.0) and Bone marrow mesenchymal stem cell (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LOXL2 Gene



Protein tissue co-expression partners for LOXL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LOXL2 Gene:

LOXL2

SOURCE GeneReport for Unigene cluster for LOXL2 Gene:

Hs.626637

mRNA Expression by UniProt/SwissProt for LOXL2 Gene:

Q9Y4K0-LOXL2_HUMAN
Tissue specificity: Expressed in many tissues (PubMed:10212285). Highest expression in reproductive tissues, placenta, uterus and prostate (PubMed:10212285). In esophageal epithelium, expressed in the basal, prickle and granular cell layers (PubMed:22204712). Up-regulated in a number of cancers cells and tissues.

Evidence on tissue expression from TISSUES for LOXL2 Gene

  • Kidney(4.6)
  • Spleen(4.1)
  • Lung(3.8)
  • Nervous system(2.9)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with LOXL2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOXL2 Gene

Orthologs for LOXL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOXL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOXL2 34 33
  • 90.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOXL2 34 33
  • 89.75 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Loxl2 33
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Loxl2 16 34 33
  • 84.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LOXL2 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LOXL2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOXL2 34 33
  • 77.35 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LOXL2 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia loxl2 33
  • 70.72 (n)
Str.11918 33
zebrafish
(Danio rerio)
Actinopterygii loxl2b 34 33
  • 70.2 (n)
OneToMany
LOXL2 (3 of 3) 34
  • 70 (a)
OneToMany
loxl2a 34
  • 68 (a)
OneToMany
Dr.715 33
African malaria mosquito
(Anopheles gambiae)
Insecta SCRAL1 33
  • 54.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta lox2 35 33
  • 54.22 (n)
lox 35
  • 42 (a)
Species where no ortholog for LOXL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LOXL2 Gene

ENSEMBL:
Gene Tree for LOXL2 (if available)
TreeFam:
Gene Tree for LOXL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LOXL2: view image

Paralogs for LOXL2 Gene

Paralogs for LOXL2 Gene

(9) SIMAP similar genes for LOXL2 Gene using alignment to 9 proteins:

  • LOXL2_HUMAN
  • E5RFE2_HUMAN
  • E5RFY0_HUMAN
  • E5RHH3_HUMAN
  • E5RI22_HUMAN
  • E5RJL2_HUMAN
  • H0YAP6_HUMAN
  • H0YAR1_HUMAN
  • R4GMS2_HUMAN
genes like me logo Genes that share paralogs with LOXL2: view

Variants for LOXL2 Gene

Sequence variations from dbSNP and Humsavar for LOXL2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000009643 -- 23,336,503(-) G/A intron_variant
rs1000017326 -- 23,385,863(-) C/T intron_variant
rs1000035305 -- 23,360,027(-) A/C intron_variant
rs1000067007 -- 23,373,052(-) A/C intron_variant
rs1000069650 -- 23,342,664(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LOXL2 Gene

Variant ID Type Subtype PubMed ID
dgv7139n100 CNV loss 25217958
dgv7140n100 CNV gain 25217958
esv25599 CNV loss 19812545
nsv1017570 CNV gain 25217958
nsv1026345 CNV gain 25217958
nsv1117811 CNV deletion 24896259
nsv1134912 CNV tandem duplication 24896259
nsv470206 CNV gain 18288195
nsv472520 CNV novel sequence insertion 20440878
nsv610778 CNV loss 21841781
nsv610779 CNV gain 21841781
nsv6118 CNV insertion 18451855
nsv831268 CNV gain 17160897

Variation tolerance for LOXL2 Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LOXL2 Gene

Human Gene Mutation Database (HGMD)
LOXL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LOXL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LOXL2 Gene

Disorders for LOXL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LOXL2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hyperostosis cranialis interna
  • hcin
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search LOXL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LOXL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LOXL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LOXL2 Gene

Publications for LOXL2 Gene

  1. The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. (PMID: 20026874) Schietke R … Wiesener MS (The Journal of biological chemistry 2010) 3 4 22 58
  2. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PMID: 17287949) Akagawa H … Inoue I (Human genetics 2007) 3 22 44 58
  3. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. (PMID: 16096638) Peinado H … Portillo F (The EMBO journal 2005) 3 4 22 58
  4. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. (PMID: 10212285) Jourdan-Le Saux C … Csiszar K (The Journal of biological chemistry 1999) 3 4 22 58
  5. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. (PMID: 9722957) Jourdan-Le Saux C … Csiszar K (Genomics 1998) 2 3 22 58

Products for LOXL2 Gene

Sources for LOXL2 Gene

Content
Loading form....