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Aliases for LOC111258501 Gene

Aliases for LOC111258501 Gene

  • MEIS1 5' Regulatory Region 3
  • E1 -2kb Enhancer Of MEIS1 3
  • HHc2:066543 3

External Ids for LOC111258501 Gene

Summaries for LOC111258501 Gene

Entrez Gene Summary for LOC111258501 Gene

  • This region represents the promoter and a nearby upstream enhancer of the Meis homeobox 1 gene. Both the promoter and enhancer correspond to DNase I hypersensitive sites. The promoter region can act as an enhancer on a heterologous promoter and drive expression of a transgene in the developing nervous system. Activity of this sequence is induced by association of Spi-1 proto-oncogene and E74 like ETS transcription factor 1. This region has been found to be epigenetically silenced by DNA methylation in tumor cells. [provided by RefSeq, Oct 2017]

GeneCards Summary for LOC111258501 Gene

LOC111258501 (MEIS1 5' Regulatory Region) is a Biological Region gene.

Additional gene information for LOC111258501 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC111258501 Gene

Genomics for LOC111258501 Gene

Genomic Locations for LOC111258501 Gene

Genomic Locations for LOC111258501 Gene
chr2:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC111258501 Gene

RefSeq DNA sequence for LOC111258501 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC111258501 Gene

Proteins for LOC111258501 Gene

Post-translational modifications for LOC111258501 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC111258501 Gene

Domains & Families for LOC111258501 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LOC111258501 Gene

Function for LOC111258501 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC111258501 Gene

Localization for LOC111258501 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC111258501 Gene

Pathways & Interactions for LOC111258501 Gene

PathCards logo

SuperPathways for LOC111258501 Gene

No Data Available

Interacting Proteins for LOC111258501 Gene

Gene Ontology (GO) - Biological Process for LOC111258501 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LOC111258501 Gene

Drugs & Compounds for LOC111258501 Gene

No Compound Related Data Available

Transcripts for LOC111258501 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC111258501 Gene

No ASD Table

No data available for mRNA/cDNA for LOC111258501 Gene

Expression for LOC111258501 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC111258501 Gene

Orthologs for LOC111258501 Gene

No data available for Orthologs and Evolution for LOC111258501 Gene

Paralogs for LOC111258501 Gene

No data available for Paralogs for LOC111258501 Gene

Variants for LOC111258501 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC111258501 Gene

Disorders for LOC111258501 Gene

No disorders were found for LOC111258501 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC111258501 Gene

Publications for LOC111258501 Gene

  1. DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. (PMID: 26434589) Ferreira HJ … Esteller M (Oncogene 2016) 3 58
  2. Promoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia. (PMID: 25585874) Musialik E … Siedlecki JA (Molecular medicine reports 2015) 3 58
  3. PU.1 affects proliferation of the human acute myeloid leukemia U937 cell line by directly regulating MEIS1. (PMID: 26622774) Zhou J … Guan Y (Oncology letters 2015) 3 58
  4. Delineating MEIS1 cis-regulatory elements active in hematopoietic cells. (PMID: 24097337) Xiang P … Humphries KR (Leukemia 2014) 3 58
  5. The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors. (PMID: 24244575) Dihal AA … Boer JM (PloS one 2013) 3 58

No data available for External Links for LOC111258501 Gene

Products for LOC111258501 Gene

Sources for LOC111258501 Gene

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