This locus represents a conserved genomic element that can function as an enhancer. It can activate a Hsp68 promoter coupled to a LacZ reporter gene in transgenic mice. A sub-region was also validated as an enhancer-blocking element, which strongly blocked activation of an SV40 promoter by the HS2 beta-globin enhancer when positioned between the enhancer and promoter in transfe... See more...

Aliases for LOC110121252 Gene

Aliases for LOC110121252 Gene

  • VISTA Enhancer Hs2071 3
  • Greater CFTR Locus Negative Regulatory Element CR1 3
  • Greater CFTR Locus Enhancer-Blocking Element CR1 3

External Ids for LOC110121252 Gene

Summaries for LOC110121252 Gene

Entrez Gene Summary for LOC110121252 Gene

  • This locus represents a conserved genomic element that can function as an enhancer. It can activate a Hsp68 promoter coupled to a LacZ reporter gene in transgenic mice. A sub-region was also validated as an enhancer-blocking element, which strongly blocked activation of an SV40 promoter by the HS2 beta-globin enhancer when positioned between the enhancer and promoter in transfected K562, HeLa and 293T cells. [provided by RefSeq, Sep 2018]

GeneCards Summary for LOC110121252 Gene

LOC110121252 (VISTA Enhancer Hs2071) is a Biological Region gene.

Additional gene information for LOC110121252 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC110121252 Gene

Genomics for LOC110121252 Gene

Genomic Locations for LOC110121252 Gene

Genomic Locations for LOC110121252 Gene
chr7:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110121252 Gene

RefSeq DNA sequence for LOC110121252 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110121252 Gene

Proteins for LOC110121252 Gene

Post-translational modifications for LOC110121252 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110121252 Gene

Domains & Families for LOC110121252 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC110121252 Gene

Function for LOC110121252 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110121252 Gene

Localization for LOC110121252 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110121252 Gene

Pathways & Interactions for LOC110121252 Gene

PathCards logo

SuperPathways for LOC110121252 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC110121252 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC110121252 Gene

Drugs & Compounds for LOC110121252 Gene

No Compound Related Data Available

Transcripts for LOC110121252 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110121252 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110121252 Gene

Expression for LOC110121252 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110121252 Gene

Orthologs for LOC110121252 Gene

No data available for Orthologs and Evolution for LOC110121252 Gene

Paralogs for LOC110121252 Gene

No data available for Paralogs for LOC110121252 Gene

Variants for LOC110121252 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110121252 Gene

Disorders for LOC110121252 Gene

No disorders were found for LOC110121252 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110121252 Gene

Publications for LOC110121252 Gene

  1. Detection and characterization of silencers and enhancer-blockers in the greater CFTR locus. (PMID: 18436892) Petrykowska HM … Elnitski L (Genome research 2008) 3 54
  2. VISTA Enhancer Browser--a database of tissue-specific human enhancers. (PMID: 17130149) Visel A … Pennacchio LA (Nucleic acids research 2007) 3 54

No data available for Mastermind for LOC110121252 Gene

Products for LOC110121252 Gene

Sources for LOC110121252 Gene