Aliases for LOC111365168 Gene
External Ids for LOC111365168 Gene
- Entrez Gene: 111365168
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 22:ReprW, weaker Polycomb repression) and K562 erythroleukemia cells (group: K562 Activating DNase matched - State 8:EnhW, candidate weak enhancer and open chromatin). A sub-region also functioned as an enhancer by high-throughput massively parallel reporter assays (MPRAs) in both HepG2 and K562 cells. The sub-region contains a conserved motif for the NFE2L2 activator, and mutation of the motif results in reduced enhancer activity. [provided by RefSeq, Dec 2018]
GeneCards Summary for LOC111365168 Gene
LOC111365168 (NFE2L2 Motif-Containing MPRA Enhancer 148) is a Biological Region gene.