This genomic region represents a conserved exonic enhancer (eExon 19) that overlaps an exon of the HDAC9 (histone deacetylase 9) gene on the p arm of chromosome 7. It can activate a Hsp68 promoter coupled to a reporter gene in the posterior limb bud of transgenic mice, or an E1b promoter in pectoral fin and branchial arch of transgenic zebrafish. This eExon is thought to be a t... See more...

Aliases for LOC110121291 Gene

Aliases for LOC110121291 Gene

  • EExon 19 TWIST1 Limb Enhancer 3
  • Enhancer Exon 19 Of HDAC9 3
  • VISTA Enhancer Hs2307 3

External Ids for LOC110121291 Gene

Summaries for LOC110121291 Gene

Entrez Gene Summary for LOC110121291 Gene

  • This genomic region represents a conserved exonic enhancer (eExon 19) that overlaps an exon of the HDAC9 (histone deacetylase 9) gene on the p arm of chromosome 7. It can activate a Hsp68 promoter coupled to a reporter gene in the posterior limb bud of transgenic mice, or an E1b promoter in pectoral fin and branchial arch of transgenic zebrafish. This eExon is thought to be a tissue-specific limb enhancer of the TWIST1 (twist family bHLH transcription factor 1) gene on the q arm of chromosome 7, where that gene encodes a transcription factor that inhibits the expression of the SHH (sonic hedgehog signaling molecule) gene in the anterior limb bud. [provided by RefSeq, Apr 2019]

GeneCards Summary for LOC110121291 Gene

LOC110121291 (EExon 19 TWIST1 Limb Enhancer) is a Biological Region gene.

Additional gene information for LOC110121291 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC110121291 Gene

Genomics for LOC110121291 Gene

Genomic Locations for LOC110121291 Gene

Genomic Locations for LOC110121291 Gene
chr7:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110121291 Gene

RefSeq DNA sequence for LOC110121291 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110121291 Gene

Proteins for LOC110121291 Gene

Post-translational modifications for LOC110121291 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110121291 Gene

Domains & Families for LOC110121291 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC110121291 Gene

Function for LOC110121291 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110121291 Gene

Localization for LOC110121291 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110121291 Gene

Pathways & Interactions for LOC110121291 Gene

PathCards logo

SuperPathways for LOC110121291 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC110121291 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC110121291 Gene

Drugs & Compounds for LOC110121291 Gene

No Compound Related Data Available

Transcripts for LOC110121291 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110121291 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110121291 Gene

Expression for LOC110121291 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110121291 Gene

Orthologs for LOC110121291 Gene

No data available for Orthologs and Evolution for LOC110121291 Gene

Paralogs for LOC110121291 Gene

No data available for Paralogs for LOC110121291 Gene

Variants for LOC110121291 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110121291 Gene

Disorders for LOC110121291 Gene

No disorders were found for LOC110121291 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110121291 Gene

Publications for LOC110121291 Gene

  1. Exonic enhancers: proceed with caution in exome and genome sequencing studies. (PMID: 26856702) Ahituv N (Genome medicine 2016) 3 54
  2. Coding exons function as tissue-specific enhancers of nearby genes. (PMID: 22442009) Birnbaum RY … Ahituv N (Genome research 2012) 3 54
  3. VISTA Enhancer Browser--a database of tissue-specific human enhancers. (PMID: 17130149) Visel A … Pennacchio LA (Nucleic acids research 2007) 3 54

No data available for Mastermind for LOC110121291 Gene

Products for LOC110121291 Gene

Sources for LOC110121291 Gene