External Ids for LOC117134604 Gene
- Entrez Gene: 117134604
This locus represents the 5'-proximal promoter region of the TMPRSS2 (transmembrane serine protease 2) gene, which functions as an entry gene for human coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). The extended promoter is responsive to androgen receptor (AR), and it drives expression of a TMPRSS2-ERG or TMPRSS2-ETV1 oncogenic fusion gene in androgen-dependent prostate cancers. This promoter subregion was shown to drive expression of TMPRSS2 by reporter assays in A549 lung adenocarcinoma cells, with positive regulation by the Sp1 and EGR1 transcription factors. Those transcription factors bind to a guanine-rich cis-regulatory element that can adopt a G-quadruplex structure in the presence of potassium ions. Compounds that stabilize that structure can repress promoter activity and inhibit influenza A virus propagation in vitro, and they are thus candidates for anti-viral small molecule drugs. An overlapping fragment within this genomic region was validated as a functional enhancer that can activate an SV40 promoter in reporter assays in LNCaP prostate cancer cells. The enhancer subregion was also shown to weakly associate with AR, and it forms chromatin looping interactions with an AR-responsive enhancer located approximately 13 kb upstream of the TMPRSS2 gene. [provided by RefSeq, May 2020]
GeneCards Summary for LOC117134604 Gene
LOC117134604 (TMPRSS2 Promoter Region) is a Biological Region gene. Diseases associated with LOC117134604 include Covid-19.