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Aliases for LOC110366354 Gene

Aliases for LOC110366354 Gene

  • CYP3A4 5' Regulatory Region 3
  • Constitutive Liver Enhancer Module Of CYP3A4 (CLEM) 3
  • Xenobiotic Responsive Element Module (XREM) 3
  • CYP3A4 Promoter 3
  • CLEM 3
  • XREM 3

External Ids for LOC110366354 Gene

Summaries for LOC110366354 Gene

Entrez Gene Summary for LOC110366354 Gene

  • This record represents the 5' regulatory region of the cytochrome P450 family 3 subfamily A member 4 gene. This sequence includes the proximal promoter as well as multiple enhancer modules present within the 12 kb upstream region. Xenobiotics, including rifampicin, induce activity of this regulatory region, as do vitamin D and glucocorticoids. The promoter and distal enhancers contain response elements that are stimulated by binding of nuclear receptor subfamily 1 group I member 2 (Nr1i2/Pxr) dimerized with retinoid X receptor alpha. These sites may also binds other nuclear receptors, thyroid receptor, and vitamin D receptor, which may positively regulate expression or compete with Nr1i2/Pxr binding and induction. This region is also regulated by binding of CCAAT/enhancer binding protein and hepatocyte nuclear factor 4 to defined recognition sites. [provided by RefSeq, May 2017]

GeneCards Summary for LOC110366354 Gene

LOC110366354 (CYP3A4 5' Regulatory Region) is a Biological Region gene.

Additional gene information for LOC110366354 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC110366354 Gene

Genomics for LOC110366354 Gene

Genomic Locations for LOC110366354 Gene

Genomic Locations for LOC110366354 Gene
chr7:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110366354 Gene

RefSeq DNA sequence for LOC110366354 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110366354 Gene

Proteins for LOC110366354 Gene

Post-translational modifications for LOC110366354 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110366354 Gene

Domains & Families for LOC110366354 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LOC110366354 Gene

Function for LOC110366354 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110366354 Gene

Localization for LOC110366354 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110366354 Gene

Pathways & Interactions for LOC110366354 Gene

PathCards logo

SuperPathways for LOC110366354 Gene

No Data Available

Interacting Proteins for LOC110366354 Gene

Gene Ontology (GO) - Biological Process for LOC110366354 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LOC110366354 Gene

Drugs & Compounds for LOC110366354 Gene

No Compound Related Data Available

Transcripts for LOC110366354 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110366354 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110366354 Gene

Expression for LOC110366354 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110366354 Gene

Orthologs for LOC110366354 Gene

No data available for Orthologs and Evolution for LOC110366354 Gene

Paralogs for LOC110366354 Gene

No data available for Paralogs for LOC110366354 Gene

Variants for LOC110366354 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110366354 Gene

Disorders for LOC110366354 Gene

No disorders were found for LOC110366354 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110366354 Gene

Publications for LOC110366354 Gene

  1. Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin. (PMID: 28546420) Yan L … Zhang L (Molecular pharmacology 2017) 3 58
  2. A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease. (PMID: 27482056) Woolsey SJ … Tirona RG (Molecular pharmacology 2016) 3 58
  3. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers. (PMID: 26772622) Vyhlidal CA … Leeder JS (Drug metabolism and disposition: the biological fate of chemicals 2016) 3 58
  4. Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its Metabolites. (PMID: 25977700) Chen Q … Hu H (Evidence-based complementary and alternative medicine : eCAM 2015) 3 58
  5. Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression. (PMID: 25561723) Pondugula SR … Abbott KL (Drug metabolism and disposition: the biological fate of chemicals 2015) 3 58

No data available for External Links for LOC110366354 Gene

Products for LOC110366354 Gene

Sources for LOC110366354 Gene

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