Aliases for LOC117135106 Gene
External Ids for LOC117135106 Gene
- Entrez Gene: 117135106
This locus represents an enhancer located approximately 60 kb upstream of the TMPRSS2 (transmembrane serine protease 2) gene, which functions as an entry gene for human coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). The extended TMPRSS2 5' regulatory region is responsive to androgen receptor (AR), and it drives expression of a TMPRSS2-ERG or TMPRSS2-ETV1 oncogenic fusion gene in androgen-dependent prostate cancers. This subregion functions as an AR-responsive enhancer that can activate a heterologous promoter in transfected VCaP prostate cancer cells, and it also has non-AR-responsive activity in LNCaP cells. An AR binding site (ARBS) within this sequence can bind the AR protein in VCaP cells. [provided by RefSeq, Apr 2020]
GeneCards Summary for LOC117135106 Gene
LOC117135106 (TMPRSS2 Androgen Receptor-Responsive -60 Kb Enhancer) is a Biological Region gene. Diseases associated with LOC117135106 include Covid-19.