Aliases for LOC110485084 Gene
External Ids for LOC110485084 Gene
- Entrez Gene: 110485084
This region can undergo non-allelic homologous recombination (NAHR) with another region sharing high sequence similarity, the BCRA1P1 intergenic recombination region, which is located about 37 kb centromere-distal to this region on the reference genome. This region is found within an intron of the BRCA1, DNA repair associated (BRCA1) gene, and NAHR with the region near the BRCA1P1 gene can result in a deletion of the intervening sequence. Gene conversion events between the two regions have also been observed. Deletions from recombination between the two regions results in a chimeric gene with two exons from the BRCA1 pseudogene in place of the BRCA1 exons, and loss of the BRCA1 promoter region, causing loss of gene expression. This deletion is associated with hereditary forms of breast and ovarian cancers. The region represented here is composed of multiple sub-regions, named a-d, which have been identified as either NAHR exchange or gene conversion sites in different individuals. [provided by RefSeq, Jun 2017]
GeneCards Summary for LOC110485084 Gene
LOC110485084 (BRCA1 Intronic Recombination Region) is a Biological Region gene. Diseases associated with LOC110485084 include Breast-Ovarian Cancer, Familial 1.