This record encompasses the promoter and nearby elements that regulate expression of the steroidogenic acute regulatory protein (STAR) gene. Activity of this region is stimulated by cyclic AMP, and regulated through signalling by various factors, including angiotensin II, prostaglandin E2, and aryl hydrocarbons. The proximal promoter sequence is conserved in mammals and include... See more...

Aliases for LOC108863620 Gene

Aliases for LOC108863620 Gene

  • STAR 5' Regulatory Region 3

External Ids for LOC108863620 Gene

Summaries for LOC108863620 Gene

Entrez Gene Summary for LOC108863620 Gene

  • This record encompasses the promoter and nearby elements that regulate expression of the steroidogenic acute regulatory protein (STAR) gene. Activity of this region is stimulated by cyclic AMP, and regulated through signalling by various factors, including angiotensin II, prostaglandin E2, and aryl hydrocarbons. The proximal promoter sequence is conserved in mammals and includes recognition sites for nuclear receptor subfamily 5 group A member 1 (Nr5a1/Sf1), CCAAT/enhancer binding proteins, and sterol regulatory element binding transcription factor 1, which act as positive regulators of transcription. Nuclear receptor subfamily 0 group B member 1 (Nr0b1/Dax1) binds close to the putative TATA box and negatively regulates activity of this sequence. A distal regulatory region located approximately 3 kb from the transcription start site contains additional Nr5a1/Sf1 binding sites and was shown by chromatin conformation analysis to associate with the proximal promoter. [provided by RefSeq, Oct 2016]

GeneCards Summary for LOC108863620 Gene

LOC108863620 (STAR 5' Regulatory Region) is a Biological Region gene.

Additional gene information for LOC108863620 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LOC108863620 Gene

Genomics for LOC108863620 Gene

Genomic Locations for LOC108863620 Gene

Genomic Locations for LOC108863620 Gene
chr8:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for LOC108863620 Gene

RefSeq DNA sequence for LOC108863620 Gene

No data available for GeneHancer (GH) Regulatory Elements and Cytogenetic band for LOC108863620 Gene

Proteins for LOC108863620 Gene

Post-translational modifications for LOC108863620 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC108863620 Gene

Domains & Families for LOC108863620 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LOC108863620 Gene

Function for LOC108863620 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC108863620 Gene

Localization for LOC108863620 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LOC108863620 Gene

Pathways & Interactions for LOC108863620 Gene

PathCards logo

SuperPathways for LOC108863620 Gene

No Data Available
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Gene Ontology (GO) - Biological Process for LOC108863620 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LOC108863620 Gene

Drugs & Compounds for LOC108863620 Gene

No Compound Related Data Available

Transcripts for LOC108863620 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LOC108863620 Gene

No ASD Table

No data available for mRNA/cDNA for LOC108863620 Gene

Expression for LOC108863620 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC108863620 Gene

Orthologs for LOC108863620 Gene

No data available for Orthologs and Evolution for LOC108863620 Gene

Paralogs for LOC108863620 Gene

No data available for Paralogs for LOC108863620 Gene

Variants for LOC108863620 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LOC108863620 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs567801443 Uncertain Significance: Congenital adrenal hyperplasia 38,151,073( ) C/A
rs886062906 Uncertain Significance: Congenital adrenal hyperplasia 38,151,067( ) G/T

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC108863620 Gene

Disorders for LOC108863620 Gene

No disorders were found for LOC108863620 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC108863620 Gene

Publications for LOC108863620 Gene

  1. C/EBPβ (CCAAT/enhancer-binding protein β) mediates progesterone production through transcriptional regulation in co-operation with SF-1 (steroidogenic factor-1). (PMID: 24635384) Mizutani T … Miyamoto K (The Biochemical journal 2014) 3 54
  2. Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation. (PMID: 24823468) Xu JN … Xue Q (The Journal of clinical endocrinology and metabolism 2014) 3 54
  3. Angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1. (PMID: 22253417) Meier RK … Clark BJ (Endocrinology 2012) 3 54
  4. Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells. (PMID: 21350237) Martin LJ … Tremblay JJ (Journal of andrology 2012) 3 54
  5. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells. (PMID: 22100783) Ping J … Wang H (Chemico-biological interactions 2012) 3 54

No data available for Mastermind for LOC108863620 Gene

Products for LOC108863620 Gene

Sources for LOC108863620 Gene