This region represents the proximal promoter, a potential upstream promoter, and associated 5' regulatory regions of the Nanog homeobox gene. These sequences include DNase I hypersensitive sites and multiple highly conserved regions, including a short conserved motif that is predicted to bind to POU class homeobox and SRY-box containing proteins (Oct/Sox box). Activity of this ... See more...

Aliases for LOC108942766 Gene

Aliases for LOC108942766 Gene

  • NANOG 5' Regulatory Region 3

External Ids for LOC108942766 Gene

Summaries for LOC108942766 Gene

Entrez Gene Summary for LOC108942766 Gene

  • This region represents the proximal promoter, a potential upstream promoter, and associated 5' regulatory regions of the Nanog homeobox gene. These sequences include DNase I hypersensitive sites and multiple highly conserved regions, including a short conserved motif that is predicted to bind to POU class homeobox and SRY-box containing proteins (Oct/Sox box). Activity of this promoter region is stimulated by Wnt/beta catenin, transforming growth factor beta, hypoxia, and androgen/androgen receptor, and may be inhibited by protein kinase C. This region may be epigenetically silenced by DNA cytosine methylation during differentiation. [provided by RefSeq, Oct 2016]

GeneCards Summary for LOC108942766 Gene

LOC108942766 (NANOG 5' Regulatory Region) is a Biological Region gene.

Additional gene information for LOC108942766 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC108942766 Gene

Genomics for LOC108942766 Gene

Genomic Locations for LOC108942766 Gene

Genomic Locations for LOC108942766 Gene
chr12:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC108942766 Gene

RefSeq DNA sequence for LOC108942766 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC108942766 Gene

Proteins for LOC108942766 Gene

Post-translational modifications for LOC108942766 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC108942766 Gene

Domains & Families for LOC108942766 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC108942766 Gene

Function for LOC108942766 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC108942766 Gene

Localization for LOC108942766 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC108942766 Gene

Pathways & Interactions for LOC108942766 Gene

PathCards logo

SuperPathways for LOC108942766 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC108942766 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC108942766 Gene

Drugs & Compounds for LOC108942766 Gene

No Compound Related Data Available

Transcripts for LOC108942766 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC108942766 Gene

No ASD Table

No data available for mRNA/cDNA for LOC108942766 Gene

Expression for LOC108942766 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC108942766 Gene

Orthologs for LOC108942766 Gene

No data available for Orthologs and Evolution for LOC108942766 Gene

Paralogs for LOC108942766 Gene

No data available for Paralogs for LOC108942766 Gene

Variants for LOC108942766 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC108942766 Gene

Disorders for LOC108942766 Gene

No disorders were found for LOC108942766 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC108942766 Gene

Publications for LOC108942766 Gene

  1. Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. (PMID: 26940070) Yong X … Yang SM (Cancer letters 2016) 3 54
  2. Androgen/androgen receptor axis maintains and promotes cancer cell stemness through direct activation of Nanog transcription in hepatocellular carcinoma. (PMID: 27167111) Jiang L … Liang Z (Oncotarget 2016) 3 54
  3. De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins. (PMID: 25724006) Squillaro T … Galderisi U (Cell cycle (Georgetown, Tex.) 2015) 3 54
  4. Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog. (PMID: 25348805) Paranjape AN … Rangarajan A (BMC cancer 2014) 3 54
  5. HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element. (PMID: 25271810) Petruzzelli R … Houghton FD (PloS one 2014) 3 54

No data available for Mastermind for LOC108942766 Gene

Products for LOC108942766 Gene

Sources for LOC108942766 Gene