External Ids for LOX Gene
Previous GeneCards Identifiers for LOX Gene
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
GeneCards Summary for LOX Gene
LOX (Lysyl Oxidase) is a Protein Coding gene. Diseases associated with LOX include Aortic Aneurysm, Familial Thoracic 10 and Familial Thoracic Aortic Aneurysm And Dissection. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. Gene Ontology (GO) annotations related to this gene include copper ion binding and protein-lysine 6-oxidase activity. An important paralog of this gene is LOXL1.
UniProtKB/Swiss-Prot Summary for LOX Gene
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).