Aliases for LNX1 Gene
Aliases for LNX1 Gene
External Ids for LNX1 Gene
- HGNC: 6657
- Entrez Gene: 84708
- Ensembl: ENSG00000072201
- OMIM: 609732
- UniProtKB: Q8TBB1
Previous HGNC Symbols for LNX1 Gene
- LNX
Previous GeneCards Identifiers for LNX1 Gene
- GC04M054167
- GC04M054020
- GC04M054325
- GC04M050271
Summaries for LNX1 Gene
-
This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LNX1 Gene
LNX1 (Ligand Of Numb-Protein X 1) is a Protein Coding gene. Diseases associated with LNX1 include Usher Syndrome and Autoimmune Enteropathy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and PDZ domain binding. An important paralog of this gene is LNX2.
UniProtKB/Swiss-Prot for LNX1 Gene
-
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
-
Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
Additional gene information for LNX1 Gene
- Monarch Initiative
- Search for LNX1 at DataMed
- Search for LNX1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNX1 Gene
Genomics for LNX1 Gene
GeneHancer (GH) Regulatory Elements for LNX1 Gene
Promoters and enhancers for LNX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LNX1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LNX1 gene promoter:
-
- E2F-3a
- Lmo2
- ARP-1
- E2F-5
- E2F-4
- Roaz
- E2F-2
- E2F-1
- E2F
- RFX1
Regulatory Element Products
Genomic Locations for LNX1 Gene
Genomic Locations for LNX1 Gene
- chr4:53,459,301-53,701,405
- (GRCh38/hg38)
- Size:
- 242,105 bases
- Orientation:
- Minus strand
- chr4:54,325,468-54,567,572
- (GRCh37/hg19)
- Size:
- 242,105 bases
- Orientation:
- Minus strand
Genomic View for LNX1 Gene
Genes around LNX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q12 by Entrez Gene
- 4q12 by HGNC
- 4q12 by Ensembl
LNX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LNX1 Gene
Proteins for LNX1 Gene
-
Protein details for LNX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TBB1-LNX1_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase LNX
- Protein Accession:
- Q8TBB1
- Q4W5K7
- Q8N4C2
- Q96MJ7
- Q9BY20
Protein attributes for LNX1 Gene
- Size:
- 728 amino acids
- Molecular mass:
- 80629 Da
- Quaternary structure:
-
- Interacts with the phosphotyrosine interaction domain of all isoforms of NUMB (By similarity). Interacts with MAGEB18 and MAGEF1. Interacts with the Coxsackievirus and adenovirus receptor CXADR. Interacts with endogenous retrovirus K protein Np9. IGSF5/JAM4 interacts with isoform 2 through the second PDZ domain, other isoforms may also interact with IGSF5/JAM4 (By similarity).
Protein Expression for LNX1 Gene
Post-translational modifications for LNX1 Gene
Other Protein References for LNX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LNX1
- Novus Biologicals Antibodies for LNX1
-
Abcam antibodies for LNX1
- Invitrogen Antibodies for LNX1
- GeneTex LNX1 Antibody for LNX1
Protein Products
-
OriGene Purified Proteins for LNX1
- Search Origene for MassSpec and Protein Over-expression Lysates for LNX1
- Origene Custom Protein Services for LNX1
- antibodies-online: Search results for 4 available LNX1 Proteins ranked by validation data
- Compare Top LNX1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for LNX1
-
Abcam proteins for LNX1
Assay Products
- antibodies-online: Search results for 2 available LNX1 Elisa Kits ranked by validation data
- Compare Top LNX1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for LNX1 Gene
Domains & Families for LNX1 Gene
Gene Families for LNX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for LNX1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LNX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TBB1UniProtKB/Swiss-Prot:
LNX1_HUMAN :- The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.
- Domain:
-
- The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.
- The PDZ 1 domain participates in the interaction with the PID domain of NUMB, and participates in the isoform-specific ubiquitination of NUMB. The PDZ 2 domain of isoform 2 participates in the interaction with IGSF5/JAM4, other isoforms containing this domain may also interact with IGSF5/JAM4 (By similarity).
Function for LNX1 Gene
Molecular function for LNX1 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
- UniProtKB/Swiss-Prot Function:
- Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Enzyme Numbers (IUBMB) for LNX1 Gene
Phenotypes From GWAS Catalog for LNX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16002321 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0030165 | PDZ domain binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for LNX1 Gene
- MGI mutant phenotypes for LNX1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LNX1:
Animal Models for LNX1 Gene
- MGI Knock Outs for LNX1:
-
- Lnx1 Lnx1<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for LNX1
- Cyagen custom Knockout/knockin (KOKI) mouse models for LNX1
-
CRISPR Products
-
OriGene CRISPR knockouts for LNX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LNX1
- genomics-online: gRNA clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- Applied Biological Materials CRISPR for LNX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LNX1
- GenScript: Design CRISPR guide RNA sequences for LNX1
miRNA for LNX1 Gene
- miRTarBase miRNAs that target LNX1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LNX1
- Browse OriGene Inhibitory RNA Products For LNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LNX1
- genomics-online: shRNA clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LNX1
- VectorBuilder custom plasmid, inducible vectors for LNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LNX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LNX1
- Applied Biological Materials Clones for LNX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LNX1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LNX1 Gene
Localization for LNX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LNX1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| cytoskeleton | 1 |
- Cell Junctions (3)
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for LNX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Notch signaling pathway (KEGG) | ||
Pathways by source for LNX1 Gene
1 BioSystems pathway for LNX1 Gene
UniProtKB/Swiss-Prot Q8TBB1-LNX1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for LNX1 Gene
Selected Interacting proteins:
Q8TBB1-LNX1_HUMAN
ENSP00000263925
for LNX1 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for LNX1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0051260 | protein homooligomerization | IEA | -- |
Drugs & Compounds for LNX1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for LNX1 Gene
mRNA/cDNA for LNX1 Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000306888 3757 bps (uc003haf.5)
- ENST00000263925 2953 bps (uc003hag.6)
- ENST00000511398 622 bps (uc062wpw.1)
- ENST00000513421 1024 bps (uc062wpz.1)
- ENST00000510143 731 bps (uc062wqa.1)
Unigene Clusters for LNX1 Gene
- Ligand of numb-protein X 1, E3 ubiquitin protein ligase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LNX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LNX1
- genomics-online: gRNA clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- Applied Biological Materials CRISPR for LNX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LNX1
- GenScript: Design CRISPR guide RNA sequences for LNX1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LNX1
- Browse OriGene Inhibitory RNA Products For LNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LNX1
- genomics-online: shRNA clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for LNX1
- VectorBuilder custom plasmid, inducible vectors for LNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LNX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LNX1
- Applied Biological Materials Clones for LNX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: |
Expression for LNX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
mRNA differential expression in normal tissues according to GTEx for LNX1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.1).
