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Aliases for LOC100133315 Gene

Aliases for LOC100133315 Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 2-Like 3
  • Putative Short Transient Receptor Potential Channel 2-Like Protein 5
  • TrpC2-Like Protein 4
  • AP002495.1 5

External Ids for LOC100133315 Gene

Previous GeneCards Identifiers for LOC100133315 Gene

  • GC11U900991
  • GC11M071254
  • GC11M071576

Summaries for LOC100133315 Gene

GeneCards Summary for LOC100133315 Gene

LOC100133315 (Transient Receptor Potential Cation Channel, Subfamily C, Member 2-Like) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include calmodulin binding and store-operated calcium channel activity. An important paralog of this gene is XRCC1.

Additional gene information for LOC100133315 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC100133315 Gene

Genomics for LOC100133315 Gene

GeneHancer (GH) Regulatory Elements for LOC100133315 Gene

Promoters and enhancers for LOC100133315 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I071927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.2 -1180 5.5 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 RNF121 LOC100133315 NUMA1 LOC100128494 NADSYN1 ZNF705E IL18BP FAM86C1 ENSG00000255843 LRTOMT
GH11I071995 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.4 -69.9 -69856 5.1 PKNOX1 ARNT TCF12 ATF7 NCOA1 REST ZNF592 MBD2 SMARCA4 ZNF184 IL18BP LRTOMT LOC100133315 RNF121 LAMTOR1 ANAPC15 FAM86C1 GC11P072002
GH11I071962 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.3 -34.3 -34290 1.6 BMI1 BATF IRF4 ATF7 IKZF2 RUNX3 CEBPB JUNB ZNF217 SP1 LOC100133315 RNF121 LOC100128494 NUMA1 LRTOMT ANAPC15 LAMTOR1 PHOX2A FAM86C1 PIR62264
GH11I071991 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 -63.0 -63022 1.3 PKNOX1 SMAD1 BACH1 BMI1 BATF KLF5 IRF4 YY1 ATF7 ETV6 FOLR3 LRTOMT NUMA1 RNF121 LOC100133315 PHOX2A OR7E128P IL18BP PIR62264
GH11I072001 Enhancer 0.9 ENCODE dbSUPER 10.2 -73.9 -73889 2 ESRRA SMAD5 SUZ12 ZNF10 USF2 GATAD2B POLR2B ZNF512B E2F8 POLR2A GC11P072002 LRTOMT LOC100133315 RNF121 LAMTOR1 ANAPC15 LOC100128494 IL18BP PIR48136 NUMA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LOC100133315 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LOC100133315 gene promoter:

Genomic Locations for LOC100133315 Gene

Genomic Locations for LOC100133315 Gene
chr11:71,865,509-71,928,654
(GRCh38/hg38)
Size:
63,146 bases
Orientation:
Minus strand
chr11:71,576,555-71,639,700
(GRCh37/hg19)

Genomic View for LOC100133315 Gene

Genes around LOC100133315 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOC100133315 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOC100133315 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOC100133315 Gene

Proteins for LOC100133315 Gene

  • Protein details for LOC100133315 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNB5-TRC2L_HUMAN
    Recommended name:
    Putative short transient receptor potential channel 2-like protein
    Protein Accession:
    Q6ZNB5

    Protein attributes for LOC100133315 Gene

    Size:
    142 amino acids
    Molecular mass:
    15763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LOC100133315 Gene

Post-translational modifications for LOC100133315 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LOC100133315 Gene

No data available for DME Specific Peptides for LOC100133315 Gene

Domains & Families for LOC100133315 Gene

Protein Domains for LOC100133315 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNB5

UniProtKB/Swiss-Prot:

TRC2L_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
genes like me logo Genes that share domains with LOC100133315: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for LOC100133315 Gene

Function for LOC100133315 Gene

Gene Ontology (GO) - Molecular Function for LOC100133315 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IEA --
genes like me logo Genes that share ontologies with LOC100133315: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC100133315 Gene

Localization for LOC100133315 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LOC100133315 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LOC100133315 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LOC100133315: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LOC100133315 Gene

Pathways & Interactions for LOC100133315 Gene

SuperPathways for LOC100133315 Gene

No Data Available

Interacting Proteins for LOC100133315 Gene

Gene Ontology (GO) - Biological Process for LOC100133315 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000012 single strand break repair IEA --
GO:0006284 base-excision repair IBA --
genes like me logo Genes that share ontologies with LOC100133315: view

No data available for Pathways by source and SIGNOR curated interactions for LOC100133315 Gene

Drugs & Compounds for LOC100133315 Gene

No Compound Related Data Available

Transcripts for LOC100133315 Gene

mRNA/cDNA for LOC100133315 Gene

(2) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LOC100133315 Gene

Transient receptor potential cation channel, subfamily C, member 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LOC100133315 Gene

No ASD Table

Relevant External Links for LOC100133315 Gene

GeneLoc Exon Structure for
LOC100133315

Expression for LOC100133315 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LOC100133315 Gene

SOURCE GeneReport for Unigene cluster for LOC100133315 Gene:

Hs.150324
genes like me logo Genes that share expression patterns with LOC100133315: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC100133315 Gene

Orthologs for LOC100133315 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOC100133315 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:110224 34
  • 20 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta XRCC1 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 10 (a)
OneToMany
Species where no ortholog for LOC100133315 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LOC100133315 Gene

ENSEMBL:
Gene Tree for LOC100133315 (if available)
TreeFam:
Gene Tree for LOC100133315 (if available)

Paralogs for LOC100133315 Gene

Paralogs for LOC100133315 Gene

genes like me logo Genes that share paralogs with LOC100133315: view

Variants for LOC100133315 Gene

Sequence variations from dbSNP and Humsavar for LOC100133315 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010351 -- 71,895,947(-) C/G intron_variant
rs1000019769 -- 71,865,328(-) T/G downstream_transcript_variant
rs1000039173 -- 71,887,069(-) G/C intron_variant
rs1000087499 -- 71,899,944(-) T/C intron_variant
rs1000121397 -- 71,910,949(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LOC100133315 Gene

Variant ID Type Subtype PubMed ID
dgv223e199 CNV deletion 23128226
esv25167 CNV gain 19812545
esv2744758 CNV deletion 23290073
esv2744760 CNV deletion 23290073
esv2759836 CNV gain+loss 17122850
esv2761682 CNV gain 21179565
esv3390531 CNV insertion 20981092
esv3626788 CNV loss 21293372
esv3626789 CNV gain 21293372
nsv1122643 CNV deletion 24896259
nsv383 CNV insertion 18451855
nsv428262 CNV gain+loss 18775914
nsv509428 CNV insertion 20534489
nsv972041 CNV duplication 23825009
nsv976011 CNV duplication 23825009

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Additional Variant Information for LOC100133315 Gene

Disorders for LOC100133315 Gene

Additional Disease Information for LOC100133315

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LOC100133315 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LOC100133315 Gene

Publications for LOC100133315 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Characterization of TRPC2, an essential genetic component of VNS chemoreception, provides insights into the evolution of pheromonal olfaction in secondary-adapted marine mammals. (PMID: 20142439) Yu L … Zhang YP (Molecular biology and evolution 2010) 3 58
  3. TRPC2: molecular biology and functional importance. (PMID: 17217050) Yildirim E … Birnbaumer L (Handbook of experimental pharmacology 2007) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for LOC100133315 Gene

Sources for LOC100133315 Gene

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