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Aliases for LONRF1 Gene

Aliases for LONRF1 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 1 2 3 5
  • RING Finger Protein 191 3 4
  • RNF191 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 1 3

External Ids for LONRF1 Gene

Previous GeneCards Identifiers for LONRF1 Gene

  • GC08M012624
  • GC08M011121
  • GC08M012579

Summaries for LONRF1 Gene

GeneCards Summary for LONRF1 Gene

LONRF1 (LON Peptidase N-Terminal Domain And Ring Finger 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF3.

Additional gene information for LONRF1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF1 Gene

Genomics for LONRF1 Gene

GeneHancer (GH) Regulatory Elements for LONRF1 Gene

Promoters and enhancers for LONRF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I012752 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552.1 +0.5 519 6.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 LONRF1 RPS3AP34 LOC649352 MIR3926-1
GH08I012725 Enhancer 1 Ensembl ENCODE 16.6 +29.4 29396 2.5 ELF3 FOXA2 BATF ZNF366 ZSCAN5C FOS ZNF362 JUNB CEBPB ZEB2 MIR3926-1 MIR3926-2 LONRF1 MIR5692A2
GH08I013120 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 -371.7 -371741 14.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF213 SP3 MXD4 REST DLC1 RNU6-842P RPS3AP34 ENSG00000255122 ALG1L12P LONRF1 TRMT9B LOC100421094 GC08P013101 GC08P013155
GH08I012764 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -10.0 -10042 3.1 HDGF PKNOX1 BATF IRF4 ZSCAN5C ATF7 BCLAF1 IKZF2 RUNX3 SMARCA5 GC08P012767 LONRF1 LINC00681 DLC1 LOC340357
GH08I012840 Enhancer 0.7 ENCODE 11.8 -84.8 -84774 0.2 CTCF USF1 MAX RAD21 RFX5 TEAD3 ARID2 ZNF26 SCRT2 ZNF143 LONRF1 RPS3AP34 TRMT9B ENSG00000255122 PIR55936 GC08P012821
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LONRF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LONRF1 gene promoter:

Genomic Locations for LONRF1 Gene

Genomic Locations for LONRF1 Gene
chr8:12,721,894-12,756,073
(GRCh38/hg38)
Size:
34,180 bases
Orientation:
Minus strand
chr8:12,579,403-12,613,582
(GRCh37/hg19)

Genomic View for LONRF1 Gene

Genes around LONRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF1 Gene

Proteins for LONRF1 Gene

  • Protein details for LONRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RB8-LONF1_HUMAN
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 1
    Protein Accession:
    Q17RB8
    Secondary Accessions:
    • B4DM29
    • B4DU84
    • Q8TEA0
    • Q9BSV1

    Protein attributes for LONRF1 Gene

    Size:
    773 amino acids
    Molecular mass:
    86725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17382.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17386.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85052.1; Type=Frameshift; Positions=463; Evidence={ECO:0000305}; Sequence=BAG59741.1; Type=Frameshift; Positions=293; Evidence={ECO:0000305}; Sequence=BAG62246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LONRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LONRF1 Gene

Post-translational modifications for LONRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LONRF1 Gene

Domains & Families for LONRF1 Gene

Gene Families for LONRF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LONRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LONRF1: view

No data available for UniProtKB/Swiss-Prot for LONRF1 Gene

Function for LONRF1 Gene

Phenotypes From GWAS Catalog for LONRF1 Gene

Gene Ontology (GO) - Molecular Function for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19549727
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with LONRF1: view

Phenotypes for LONRF1 Gene

genes like me logo Genes that share phenotypes with LONRF1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF1 Gene

Localization for LONRF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF1 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LONRF1 Gene

Pathways & Interactions for LONRF1 Gene

genes like me logo Genes that share pathways with LONRF1: view

Gene Ontology (GO) - Biological Process for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for SIGNOR curated interactions for LONRF1 Gene

Drugs & Compounds for LONRF1 Gene

No Compound Related Data Available

Transcripts for LONRF1 Gene

Unigene Clusters for LONRF1 Gene

LON peptidase N-terminal domain and ring finger 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for LONRF1 Gene

GeneLoc Exon Structure for
LONRF1
ECgene alternative splicing isoforms for
LONRF1

Expression for LONRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LONRF1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LONRF1 Gene



Protein tissue co-expression partners for LONRF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LONRF1 Gene:

LONRF1

SOURCE GeneReport for Unigene cluster for LONRF1 Gene:

Hs.180178

Evidence on tissue expression from TISSUES for LONRF1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with LONRF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LONRF1 Gene

Orthologs for LONRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LONRF1 34 33
  • 99.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LONRF1 33 34
  • 92.85 (n)
cow
(Bos Taurus)
Mammalia LONRF1 34 33
  • 91.59 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lonrf1 33
  • 85.6 (n)
mouse
(Mus musculus)
Mammalia Lonrf1 16 34 33
  • 84.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LONRF1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves LONRF1 33 34
  • 75.12 (n)
lizard
(Anolis carolinensis)
Reptilia LONRF1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf1 33
  • 63.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1931 33
zebrafish
(Danio rerio)
Actinopterygii lonrf1l 33 34
  • 55.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32369 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4463 34
  • 38 (a)
ManyToMany
Species where no ortholog for LONRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF1 Gene

ENSEMBL:
Gene Tree for LONRF1 (if available)
TreeFam:
Gene Tree for LONRF1 (if available)

Paralogs for LONRF1 Gene

Paralogs for LONRF1 Gene

(9) SIMAP similar genes for LONRF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LONRF1: view

Variants for LONRF1 Gene

Sequence variations from dbSNP and Humsavar for LONRF1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000102003 -- 12,738,697(-) A/T intron_variant
rs1000117366 -- 12,724,144(-) G/A intron_variant
rs1000128038 -- 12,746,092(-) C/A intron_variant
rs1000220036 -- 12,733,715(-) A/C intron_variant
rs1000261202 -- 12,743,044(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF1 Gene

Variant ID Type Subtype PubMed ID
dgv244e55 CNV gain 17911159
dgv246e55 CNV gain 17911159
esv2759593 CNV gain+loss 17122850
esv3616292 CNV loss 21293372
nsv1029648 CNV gain 25217958
nsv1077019 CNV deletion 25765185

Variation tolerance for LONRF1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LONRF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LONRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF1 Gene

Disorders for LONRF1 Gene

Additional Disease Information for LONRF1

No disorders were found for LONRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LONRF1 Gene

Publications for LONRF1 Gene

  1. Comparative FISH-mapping of twelve loci in river buffalo and sheep chromosomes: comparison with HSA8p and HSA4q. (PMID: 18253036) Perucatti A … Iannuzzi L (Cytogenetic and genome research 2007) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58

Products for LONRF1 Gene

Sources for LONRF1 Gene

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