This region encompasses the proximal promoter and upstream regulatory elements of the POU class 5 homeobox 1 gene (POU5F1, commonly known as OCT3 or OCT4). It includes several regions that are highly conserved with the corresponding mouse region and may have similar activity. This promoter is induced by signalling through estrogen receptor and downregulated by aryl hydrocarbon.... See more...

Aliases for LOC108961161 Gene

Aliases for LOC108961161 Gene

  • POU5F1 5' Regulatory Region 3
  • OCT3/4 Promoter Region 3

External Ids for LOC108961161 Gene

Summaries for LOC108961161 Gene

Entrez Gene Summary for LOC108961161 Gene

  • This region encompasses the proximal promoter and upstream regulatory elements of the POU class 5 homeobox 1 gene (POU5F1, commonly known as OCT3 or OCT4). It includes several regions that are highly conserved with the corresponding mouse region and may have similar activity. This promoter is induced by signalling through estrogen receptor and downregulated by aryl hydrocarbon. Activity of this sequence is regulated by binding of nuclear receptor family member proteins, including Nr5a1/Sf1 and Nr5a2/Lrh1, as well as ETS domain-containing transcription factors. This region is epigenetically silenced by DNA methylation during differentiation. [provided by RefSeq, Oct 2016]

GeneCards Summary for LOC108961161 Gene

LOC108961161 (POU5F1 5' Regulatory Region) is a Biological Region gene.

Additional gene information for LOC108961161 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC108961161 Gene

Genomics for LOC108961161 Gene

Genomic Locations for LOC108961161 Gene

Genomic Locations for LOC108961161 Gene
chr6:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC108961161 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC108961161 Gene

Proteins for LOC108961161 Gene

Post-translational modifications for LOC108961161 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC108961161 Gene

Domains & Families for LOC108961161 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC108961161 Gene

Function for LOC108961161 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC108961161 Gene

Localization for LOC108961161 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC108961161 Gene

Pathways & Interactions for LOC108961161 Gene

PathCards logo

SuperPathways for LOC108961161 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC108961161 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC108961161 Gene

Drugs & Compounds for LOC108961161 Gene

No Compound Related Data Available

Transcripts for LOC108961161 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC108961161 Gene

No ASD Table

No data available for mRNA/cDNA for LOC108961161 Gene

Expression for LOC108961161 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC108961161 Gene

Orthologs for LOC108961161 Gene

No data available for Orthologs and Evolution for LOC108961161 Gene

Paralogs for LOC108961161 Gene

No data available for Paralogs for LOC108961161 Gene

Variants for LOC108961161 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC108961161 Gene

Disorders for LOC108961161 Gene

No disorders were found for LOC108961161 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC108961161 Gene

Publications for LOC108961161 Gene

  1. Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. (PMID: 26940070) Yong X … Yang SM (Cancer letters 2016) 3 54
  2. OCT4 is up-regulated by DNA hypomethylation of promoter in recurrent gliomas. (PMID: 26925786) Wu Y … Shi J (Neoplasma 2016) 3 54
  3. Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State. (PMID: 25858147) Chien CS … Chiou SH (Cancer research 2015) 3 54
  4. Identification of small activating RNAs that enhance endogenous OCT4 expression in human mesenchymal stem cells. (PMID: 25232932) Wang J … Li LC (Stem cells and development 2015) 3 54
  5. Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. (PMID: 26059097) Cheng J … Wang YJ (Nature communications 2015) 3 54

No data available for Mastermind for LOC108961161 Gene

Products for LOC108961161 Gene

Sources for LOC108961161 Gene