Aliases for LONRF1 Gene

Aliases for LONRF1 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 1 2 3 5
  • RNF191 2 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 1 3 4
  • RING Finger Protein 191 3 4
  • FLJ23749 2
  • LONRF1 5

External Ids for LONRF1 Gene

Previous GeneCards Identifiers for LONRF1 Gene

  • GC08M012624
  • GC08M011121
  • GC08M012579

Summaries for LONRF1 Gene

GeneCards Summary for LONRF1 Gene

LONRF1 (LON Peptidase N-Terminal Domain And Ring Finger 1) is a Protein Coding gene. Diseases associated with LONRF1 include Penile Benign Neoplasm. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LONRF1 Gene

Genomics for LONRF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LONRF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J012752 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 252 +0.5 519 6.6 SP1 ZNF600 MYC IKZF1 SSRP1 JUND ZNF580 ATF2 KLF9 POLR2A LONRF1 HSALNG0063513 lnc-LONRF1-3 RPS3AP34 ENSG00000255122 ENSG00000255556 HSALNG0063512 FAM86B2
GH08J012811 Promoter 0.4 EPDnew 250.2 -55.5 -55478 0.1 ZNF140 LOC340357 LONRF1 RPS3AP34 ENSG00000255122 piR-33422-418 LINC00681 lnc-LONRF1-7 TRMT9B
GH08J012743 Promoter 0.3 EPDnew 250.4 +12.8 12806 0.1 LONRF1 HSALNG0063512 lnc-FAM86B2-7 lnc-LONRF1-3 FAM86B2
GH08J012795 Promoter/Enhancer 1.1 EPDnew FANTOM5 Ensembl 17.7 -38.7 -38728 2.8 CEBPA CEBPB ELF3 CEBPG NFIL3 HLF PKNOX1 SMC3 SP1 LINC00681 LONRF1 LOC340357 ENSG00000255556 piR-47162-165 TRMT9B
GH08J012725 Enhancer 1 Ensembl ENCODE 16.6 +29.4 29373 2.6 JUND CEBPA CEBPB EP300 FOXA2 MAFF SAP130 ZNF316 TEAD3 TCF7L2 MIR3926-1 MIR3926-2 lnc-FAM86B2-6 microRNAhsa-miR-3926-2-3p LONRF1 FAM86B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LONRF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LONRF1

Top Transcription factor binding sites by QIAGEN in the LONRF1 gene promoter:
  • ATF-2
  • c-Jun
  • Cdc5
  • Evi-1
  • Hlf
  • HNF-3beta
  • LCR-F1
  • MZF-1
  • p300
  • Pax-5

Genomic Locations for LONRF1 Gene

Latest Assembly
chr8:12,721,900-12,756,073
(GRCh38/hg38)
Size:
34,174 bases
Orientation:
Minus strand

Previous Assembly
chr8:12,579,415-12,613,035
(GRCh37/hg19 by Entrez Gene)
Size:
33,621 bases
Orientation:
Minus strand

chr8:12,579,403-12,613,582
(GRCh37/hg19 by Ensembl)
Size:
34,180 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr8(PATCHES):5,917,253-5,950,889 (-)

Genomic View for LONRF1 Gene

Genes around LONRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF1 Gene

Proteins for LONRF1 Gene

  • Protein details for LONRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RB8-LONF1_HUMAN
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 1
    Protein Accession:
    Q17RB8
    Secondary Accessions:
    • B4DM29
    • B4DU84
    • Q8TEA0
    • Q9BSV1

    Protein attributes for LONRF1 Gene

    Size:
    773 amino acids
    Molecular mass:
    86725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17382.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17386.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85052.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAG59741.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAG62246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LONRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LONRF1 Gene

Post-translational modifications for LONRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LONRF1 Gene

Domains & Families for LONRF1 Gene

Gene Families for LONRF1 Gene

Suggested Antigen Peptide Sequences for LONRF1 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 191 (LONF1_HUMAN)
genes like me logo Genes that share domains with LONRF1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LONRF1 Gene

Function for LONRF1 Gene

Phenotypes From GWAS Catalog for LONRF1 Gene

Gene Ontology (GO) - Molecular Function for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LONRF1: view
genes like me logo Genes that share phenotypes with LONRF1: view

miRNA for LONRF1 Gene

miRTarBase miRNAs that target LONRF1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LONRF1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF1 Gene

Localization for LONRF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF1 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LONRF1 Gene

Pathways & Interactions for LONRF1 Gene

genes like me logo Genes that share pathways with LONRF1: view

Gene Ontology (GO) - Biological Process for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for SIGNOR curated interactions for LONRF1 Gene

Drugs & Compounds for LONRF1 Gene

No Compound Related Data Available

Transcripts for LONRF1 Gene

mRNA/cDNA for LONRF1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LONRF1

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for LONRF1 Gene

GeneLoc Exon Structure for
LONRF1

Expression for LONRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LONRF1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LONRF1 Gene



Protein tissue co-expression partners for LONRF1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LONRF1

SOURCE GeneReport for Unigene cluster for LONRF1 Gene:

Hs.180178

Evidence on tissue expression from TISSUES for LONRF1 Gene

  • Nervous system(4.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with LONRF1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LONRF1 Gene

Orthologs for LONRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LONRF1 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LONRF1 29 30
  • 92.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LONRF1 29 30
  • 91.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lonrf1 29
  • 85.6 (n)
Mouse
(Mus musculus)
Mammalia Lonrf1 29 16 30
  • 84.82 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LONRF1 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LONRF1 29 30
  • 75.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LONRF1 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lonrf1 29
  • 63.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1931 29
Zebrafish
(Danio rerio)
Actinopterygii lonrf1l 29 30
  • 55.14 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG32369 30
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4463 30
  • 38 (a)
ManyToMany
Species where no ortholog for LONRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LONRF1 Gene

ENSEMBL:
Gene Tree for LONRF1 (if available)
TreeFam:
Gene Tree for LONRF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LONRF1: view image
Alliance of Genome Resources:
Additional Orthologs for LONRF1

Paralogs for LONRF1 Gene

Paralogs for LONRF1 Gene

(9) SIMAP similar genes for LONRF1 Gene using alignment to 4 proteins:

  • LONF1_HUMAN
  • E9PQH4_HUMAN
  • E9PRX6_HUMAN
  • H7C5V9_HUMAN
genes like me logo Genes that share paralogs with LONRF1: view

Variants for LONRF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LONRF1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1139354 -- p.Ile265Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LONRF1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LONRF1 Gene

Variant ID Type Subtype PubMed ID
dgv244e55 CNV gain 17911159
dgv246e55 CNV gain 17911159
esv2759593 CNV gain+loss 17122850
esv3616292 CNV loss 21293372
nsv1029648 CNV gain 25217958
nsv1077019 CNV deletion 25765185

Variation tolerance for LONRF1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LONRF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LONRF1
Leiden Open Variation Database (LOVD)
LONRF1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF1 Gene

Disorders for LONRF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LONRF1 Gene - From: COP

Disorder Aliases PubMed IDs
penile benign neoplasm
  • neoplasm of penis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LONRF1

genes like me logo Genes that share disorders with LONRF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LONRF1 Gene

Publications for LONRF1 Gene

  1. Comparative FISH-mapping of twelve loci in river buffalo and sheep chromosomes: comparison with HSA8p and HSA4q. (PMID: 18253036) Perucatti A … Iannuzzi L (Cytogenetic and genome research 2007) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. (PMID: 30652415) Liu Y … Chen L (Cancer medicine 2019) 3

Products for LONRF1 Gene

Sources for LONRF1 Gene