Aliases for LOC110366354 Gene
External Ids for LOC110366354 Gene
- Entrez Gene: 110366354
This record represents the 5' regulatory region of the cytochrome P450 family 3 subfamily A member 4 gene. This sequence includes the proximal promoter as well as multiple enhancer modules present within the 12 kb upstream region. Xenobiotics, including rifampicin, induce activity of this regulatory region, as do vitamin D and glucocorticoids. The promoter and distal enhancers contain response elements that are stimulated by binding of nuclear receptor subfamily 1 group I member 2 (Nr1i2/Pxr) dimerized with retinoid X receptor alpha. These sites may also binds other nuclear receptors, thyroid receptor, and vitamin D receptor, which may positively regulate expression or compete with Nr1i2/Pxr binding and induction. This region is also regulated by binding of CCAAT/enhancer binding protein and hepatocyte nuclear factor 4 to defined recognition sites. [provided by RefSeq, May 2017]
GeneCards Summary for LOC110366354 Gene
LOC110366354 (CYP3A4 5' Regulatory Region) is a Biological Region gene.