Aliases for LOC111674464 Gene
External Ids for LOC111674464 Gene
- Entrez Gene: 111674464
This genomic region represents closely situated DNase I hypersensitive sites in the first intron of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It includes a conserved element that can function as a CFTR enhancer in Caco2 colorectal adenocarcinoma cells, and which shows cooperative activity with the intron 11 and +15.6 kb CFTR enhancers. Binding sites for multiple transcription factors, including SRF, HNF1 and TCF4, have been found in this region, and it has also been shown to associate with FOXA1, FOXA2 and CDX2 in vivo. This region can physically interact with the CFTR promoter and other CFTR regulatory elements in a larger topologically associating domain (TAD). [provided by RefSeq, Nov 2018]
GeneCards Summary for LOC111674464 Gene
LOC111674464 (CFTR Intron 1 Enhancer) is a Biological Region gene. Diseases associated with LOC111674464 include Cystic Fibrosis.