Aliases for LOC117134608 Gene
External Ids for LOC117134608 Gene
- Entrez Gene: 117134608
This locus represents an enhancer located approximately 13 kb upstream of the TMPRSS2 (transmembrane serine protease 2) gene, which functions as an entry gene for human coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). The extended TMPRSS2 5' regulatory region is responsive to androgen receptor (AR), and it drives expression of a TMPRSS2-ERG or TMPRSS2-ETV1 oncogenic fusion gene in androgen-dependent prostate cancers. This subregion functions as an AR-activated enhancer that regulates both the TMPRSS2 oncogene and the more distally located PCSEAT non-coding gene (also known as PRCAT38) in prostate cancer cells. This region includes binding sites for AR (androgen receptor), GATA2 (GATA binding protein 2) and POU2F1 (POU class 2 homeobox 1, also known as OCT1), and its activity is also mediated by FOXA1 (forkhead box A1). A single nucleotide polymorphism within the AR response element, the A allele of rs8134378, was shown to impede AR functioning in reporter gene assays. This region forms chromatin looping interactions with the TMPRSS2 proximal promoter and with another enhancer located approximately 17 kb upstream of the TMPRSS2 gene, where these looping interactions are mediated by AR/FOXA1 binding and by p300 acetyltransferase activity. [provided by RefSeq, Apr 2020]
GeneCards Summary for LOC117134608 Gene
LOC117134608 (TMPRSS2 Androgen Receptor-Responsive -13 Kb Enhancer) is a Biological Region gene. Diseases associated with LOC117134608 include Covid-19.