This region represents the promoter of the cytochrome P450 family 2 subfamily C member 9 (CYP2C9) gene. Activity of this promoter is induced by xenobiotics, vitamin D, estrogens, and glucocorticoids. Hepatocyte nuclear factor 4 alpha, nuclear receptor subfamily 1 group I family members, and GATA binding proteins recognize discrete sites in this sequence to promote transcription... See more...

Aliases for LOC110599569 Gene

Aliases for LOC110599569 Gene

  • CYP2C9 Promoter 3

External Ids for LOC110599569 Gene

Summaries for LOC110599569 Gene

Entrez Gene Summary for LOC110599569 Gene

  • This region represents the promoter of the cytochrome P450 family 2 subfamily C member 9 (CYP2C9) gene. Activity of this promoter is induced by xenobiotics, vitamin D, estrogens, and glucocorticoids. Hepatocyte nuclear factor 4 alpha, nuclear receptor subfamily 1 group I family members, and GATA binding proteins recognize discrete sites in this sequence to promote transcription. Fos and JunD proto-oncogenes bind to two different AP-1 motifs, which may then loop together, resulting in a formation of a positive regulatory complex. Naturally-occurring sequence variation in this region was found to influence promoter activity, possibly through disruption of transcription factor binding sites. [provided by RefSeq, Jul 2017]

GeneCards Summary for LOC110599569 Gene

LOC110599569 (CYP2C9 Promoter) is a Biological Region gene.

Additional gene information for LOC110599569 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC110599569 Gene

Genomics for LOC110599569 Gene

Genomic Locations for LOC110599569 Gene

Genomic Locations for LOC110599569 Gene
chr10:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110599569 Gene

RefSeq DNA sequence for LOC110599569 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110599569 Gene

Proteins for LOC110599569 Gene

Post-translational modifications for LOC110599569 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110599569 Gene

Domains & Families for LOC110599569 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC110599569 Gene

Function for LOC110599569 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110599569 Gene

Localization for LOC110599569 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110599569 Gene

Pathways & Interactions for LOC110599569 Gene

PathCards logo

SuperPathways for LOC110599569 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC110599569 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC110599569 Gene

Drugs & Compounds for LOC110599569 Gene

No Compound Related Data Available

Transcripts for LOC110599569 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110599569 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110599569 Gene

Expression for LOC110599569 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110599569 Gene

Orthologs for LOC110599569 Gene

No data available for Orthologs and Evolution for LOC110599569 Gene

Paralogs for LOC110599569 Gene

No data available for Paralogs for LOC110599569 Gene

Variants for LOC110599569 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110599569 Gene

Disorders for LOC110599569 Gene

No disorders were found for LOC110599569 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110599569 Gene

Publications for LOC110599569 Gene

  1. Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25. (PMID: 27273787) Xu JY … Zhang SY (Environmental toxicology 2017) 3 54
  2. Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. (PMID: 25391650) Englert NA … Surapureddi S (The Journal of biological chemistry 2015) 3 54
  3. Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its Metabolites. (PMID: 25977700) Chen Q … Hu H (Evidence-based complementary and alternative medicine : eCAM 2015) 3 54
  4. Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping. (PMID: 24830941) Makia NL … Goldstein JA (Molecular pharmacology 2014) 3 54
  5. Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression. (PMID: 24960263) Shi Z … Zhang SY (Biochemical pharmacology 2014) 3 54

No data available for Mastermind for LOC110599569 Gene

Products for LOC110599569 Gene

Sources for LOC110599569 Gene