This region represents the promoter of the cytochrome P450 family 2 subfamily C member 8 (CYP2C8) gene. Activity of this promoter is stimulated by xenobiotics and glucocorticoids. Hepatocyte nuclear factor 4 alpha, nuclear receptor subfamily 1 group I family members, RAR-related orphan receptor, and peroxisome proliferator activated receptor recognize and bind to discrete sites... See more...

Aliases for LOC110599571 Gene

Aliases for LOC110599571 Gene

  • CYP2C8 Promoter 3

External Ids for LOC110599571 Gene

Summaries for LOC110599571 Gene

Entrez Gene Summary for LOC110599571 Gene

  • This region represents the promoter of the cytochrome P450 family 2 subfamily C member 8 (CYP2C8) gene. Activity of this promoter is stimulated by xenobiotics and glucocorticoids. Hepatocyte nuclear factor 4 alpha, nuclear receptor subfamily 1 group I family members, RAR-related orphan receptor, and peroxisome proliferator activated receptor recognize and bind to discrete sites in this sequence, positively regulating promoter activity. [provided by RefSeq, Jul 2017]

GeneCards Summary for LOC110599571 Gene

LOC110599571 (CYP2C8 Promoter) is a Biological Region gene.

Additional gene information for LOC110599571 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC110599571 Gene

Genomics for LOC110599571 Gene

Genomic Locations for LOC110599571 Gene

Genomic Locations for LOC110599571 Gene
chr10:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110599571 Gene

RefSeq DNA sequence for LOC110599571 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110599571 Gene

Proteins for LOC110599571 Gene

Post-translational modifications for LOC110599571 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110599571 Gene

Domains & Families for LOC110599571 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC110599571 Gene

Function for LOC110599571 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110599571 Gene

Localization for LOC110599571 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110599571 Gene

Pathways & Interactions for LOC110599571 Gene

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SuperPathways for LOC110599571 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC110599571 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC110599571 Gene

Drugs & Compounds for LOC110599571 Gene

No Compound Related Data Available

Transcripts for LOC110599571 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110599571 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110599571 Gene

Expression for LOC110599571 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110599571 Gene

Orthologs for LOC110599571 Gene

No data available for Orthologs and Evolution for LOC110599571 Gene

Paralogs for LOC110599571 Gene

No data available for Paralogs for LOC110599571 Gene

Variants for LOC110599571 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110599571 Gene

Disorders for LOC110599571 Gene

No disorders were found for LOC110599571 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110599571 Gene

Publications for LOC110599571 Gene

  1. CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor α in Human Liver. (PMID: 26467040) Makia NL … Goldstein JA (Molecular pharmacology 2016) 3 54
  2. Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes. (PMID: 20086032) Rana R … Goldstein JA (Drug metabolism and disposition: the biological fate of chemicals 2010) 3 54
  3. Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. (PMID: 19164466) Chen Y … Goldstein JA (The Journal of pharmacology and experimental therapeutics 2009) 3 54
  4. The transcriptional regulation of the human CYP2C genes. (PMID: 19702536) Chen Y … Goldstein JA (Current drug metabolism 2009) 3 54
  5. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. (PMID: 15933212) Ferguson SS … Goldstein JA (Molecular pharmacology 2005) 3 54

No data available for Mastermind for LOC110599571 Gene

Products for LOC110599571 Gene

Sources for LOC110599571 Gene