Aliases for LOC108281159 Gene
External Ids for LOC108281159 Gene
- Entrez Gene: 108281159
This region is found within an intron of the neurofibromin 1 (NF1) gene on the q arm of chromosome 17, and is known to undergo recombination, forming either translocations or deletions. This region contains a palindromic AT-rich repeat (PATRR) known as PATRR17, and is highly polymorphic. Both long and short versions of the palindromic region have been identified, and are known as 17-L-PATRR and 17-S-PATRR for the long and short versions, respectively. The majority of DNA breaks are thought to form in the loop region of the stem loop. Recombination with another palindromic region found on chromosome 22 (PATRR22) can result in translocation events. Recombination with sequences within the NF1 gene have also been observed, resulting in deletions. Both the translocation and deletion events disrupt the NF1 gene, resulting in neurofibromatosis, a tumor disorder characterized by cafe au lait spots, neurofibromas, and Lisch nodules. Recombination breakpoints from different individuals are reported as breakpoint sub-regions on the record. [provided by RefSeq, Jul 2016]
GeneCards Summary for LOC108281159 Gene
LOC108281159 (PATRR17 Recombination Region) is a Biological Region gene.