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Aliases for LOC111255645 Gene

Aliases for LOC111255645 Gene

  • TNFRSF10A 5' Regulatory Region 3

External Ids for LOC111255645 Gene

Summaries for LOC111255645 Gene

Entrez Gene Summary for LOC111255645 Gene

  • This record represents the 5' regulatory region of the TNF receptor superfamily member 10a (TNFRSF10A, also known as DR4 or TRAIL-R1) gene. This promoter is regulated by tumor protein p53 through an intronic site. Association of nuclear factor kappa B, AP-1 family transcription factors, DNA-damage inducible transcript 3 protein, and retinoic acid receptor induce expression of this promoter by acting through recognition elements located upstream of the start of transcription. This region may be epigenetically suppressed by DNA cytosine methylation. [provided by RefSeq, Oct 2017]

GeneCards Summary for LOC111255645 Gene

LOC111255645 (TNFRSF10A 5' Regulatory Region) is a Biological Region gene.

Additional gene information for LOC111255645 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC111255645 Gene

Genomics for LOC111255645 Gene

Genomic Locations for LOC111255645 Gene

Genomic Locations for LOC111255645 Gene
chr8:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC111255645 Gene

RefSeq DNA sequence for LOC111255645 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC111255645 Gene

Proteins for LOC111255645 Gene

Post-translational modifications for LOC111255645 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC111255645 Gene

Domains & Families for LOC111255645 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LOC111255645 Gene

Function for LOC111255645 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC111255645 Gene

Localization for LOC111255645 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC111255645 Gene

Pathways & Interactions for LOC111255645 Gene

PathCards logo

SuperPathways for LOC111255645 Gene

No Data Available

Interacting Proteins for LOC111255645 Gene

Gene Ontology (GO) - Biological Process for LOC111255645 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LOC111255645 Gene

Drugs & Compounds for LOC111255645 Gene

No Compound Related Data Available

Transcripts for LOC111255645 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC111255645 Gene

No ASD Table

No data available for mRNA/cDNA for LOC111255645 Gene

Expression for LOC111255645 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC111255645 Gene

Orthologs for LOC111255645 Gene

No data available for Orthologs and Evolution for LOC111255645 Gene

Paralogs for LOC111255645 Gene

No data available for Paralogs for LOC111255645 Gene

Variants for LOC111255645 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC111255645 Gene

Disorders for LOC111255645 Gene

No disorders were found for LOC111255645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC111255645 Gene

Publications for LOC111255645 Gene

  1. Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition. (PMID: 27576686) Yao W … Sun SY (The Journal of biological chemistry 2016) 3 58
  2. Effect of DR4 promoter methylation on the TRAIL-induced apoptosis in lung squamous carcinoma cell. (PMID: 26238205) Wang W … Wu M (Oncology reports 2015) 3 58
  3. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. (PMID: 25770212) Li T … Liu X (The Journal of biological chemistry 2015) 3 58
  4. Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease. (PMID: 25232375) Wang Y … Bi J (International journal of clinical and experimental medicine 2014) 3 58
  5. Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions. (PMID: 22948392) Zhuang H … Hua ZC (Journal of molecular medicine (Berlin, Germany) 2013) 3 58

No data available for External Links for LOC111255645 Gene

Products for LOC111255645 Gene

Sources for LOC111255645 Gene

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