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Aliases for LOC110740340 Gene

Aliases for LOC110740340 Gene

  • CYP2D6 Promoter 3

External Ids for LOC110740340 Gene

Summaries for LOC110740340 Gene

Entrez Gene Summary for LOC110740340 Gene

  • This region represents the promoter of the cytochrome P450 family 2 subfamily D member 6 (CYP2D6) gene. This promoter is induced by binding of hepatocyte nuclear factor 4 alpha. Activity of this sequence may be further stimulated by Kruppel like factor 9 and peroxisome proliferator activated receptor alpha, and is suppressed by nitric oxide and estrogen. Naturally-occurring polymorphic sites in this region, including rs1080985 in the distal promoter, are associated with expression of CYP2D6 and may have phenotypic consequences. [provided by RefSeq, Jul 2017]

GeneCards Summary for LOC110740340 Gene

LOC110740340 (CYP2D6 Promoter) is a Biological Region gene.

Additional gene information for LOC110740340 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC110740340 Gene

Genomics for LOC110740340 Gene

Genomic Locations for LOC110740340 Gene

Genomic Locations for LOC110740340 Gene
chr22:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110740340 Gene

RefSeq DNA sequence for LOC110740340 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110740340 Gene

Proteins for LOC110740340 Gene

Post-translational modifications for LOC110740340 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110740340 Gene

Domains & Families for LOC110740340 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LOC110740340 Gene

Function for LOC110740340 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110740340 Gene

Localization for LOC110740340 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110740340 Gene

Pathways & Interactions for LOC110740340 Gene

PathCards logo

SuperPathways for LOC110740340 Gene

No Data Available

Interacting Proteins for LOC110740340 Gene

Gene Ontology (GO) - Biological Process for LOC110740340 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LOC110740340 Gene

Drugs & Compounds for LOC110740340 Gene

No Compound Related Data Available

Transcripts for LOC110740340 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110740340 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110740340 Gene

Expression for LOC110740340 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110740340 Gene

Orthologs for LOC110740340 Gene

No data available for Orthologs and Evolution for LOC110740340 Gene

Paralogs for LOC110740340 Gene

No data available for Paralogs for LOC110740340 Gene

Variants for LOC110740340 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110740340 Gene

Disorders for LOC110740340 Gene

No disorders were found for LOC110740340 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110740340 Gene

Publications for LOC110740340 Gene

  1. Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6. (PMID: 28403802) Kent R … Jeong H (Drug metabolism letters 2017) 3 58
  2. Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner. (PMID: 25926433) Pan X … Jeong H (Drug metabolism and disposition: the biological fate of chemicals 2015) 3 58
  3. Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice. (PMID: 25943116) Pan X … Jeong H (Molecular pharmacology 2015) 3 58
  4. Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine. (PMID: 26574146) He ZX … Zhou SF (Drug metabolism reviews 2015) 3 58
  5. Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. (PMID: 24318876) Koh KH … Jeong H (The Journal of biological chemistry 2014) 3 58

No data available for External Links for LOC110740340 Gene

Products for LOC110740340 Gene

Sources for LOC110740340 Gene

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