This region represents the promoter of the bone gamma-carboxyglutamate protein (BGLAP) gene, which is also known as osteocalcin. This promoter is stimulated by vitamin D through binding of vitamin D receptor to a conserved recognition element. This element also mediates upregulation by vitamin A and repression by AP-1 family transcription factors, which compete for binding with... See more...

Aliases for LOC110013312 Gene

Aliases for LOC110013312 Gene

  • BGLAP Promoter Region 3
  • Osteocalcin Promoter 3

External Ids for LOC110013312 Gene

Summaries for LOC110013312 Gene

Entrez Gene Summary for LOC110013312 Gene

  • This region represents the promoter of the bone gamma-carboxyglutamate protein (BGLAP) gene, which is also known as osteocalcin. This promoter is stimulated by vitamin D through binding of vitamin D receptor to a conserved recognition element. This element also mediates upregulation by vitamin A and repression by AP-1 family transcription factors, which compete for binding with vitamin D receptor. Glucocorticoids act as negative regulators of activity through binding of nuclear receptor subfamily 3 group C member 1 (Nr3c1/Gr) to a recognition site that overlaps the TATA box, thereby inhibiting binding by TATA-box binding protein. Other regulators of this promoter include runt related transcription factor 2, cytokines, tumor necrosis factor, p53, and GATA repressor TRPS1. [provided by RefSeq, Apr 2017]

GeneCards Summary for LOC110013312 Gene

LOC110013312 (BGLAP Promoter Region) is a Biological Region gene.

Additional gene information for LOC110013312 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC110013312 Gene

Genomics for LOC110013312 Gene

Genomic Locations for LOC110013312 Gene

Genomic Locations for LOC110013312 Gene
chr1:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC110013312 Gene

RefSeq DNA sequence for LOC110013312 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC110013312 Gene

Proteins for LOC110013312 Gene

Post-translational modifications for LOC110013312 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC110013312 Gene

Domains & Families for LOC110013312 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC110013312 Gene

Function for LOC110013312 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC110013312 Gene

Localization for LOC110013312 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC110013312 Gene

Pathways & Interactions for LOC110013312 Gene

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SuperPathways for LOC110013312 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC110013312 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC110013312 Gene

Drugs & Compounds for LOC110013312 Gene

No Compound Related Data Available

Transcripts for LOC110013312 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC110013312 Gene

No ASD Table

No data available for mRNA/cDNA for LOC110013312 Gene

Expression for LOC110013312 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC110013312 Gene

Orthologs for LOC110013312 Gene

No data available for Orthologs and Evolution for LOC110013312 Gene

Paralogs for LOC110013312 Gene

No data available for Paralogs for LOC110013312 Gene

Variants for LOC110013312 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC110013312 Gene

Disorders for LOC110013312 Gene

No disorders were found for LOC110013312 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC110013312 Gene

Publications for LOC110013312 Gene

  1. Estrogen-related receptor alpha interacts cooperatively with peroxisome proliferator-activated receptor-gamma coactivator-1alpha to regulate osteocalcin gene expression. (PMID: 23788330) Wang H … Wang J (Cell biology international 2013) 3 54
  2. In vivo determination of vitamin d function using transgenic mice carrying a human osteocalcin luciferase reporter gene. (PMID: 23607098) Nakanishi T … Sato K (BioMed research international 2013) 3 54
  3. p53 and MDM2 are involved in the regulation of osteocalcin gene expression. (PMID: 22405968) Chen H … Chandar N (Experimental cell research 2012) 3 54
  4. Osteocalcin gene expression is regulated by wild-type p53. (PMID: 21964930) Chen H … Chandar N (Calcified tissue international 2011) 3 54
  5. A novel targeting modality for renal cell carcinoma: human osteocalcin promoter-mediated gene therapy synergistically induced by vitamin C and vitamin D₃. (PMID: 21105150) Johnson NA … Hsieh CL (The journal of gene medicine 2010) 3 54

No data available for Mastermind for LOC110013312 Gene

Products for LOC110013312 Gene

Sources for LOC110013312 Gene