External Ids for LOC110013312 Gene
- Entrez Gene: 110013312
This region represents the promoter of the bone gamma-carboxyglutamate protein (BGLAP) gene, which is also known as osteocalcin. This promoter is stimulated by vitamin D through binding of vitamin D receptor to a conserved recognition element. This element also mediates upregulation by vitamin A and repression by AP-1 family transcription factors, which compete for binding with vitamin D receptor. Glucocorticoids act as negative regulators of activity through binding of nuclear receptor subfamily 3 group C member 1 (Nr3c1/Gr) to a recognition site that overlaps the TATA box, thereby inhibiting binding by TATA-box binding protein. Other regulators of this promoter include runt related transcription factor 2, cytokines, tumor necrosis factor, p53, and GATA repressor TRPS1. [provided by RefSeq, Apr 2017]
GeneCards Summary for LOC110013312 Gene
LOC110013312 (BGLAP Promoter Region) is a Biological Region gene.