Aliases for LOC111365221 Gene
External Ids for LOC111365221 Gene
- Entrez Gene: 111365221
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. A sub-region was validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in HepG2 liver carcinoma cells. This enhancer contains a conserved motif for the HNF1 activator, and mutation of the motif results in reduced enhancer activity. This region was also validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using MPRAs) in HepG2 cells (group: HepG2 Activating DNase matched - State 1:Tss, active promoter, TSS/CpG island region). It also displayed repressive activity by Sharpr-MPRA in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 23:Low, low signal proximal to active elements). [provided by RefSeq, Mar 2018]
GeneCards Summary for LOC111365221 Gene
LOC111365221 (HNF1 Motif-Containing MPRA Enhancer 116) is a Biological Region gene.