This region is known to undergo non-allelic homologous recombination (NAHR) with another region, the AZFc P1.1 recombination region, located about 7.6 Mb centromere-distal of this region. NAHR between these regions can result in a deletion of the large intervening sequence, and is known as a P5/distal-P1 deletion, causing azoospermia. This region is contained within a very larg... See more...

Aliases for LOC108863624 Gene

Aliases for LOC108863624 Gene

  • AZFb P5.2 Recombination Region 3
  • Azoospermia Factor B Palindrome 5.2 Recombination Region 3

External Ids for LOC108863624 Gene

Summaries for LOC108863624 Gene

Entrez Gene Summary for LOC108863624 Gene

  • This region is known to undergo non-allelic homologous recombination (NAHR) with another region, the AZFc P1.1 recombination region, located about 7.6 Mb centromere-distal of this region. NAHR between these regions can result in a deletion of the large intervening sequence, and is known as a P5/distal-P1 deletion, causing azoospermia. This region is contained within a very large palindromic region known as P5 (palindrome 5). AZFa, AZFb, and AZFc have been defined as regions on chromosome Yq11, each containing multiple genes. Deletions in any of these regions can cause spermatogenic defects. NAHR between this region and the AZFc P1.1 recombination region removes the AZFb and part of the AZFc region. This region contains an NAHR exchange region identified in multiple individuals, and also contains a meiotic recombination hotspot. Nearby NAHR regions and non-homologous recombination exchange regions have also been identified. [provided by RefSeq, Oct 2016]

GeneCards Summary for LOC108863624 Gene

LOC108863624 (AZFb P5.2 Recombination Region) is a Biological Region gene. Diseases associated with LOC108863624 include Azoospermia.

Additional gene information for LOC108863624 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC108863624 Gene

Genomics for LOC108863624 Gene

Genomic Locations for LOC108863624 Gene

Genomic Locations for LOC108863624 Gene
chrY:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC108863624 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LOC108863624 Gene

No data available for GeneHancer (GH) Regulatory Elements for LOC108863624 Gene

Proteins for LOC108863624 Gene

Post-translational modifications for LOC108863624 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC108863624 Gene

Domains & Families for LOC108863624 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC108863624 Gene

Function for LOC108863624 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC108863624 Gene

Localization for LOC108863624 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC108863624 Gene

Pathways & Interactions for LOC108863624 Gene

PathCards logo

SuperPathways for LOC108863624 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for LOC108863624 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC108863624 Gene

Drugs & Compounds for LOC108863624 Gene

No Compound Related Data Available

Transcripts for LOC108863624 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC108863624 Gene

No ASD Table

No data available for mRNA/cDNA for LOC108863624 Gene

Expression for LOC108863624 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC108863624 Gene

Orthologs for LOC108863624 Gene

No data available for Orthologs and Evolution for LOC108863624 Gene

Paralogs for LOC108863624 Gene

No data available for Paralogs for LOC108863624 Gene

Variants for LOC108863624 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC108863624 Gene

Disorders for LOC108863624 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LOC108863624 Gene - From: GeneCards

Disorder Aliases PubMed IDs
azoospermia
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LOC108863624: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for LOC108863624 Gene

Publications for LOC108863624 Gene

  1. DNA recombination. Recombination initiation maps of individual human genomes. (PMID: 25395542) Pratto F … Camerini-Otero RD (Science (New York, N.Y.) 2014) 3 54
  2. AZF gene microdeletions: case series and literature review. (PMID: 24954841) Gallego A … Boronat F (Actas urologicas espanolas 2014) 3 54
  3. The frequency of Yq microdeletion in azoospermic and oligospermic Iranian infertile men. (PMID: 24639778) Zaimy MA … Zahraei M (Iranian journal of reproductive medicine 2013) 3 54
  4. The human Y chromosome's azoospermia factor b (AZFb) region: sequence, structure, and deletion analysis in infertile men. (PMID: 12525536) Ferlin A … Foresta C (Journal of medical genetics 2003) 3 54
  5. Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. (PMID: 12297986) Repping S … Rozen S (American journal of human genetics 2002) 3 54

No data available for Mastermind for LOC108863624 Gene

Products for LOC108863624 Gene

Sources for LOC108863624 Gene