Aliases for LOC108783653 Gene
External Ids for LOC108783653 Gene
- Entrez Gene: 108783653
This region is known to undergo non-allelic homologous recombination (NAHR) with another recombination region, the SUZ12P1 PRS4 recombination region, which is located a little over 1.2 Mb centromere-proximal to this region. NAHR between the SUZ12P1 PRS4 and the SUZ12 PRS4 recombination regions can result in deletions of the intervening sequences, including the neurofibromin 1 (NF1) gene, and is known as a type-2 NF1 deletion, causing neurofibromatosis type 1 (NF1), an autosomal dominant disorder. Unlike other NF1 deletions, type-2 deletions are thought to predominantly occur from mitotic intrachromosomal recombination, since somatic mosaicism is observed in most individuals. This region contains multiple sub-regions, corresponding to different crossover regions. Crossovers both proximal and distal to this region have also been identified in some individuals with type-2 NF1 deletions. [provided by RefSeq, Sep 2016]
GeneCards Summary for LOC108783653 Gene
LOC108783653 (SUZ12 PRS4 Recombination Region) is a Biological Region gene.