External Ids for LOC114255744 Gene
- Entrez Gene: 114255744
This genomic region, which is located in an intron of the limb development membrane protein 1 (LMBR1) gene, can activate a minimal gata2 promoter in the zone of polarizing activity (ZPA) domain of developing fins in transgenic zebrafish. It is thought to be a shadow enhancer of the ZPA regulatory sequence (ZRS), which is also in the same LMBR1 intron and which regulates expression of the sonic hedgehog signaling molecule (SHH) gene during human limb development. Deletions of both the orthologous ZRS and shadow ZRS (sZRS) enhancers in the medaka genome suggest that both enhancer regions are necessary for sonic hedgehog gene expression and pectoral fin development. [provided by RefSeq, Feb 2019]
GeneCards Summary for LOC114255744 Gene
LOC114255744 (ZRS Shadow Enhancer) is a Biological Region gene.