Aliases for LOC110594336 Gene
External Ids for LOC110594336 Gene
- Entrez Gene: 110594336
This region is a highly variable minisatellite region that overlaps the serine incorporator 2 (SERINC2) gene on the p arm of chromosome 1. The MS1 (D1S7) minisatellite is a highly unstable GC-rich variable number tandem repeat (VNTR) with a repeat unit length of nine nucleotides, with a consensus motif of CCACCCTATC. The repeat is an imperfect repeat, with a tandem array of similar, but non-identical repeats. When appended together, the consensus motif forms the PRDM9 A binding motif (LD hotspot motif), CCNCCNTNNCCNC. This region contains a meiotic recombination hotspot that overlaps the tandem repeat. This region shows very high heterozygosity, and has alleles ranging from 60 repeat units to greater than 1000 repeat units. The very high heterozygosity of this region makes it useful for forensic analyses. Instability at this locus is observed in both germline and somatic cells, with similar germline mutation rates observed in both males and females. Greater instability is seen in alleles with long arrays of homogeneous repeats, with deletions of the repeat observed. Repeat instability is also observed in colorectal carcinomas. [provided by RefSeq, Jul 2017]
GeneCards Summary for LOC110594336 Gene
LOC110594336 (MS1 Minisatellite Repeat Instability Region) is a Biological Region gene.