This locus represents the 5'-proximal promoter region of the TMPRSS2 (transmembrane serine protease 2) gene, which functions as an entry gene for human coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). The extended promoter is responsive to androgen receptor (AR), and it drives expression of a TMPRSS2-ERG or TMPRSS2-ETV1 oncogenic fusion gene in androgen-depend... See more...

Aliases for LOC117134604 Gene

Aliases for LOC117134604 Gene

  • TMPRSS2 Promoter Region 3
  • TMPRSS2 Regulatory Region N 3

External Ids for LOC117134604 Gene

Summaries for LOC117134604 Gene

Entrez Gene Summary for LOC117134604 Gene

  • This locus represents the 5'-proximal promoter region of the TMPRSS2 (transmembrane serine protease 2) gene, which functions as an entry gene for human coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). The extended promoter is responsive to androgen receptor (AR), and it drives expression of a TMPRSS2-ERG or TMPRSS2-ETV1 oncogenic fusion gene in androgen-dependent prostate cancers. This promoter subregion was shown to drive expression of TMPRSS2 by reporter assays in A549 lung adenocarcinoma cells, with positive regulation by the Sp1 and EGR1 transcription factors. Those transcription factors bind to a guanine-rich cis-regulatory element that can adopt a G-quadruplex structure in the presence of potassium ions. Compounds that stabilize that structure can repress promoter activity and inhibit influenza A virus propagation in vitro, and they are thus candidates for anti-viral small molecule drugs. An overlapping fragment within this genomic region was validated as a functional enhancer that can activate an SV40 promoter in reporter assays in LNCaP prostate cancer cells. The enhancer subregion was also shown to weakly associate with AR, and it forms chromatin looping interactions with an AR-responsive enhancer located approximately 13 kb upstream of the TMPRSS2 gene. [provided by RefSeq, May 2020]

GeneCards Summary for LOC117134604 Gene

LOC117134604 (TMPRSS2 Promoter Region) is a Biological Region gene. Diseases associated with LOC117134604 include Covid-19.

Additional gene information for LOC117134604 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC117134604 Gene

Genomics for LOC117134604 Gene

Genomic Locations for LOC117134604 Gene

Genomic Locations for LOC117134604 Gene
chr21:41,507,255-41,509,135
(GRCh38/hg38)
Size:
1,881 bases
Orientation:
Plus strand

Genomic View for LOC117134604 Gene

Genes around LOC117134604 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOC117134604 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOC117134604 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOC117134604 Gene

No data available for GeneHancer (GH) Regulatory Elements for LOC117134604 Gene

Proteins for LOC117134604 Gene

Post-translational modifications for LOC117134604 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC117134604 Gene

Domains & Families for LOC117134604 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC117134604 Gene

Function for LOC117134604 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC117134604 Gene

Localization for LOC117134604 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC117134604 Gene

Pathways & Interactions for LOC117134604 Gene

PathCards logo

SuperPathways for LOC117134604 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LOC117134604 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC117134604 Gene

Drugs & Compounds for LOC117134604 Gene

No Compound Related Data Available

Transcripts for LOC117134604 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC117134604 Gene

No ASD Table

Relevant External Links for LOC117134604 Gene

GeneLoc Exon Structure for
LOC117134604

No data available for mRNA/cDNA for LOC117134604 Gene

Expression for LOC117134604 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC117134604 Gene

Orthologs for LOC117134604 Gene

No data available for Orthologs and Evolution for LOC117134604 Gene

Paralogs for LOC117134604 Gene

No data available for Paralogs for LOC117134604 Gene

Variants for LOC117134604 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC117134604 Gene

Disorders for LOC117134604 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LOC117134604 Gene - From: GeneCards

Disorder Aliases PubMed IDs
covid-19
  • 2019 novel coronavirus
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LOC117134604: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for LOC117134604 Gene

Publications for LOC117134604 Gene

  1. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? (PMID: 32276929) Stopsack KH … Kantoff PW (Cancer discovery 2020) 3
  2. Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression. (PMID: 32376987) Shen LW … Zhang W (Scientific reports 2020) 3
  3. Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer. (PMID: 31405024) Chen Z … Huang D (Cells 2019) 3
  4. MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells. (PMID: 30076933) Ito S … Ukimura O (Biochimica et biophysica acta. Gene regulatory mechanisms 2018) 3
  5. Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer. (PMID: 28050800) Todorova K … Hayrabedyan S (Hormones & cancer 2017) 3

No data available for Mastermind for LOC117134604 Gene

Products for LOC117134604 Gene

Sources for LOC117134604 Gene