This region represents the promoter of the cytochrome P450 family 2 subfamily C member 19 (CYP2C19) gene. Activity of this promoter is stimulated by xenobiotics and glucocorticoids, and may be negatively regulated by estrogen. Hepatocyte nuclear factor 4 alpha, nuclear receptor subfamily 1 group I family members, and GATA binding proteins recognize and bind to discrete sites in... See more...

Aliases for LOC110599570 Gene

Aliases for LOC110599570 Gene

  • CYP2C19 Promoter 3

External Ids for LOC110599570 Gene

Summaries for LOC110599570 Gene

Entrez Gene Summary for LOC110599570 Gene

  • This region represents the promoter of the cytochrome P450 family 2 subfamily C member 19 (CYP2C19) gene. Activity of this promoter is stimulated by xenobiotics and glucocorticoids, and may be negatively regulated by estrogen. Hepatocyte nuclear factor 4 alpha, nuclear receptor subfamily 1 group I family members, and GATA binding proteins recognize and bind to discrete sites in this sequence. Naturally-occurring sequence variation in this region can influence activity of this promoter. [provided by RefSeq, Jul 2017]

GeneCards Summary for LOC110599570 Gene

LOC110599570 (CYP2C19 Promoter) is a Biological Region gene.

Additional gene information for LOC110599570 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC110599570 Gene

Genomics for LOC110599570 Gene

Genomic Locations for LOC110599570 Gene

Genomic Locations for LOC110599570 Gene
chr10:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110599570 Gene

RefSeq DNA sequence for LOC110599570 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110599570 Gene

Proteins for LOC110599570 Gene

Post-translational modifications for LOC110599570 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110599570 Gene

Domains & Families for LOC110599570 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC110599570 Gene

Function for LOC110599570 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110599570 Gene

Localization for LOC110599570 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110599570 Gene

Pathways & Interactions for LOC110599570 Gene

PathCards logo

SuperPathways for LOC110599570 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC110599570 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC110599570 Gene

Drugs & Compounds for LOC110599570 Gene

No Compound Related Data Available

Transcripts for LOC110599570 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110599570 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110599570 Gene

Expression for LOC110599570 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110599570 Gene

Orthologs for LOC110599570 Gene

No data available for Orthologs and Evolution for LOC110599570 Gene

Paralogs for LOC110599570 Gene

No data available for Paralogs for LOC110599570 Gene

Variants for LOC110599570 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LOC110599570 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs12248560 Drug Response: citalopram response - Metabolism/PK; clopidogrel response - Dosage, Efficacy, Toxicity/ADR; escitalopram response - Metabolism/PK 94,761,900( ) C/A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110599570 Gene

Disorders for LOC110599570 Gene

No disorders were found for LOC110599570 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110599570 Gene

Publications for LOC110599570 Gene

  1. Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells. (PMID: 27467078) Sun H … Chen H (PloS one 2016) 3 54
  2. Regulatory polymorphisms in CYP2C19 affecting hepatic expression. (PMID: 23412869) Sanford JC … Wang D (Drug metabolism and drug interactions 2013) 3 54
  3. Transcriptional regulation of CYP2C19 and its role in altered enzyme activity. (PMID: 22804232) Uppugunduri CR … Ansari M (Current drug metabolism 2012) 3 54
  4. Functional characterization of promoter region polymorphisms of human CYP2C19 gene. (PMID: 21152987) Satyanarayana Chakradhara Rao U … Chandrasekaran A (Molecular biology reports 2011) 3 54
  5. The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression. (PMID: 20206639) Mwinyi J … Ingelman-Sundberg M (Life sciences 2010) 3 54

No data available for Mastermind for LOC110599570 Gene

Products for LOC110599570 Gene

Sources for LOC110599570 Gene