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Aliases for LOC102723996 Gene

Aliases for LOC102723996 Gene

  • ICOS Ligand 3
  • Homo Sapiens ICOS Ligand (LOC102723996), MRNA. 5
  • Uncharacterized Protein 13
  • FP565260.3 5

External Ids for LOC102723996 Gene

Previous GeneCards Identifiers for LOC102723996 Gene

  • GC21U900540

Summaries for LOC102723996 Gene

GeneCards Summary for LOC102723996 Gene

LOC102723996 (ICOS Ligand) is a Protein Coding gene. Among its related pathways are Innate Immune System and CD28 co-stimulation. An important paralog of this gene is ICOSLG.

Additional gene information for LOC102723996 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC102723996 Gene

Genomics for LOC102723996 Gene

GeneHancer (GH) Regulatory Elements for LOC102723996 Gene

Promoters and enhancers for LOC102723996 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J005020 Promoter 0.5 Ensembl 600.7 -0.4 -443 4.8 LOC102723996 LOC105379484
GH21J005024 Promoter 0.5 Ensembl 0.7 +2.3 2257 0.2 LOC102723996 CH507-9B2.8
GH21J005040 Enhancer 0.2 Ensembl 0.3 +20.6 20556 6 LOC102723996 CH507-9B2.8
GH21J005047 Enhancer 0.2 Ensembl 0.3 +26.1 26057 1.4 CH507-9B2.8 LOC102723996
GH21J005050 Enhancer 0.2 Ensembl 0.3 +29.5 29456 2.2 CH507-9B2.8 LOC102723996
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LOC102723996 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LOC102723996 Gene

Genomic Locations for LOC102723996 Gene
chr21:5,022,044-5,046,692
(GRCh38/hg38)
Size:
24,649 bases
Orientation:
Plus strand

Genomic View for LOC102723996 Gene

Genes around LOC102723996 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOC102723996 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOC102723996 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOC102723996 Gene

Proteins for LOC102723996 Gene

  • Protein details for LOC102723996 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087X1L8-A0A087X1L8_HUMAN
    Recommended name:
    Uncharacterized protein
    Protein Accession:
    A0A087X1L8

    Protein attributes for LOC102723996 Gene

    Size:
    192 amino acids
    Molecular mass:
    20996 Da
    Quaternary structure:
    No Data Available
  • Protein details for LOC102723996 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A096LPE5-A0A096LPE5_HUMAN
    Recommended name:
    Uncharacterized protein
    Protein Accession:
    A0A096LPE5

    Protein attributes for LOC102723996 Gene

    Size:
    77 amino acids
    Molecular mass:
    8167 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LOC102723996 Gene

Post-translational modifications for LOC102723996 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LOC102723996 Gene

Domains & Families for LOC102723996 Gene

Protein Domains for LOC102723996 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LOC102723996: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LOC102723996 Gene

Function for LOC102723996 Gene

Phenotypes for LOC102723996 Gene

genes like me logo Genes that share phenotypes with LOC102723996: view

Animal Models for LOC102723996 Gene

MGI Knock Outs for LOC102723996:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LOC102723996 Gene

Localization for LOC102723996 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytoplasmic bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LOC102723996 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with LOC102723996: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for LOC102723996 Gene

Pathways & Interactions for LOC102723996 Gene

genes like me logo Genes that share pathways with LOC102723996: view

Pathways by source for LOC102723996 Gene

Interacting Proteins for LOC102723996 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000483732%0d9606.ENSP00000303939%0d9606.ENSP00000319476%0d9606.ENSP00000324890%0d
Selected Interacting proteins: ENSP00000483732 for LOC102723996 Gene via STRING

GPS-Prot Interaction Network for LOC102723996

Gene Ontology (GO) - Biological Process for LOC102723996 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0007165 signal transduction IBA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0031295 T cell costimulation IBA --
GO:0042102 positive regulation of T cell proliferation IBA --
genes like me logo Genes that share ontologies with LOC102723996: view

No data available for SIGNOR curated interactions for LOC102723996 Gene

Drugs & Compounds for LOC102723996 Gene

No Compound Related Data Available

Transcripts for LOC102723996 Gene

mRNA/cDNA for LOC102723996 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LOC102723996 Gene

No ASD Table

Relevant External Links for LOC102723996 Gene

GeneLoc Exon Structure for
LOC102723996

Expression for LOC102723996 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC102723996 Gene

Orthologs for LOC102723996 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LOC102723996 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICOSLG 34
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia ICOSLG 34
  • 73.5 (n)
cow
(Bos Taurus)
Mammalia ICOSLG 34
  • 73.06 (n)
rat
(Rattus norvegicus)
Mammalia Icoslg 34
  • 63.04 (n)
mouse
(Mus musculus)
Mammalia Icosl 17 34
  • 61.58 (n)
chicken
(Gallus gallus)
Aves ICOSLG 34
  • 47.51 (n)
Species where no ortholog for LOC102723996 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LOC102723996 Gene

ENSEMBL:
Gene Tree for LOC102723996 (if available)
TreeFam:
Gene Tree for LOC102723996 (if available)

Paralogs for LOC102723996 Gene

genes like me logo Genes that share paralogs with LOC102723996: view

Variants for LOC102723996 Gene

Sequence variations from dbSNP and Humsavar for LOC102723996 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1156260023 -- 5,035,251(+) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1156575273 -- 5,034,097(+) A/G 3_prime_UTR_variant, intron_variant
rs1156582960 -- 5,031,951(+) T/C intron_variant
rs1156635115 -- 5,033,272(+) T/A intron_variant
rs1156940977 -- 5,031,123(+) A/ intron_variant

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for LOC102723996 Gene

Disorders for LOC102723996 Gene

No disorders were found for LOC102723996 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC102723996 Gene

Publications for LOC102723996 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 13 58

No data available for External Links for LOC102723996 Gene

Products for LOC102723996 Gene

Sources for LOC102723996 Gene

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