Aliases for LONRF2 Gene

Aliases for LONRF2 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 2 2 3 5
  • RNF192 2 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 2 3 4
  • Neuroblastoma Apoptosis-Related Protease 3 4
  • RING Finger Protein 192 3 4
  • FLJ45273 2
  • LONRF2 5

External Ids for LONRF2 Gene

Previous GeneCards Identifiers for LONRF2 Gene

  • GC02M100359
  • GC02M100256
  • GC02M100889
  • GC02M094654

Summaries for LONRF2 Gene

GeneCards Summary for LONRF2 Gene

LONRF2 (LON Peptidase N-Terminal Domain And Ring Finger 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF3.

Additional gene information for LONRF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LONRF2 Gene

Genomics for LONRF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LONRF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J100320 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 615.2 +0.9 900 2.8 CREB1 CTCF PRDM10 ZNF629 TARDBP ZIC2 POLR2A PATZ1 EZH2 ZNF341 LONRF2 CHST10 lnc-CHST10-2 AFF3
GH02J100283 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +33.7 33652 11.7 CEBPG CREB1 GATAD2A HNRNPL PRDM10 ZNF629 ZNF512 RFX1 LEF1 IKZF1 LONRF2 REV1 ENSG00000273306 CHST10 lnc-CHST10-2 AFF3
GH02J100366 Enhancer 0.9 Ensembl ENCODE 34.2 -43.0 -43000 1.4 PRDM10 ZNF140 CEBPB FOS OSR2 JUND ZBTB11 NFIC EP300 WT1 LONRF2 REV1 ENSG00000273306 CHST10 ENSG00000230393 piR-50968-065 CYCSP7
GH02J100416 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 14.8 -94.5 -94500 3.2 ARHGAP35 ZNF512 IKZF1 BACH1 LARP7 PRDM1 MTA2 ZNF143 RBFOX2 POLR2A CHST10 lnc-LONRF2-1 LONRF2 ENSG00000270699
GH02J100281 Enhancer 1 Ensembl ENCODE dbSUPER 18.5 +40.4 40400 1.8 SCRT2 EGR1 CTBP1 ESR1 NFIC ZFHX2 STAT5A NR2F1 NR2F6 DPF2 lnc-CHST10-2 LONRF2 AFF3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LONRF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LONRF2

Top Transcription factor binding sites by QIAGEN in the LONRF2 gene promoter:
  • AhR
  • AREB6
  • En-1
  • FOXL1
  • NF-E2
  • NF-E2 p45
  • p53
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LONRF2 Gene

Genomic Locations for LONRF2 Gene
chr2:100,271,875-100,322,501
(GRCh38/hg38)
Size:
50,627 bases
Orientation:
Minus strand
chr2:100,889,753-100,939,195
(GRCh37/hg19)
Size:
49,443 bases
Orientation:
Minus strand

Genomic View for LONRF2 Gene

Genes around LONRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF2 Gene

Proteins for LONRF2 Gene

  • Protein details for LONRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1L5Z9-LONF2_HUMAN
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 2
    Protein Accession:
    Q1L5Z9
    Secondary Accessions:
    • B9A006
    • Q6ZSR4

    Protein attributes for LONRF2 Gene

    Size:
    754 amino acids
    Molecular mass:
    83654 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LONRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LONRF2 Gene

Post-translational modifications for LONRF2 Gene

  • Ubiquitination at Lys489
  • Modification sites at PhosphoSitePlus

Other Protein References for LONRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LONRF2 Gene

Domains & Families for LONRF2 Gene

Gene Families for LONRF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LONRF2 Gene

GenScript: Design optimal peptide antigens:
  • LONRF2 protein (B7ZKY9_HUMAN)
  • RING finger protein 192 (LONF2_HUMAN)
genes like me logo Genes that share domains with LONRF2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LONRF2 Gene