This gene is overexpressed in Cervix (49.8) and Adipocyte (13.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LNX1 Gene
NURSA nuclear receptor signaling pathways regulating expression of LNX1 Gene:
LNX1SOURCE GeneReport for Unigene cluster for LNX1 Gene:
Hs.518760mRNA Expression by UniProt/SwissProt for LNX1 Gene:
Q8TBB1-LNX1_HUMAN
Tissue specificity:
Expressed in heart, placenta, kidney, pancreas and brain.
Evidence on tissue expression from TISSUES for LNX1 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs and template standards for LNX1
-
OriGene qPCR primer pairs for LNX1
- genomics-online: primer clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LNX1 Gene
Orthologs for LNX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LNX1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LNX1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LNX1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Lnx1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Lnx1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LNX1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | LNX1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | LNX1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lnx1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lnx1 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | inaD 34 |
|
OneToMany |
- Species where no ortholog for LNX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for LNX1 Gene
- ENSEMBL:
- Gene Tree for LNX1 (if available)
- TreeFam:
- Gene Tree for LNX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LNX1: view image
Paralogs for LNX1 Gene
(10) SIMAP similar genes for LNX1 Gene using alignment to 4 proteins:
- LNX1_HUMAN
- D6RAH9_HUMAN
- D6RB76_HUMAN
- D6RE08_HUMAN
Pseudogenes.org Pseudogenes for LNX1 Gene
Variants for LNX1 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010609 | -- | 53,584,896(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000023650 | -- | 53,626,087(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs10000315 | -- | 53,570,427(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs10000457 | -- | 53,555,372(-) | C/T | intron_variant | |
| rs1000047807 | -- | 53,507,149(-) | T/ | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv829936 | CNV | gain | 17160897 |
| nsv516916 | CNV | loss | 19592680 |
| nsv476884 | CNV | novel sequence insertion | 20440878 |
| nsv437918 | CNV | loss | 16468122 |
| nsv1146065 | CNV | duplication | 26484159 |
| nsv1115671 | CNV | duplication | 24896259 |
| esv3600527 | CNV | loss | 21293372 |
| esv3379648 | CNV | insertion | 20981092 |
| esv3339869 | CNV | insertion | 20981092 |
| esv3331791 | CNV | duplication | 20981092 |
| esv3309918 | CNV | mobile element insertion | 20981092 |
| esv3307826 | CNV | mobile element insertion | 20981092 |
| esv3303852 | CNV | mobile element insertion | 20981092 |
| esv28169 | CNV | gain | 19812545 |
| esv1673226 | CNV | insertion | 17803354 |
Residual Variation Intolerance Score:
49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.27;
40.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LNX1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LNX1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LNX1 Gene
Disorders for LNX1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| usher syndrome |
|
|
| autoimmune enteropathy |
|
|
Search LNX1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LNX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LNX1 Gene
Publications for LNX1 Gene
- Identification of a human LNX protein containing multiple PDZ domains. (PMID: 11521506) Xie Y … Mao Y (Biochemical genetics 2001) 2 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 58
- A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D … International Kawasaki Disease Genetics Consortium (PLoS genetics 2009) 3 44 58
- Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors. (PMID: 18940473) Blom T … Nupponen NN (Cancer genetics and cytogenetics 2008) 3 44 58
Products for LNX1 Gene
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- Taconic Biosciences Mouse Models for LNX1
- Find your next knockout model in the Taconic Knockout Repository
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LNX1
- antibodies-online: Search results for 51 available LNX1 Antibodies ranked by validation data
- Compare Top LNX1 Antibodies
- antibodies-online: Search results for 2 available LNX1 Elisa Kits ranked by validation data
- Compare Top LNX1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available LNX1 Proteins ranked by validation data
- Compare Top LNX1 Proteins
- Quality Products:
- genomics-online: cdna clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- orf clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- genomics-online: gRNA clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- genomics-online: primer clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- genomics-online: shRNA clones - Search results for 156 available LNX1 gene related products
- Overview of 156 available LNX1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LNX1
- GeneCopoeia miRNA 3'UTR Target clone products for LNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LNX1
Sources for LNX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt