Aliases for LOC109280160 Gene
External Ids for LOC109280160 Gene
- Entrez Gene: 109280160
This biological region is known as FRA11B, and is found within the 5' untranslated region of the Cbl proto-oncogene (CBL) gene on the q arm of chromosome 11, and contains a CGG/CCG trinucleotide repeat. Somatic variability at this locus has been observed, and expansions of this repeat cause fragility at this folate-sensitive fragile site. Expansions resulting in repeats with a copy number of up to 800 have been observed. Experiments suggest that expansion of the trinucleotide repeat may cause hypermethylation of the DNA in this region. Chromosomal breakpoints in Jacobsen syndrome deletions have been mapped close to this region. [provided by RefSeq, Dec 2016]
GeneCards Summary for LOC109280160 Gene
LOC109280160 (FRA11B Repeat Instability Region) is a Biological Region gene. Diseases associated with LOC109280160 include Jacobsen Syndrome.