External Ids for LOC108961161 Gene
- Entrez Gene: 108961161
This region encompasses the proximal promoter and upstream regulatory elements of the POU class 5 homeobox 1 gene (POU5F1, commonly known as OCT3 or OCT4). It includes several regions that are highly conserved with the corresponding mouse region and may have similar activity. This promoter is induced by signalling through estrogen receptor and downregulated by aryl hydrocarbon. Activity of this sequence is regulated by binding of nuclear receptor family member proteins, including Nr5a1/Sf1 and Nr5a2/Lrh1, as well as ETS domain-containing transcription factors. This region is epigenetically silenced by DNA methylation during differentiation. [provided by RefSeq, Oct 2016]
GeneCards Summary for LOC108961161 Gene
LOC108961161 (POU5F1 5' Regulatory Region) is a Biological Region gene.