Function for LONRF2 Gene

Phenotypes From GWAS Catalog for LONRF2 Gene

Gene Ontology (GO) - Molecular Function for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LONRF2: view
genes like me logo Genes that share phenotypes with LONRF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LONRF2

CRISPR Products

miRNA for LONRF2 Gene

miRTarBase miRNAs that target LONRF2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LONRF2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF2 Gene

Localization for LONRF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LONRF2 Gene

Pathways & Interactions for LONRF2 Gene

PathCards logo

SuperPathways for LONRF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LONRF2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LONRF2 Gene

Drugs & Compounds for LONRF2 Gene

No Compound Related Data Available

Transcripts for LONRF2 Gene

mRNA/cDNA for LONRF2 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LONRF2

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF2 Gene

No ASD Table

Relevant External Links for LONRF2 Gene

GeneLoc Exon Structure for
LONRF2

Expression for LONRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LONRF2 Gene

mRNA differential expression in normal tissues according to GTEx for LONRF2 Gene

This gene is overexpressed in Fallopian Tube (x4.6).

Protein differential expression in normal tissues from HIPED for LONRF2 Gene

This gene is overexpressed in Islet of Langerhans (26.4), Heart (16.0), Platelet (10.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LONRF2 Gene



Protein tissue co-expression partners for LONRF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LONRF2

SOURCE GeneReport for Unigene cluster for LONRF2 Gene:

Hs.21380

Evidence on tissue expression from TISSUES for LONRF2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with LONRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LONRF2 Gene

Orthologs for LONRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LONRF2 30 31
  • 99.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LONRF2 30 31
  • 85.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lonrf2 30
  • 80.19 (n)
Mouse
(Mus musculus)
Mammalia Lonrf2 30 17 31
  • 79.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LONRF2 30 31
  • 79.37 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LONRF2 31
  • 57 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LONRF2 31
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LONRF2 30 31
  • 69.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LONRF2 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lonrf2 30
  • 59.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch1073-440b2.1 30
  • 58.28 (n)
LONRF2 31
  • 51 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG32369 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 16 (a)
OneToMany
Species where no ortholog for LONRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LONRF2 Gene

ENSEMBL:
Gene Tree for LONRF2 (if available)
TreeFam:
Gene Tree for LONRF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LONRF2: view image

Paralogs for LONRF2 Gene

Paralogs for LONRF2 Gene

(3) SIMAP similar genes for LONRF2 Gene using alignment to 3 proteins:

  • LONF2_HUMAN
  • B7ZKY9_HUMAN
  • L8E9U6_HUMAN
genes like me logo Genes that share paralogs with LONRF2: view

Variants for LONRF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LONRF2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
711331 Benign: not provided 100,295,518(-) C/T SYNONYMOUS_VARIANT
rs4851287 -. - p.Leu183Prop.Leu426Pro
rs773205136 A colorectal cancer sample p.Arg562Trp

Additional dbSNP identifiers (rs#s) for LONRF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LONRF2 Gene

Variant ID Type Subtype PubMed ID
dgv1157e212 CNV loss 25503493
dgv609e201 CNV deletion 23290073
esv2053654 CNV deletion 18987734
esv2675961 CNV deletion 23128226
esv2720436 CNV deletion 23290073
esv3583986 CNV loss 25503493
esv3591751 CNV loss 21293372
esv3591752 CNV loss 21293372
esv7741 CNV gain 19470904
nsv1072959 CNV deletion 25765185
nsv1123362 CNV deletion 24896259
nsv1136389 CNV deletion 24896259
nsv582531 CNV gain 21841781
nsv834311 CNV gain+loss 17160897
nsv953495 CNV deletion 24416366

Variation tolerance for LONRF2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.09; 92.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LONRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LONRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF2 Gene

Disorders for LONRF2 Gene

Additional Disease Information for LONRF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for LONRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LONRF2 Gene

Publications for LONRF2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for LONRF2 Gene

Sources for LONRF2 Gene