Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LNP1 Gene

Aliases for LNP1 Gene

  • Leukemia NUP98 Fusion Partner 1 2 3 3 5
  • NP3 3 4

External Ids for LNP1 Gene

Previous GeneCards Identifiers for LNP1 Gene

  • GC00U921682
  • GC03P101603
  • GC03P100120
  • GC03P097487

Summaries for LNP1 Gene

GeneCards Summary for LNP1 Gene

LNP1 (Leukemia NUP98 Fusion Partner 1) is a Protein Coding gene.

Additional gene information for LNP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNP1 Gene

Genomics for LNP1 Gene

GeneHancer (GH) Regulatory Elements for LNP1 Gene

Promoters and enhancers for LNP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J100399 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 670.8 +0.6 647 4.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 POLR2B LNP1 TOMM70 PIR48705 TBC1D23 TFG GC03P100464
GH03J100333 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.3 -65.8 -65798 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 NIT2 LNP1 TOMM70 TBC1D23
GH03J100707 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8.2 +308.2 308155 4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B TFG LNP1 GC03M100717
GH03J100395 Enhancer 0.6 ENCODE 20.8 -4.9 -4909 1.8 JUNB CEBPB CEBPG BATF RAD21 GABPA FOXA1 SP1 CEBPA HNF4A LNP1 TOMM70 NIT2
GH03J100590 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 +189.5 189487 0.6 ELF3 CTCF CEBPG RAD21 RFX5 ZNF366 ZNF143 SMC3 ZNF444 BCLAF1 GC03P100589 LNP1 TOMM70 TMEM45A ADGRG7 GC03M100588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LNP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LNP1 gene promoter:
  • p53
  • FOXD1
  • YY1
  • Cdc5
  • STAT5A
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • CHOP-10

Genomic Locations for LNP1 Gene

Genomic Locations for LNP1 Gene
chr3:100,401,193-100,456,326
(GRCh38/hg38)
Size:
55,134 bases
Orientation:
Plus strand
chr3:100,120,037-100,175,170
(GRCh37/hg19)
Size:
55,134 bases
Orientation:
Plus strand

Genomic View for LNP1 Gene

Genes around LNP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LNP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LNP1 Gene

Proteins for LNP1 Gene

  • Protein details for LNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4G5-LNP1_HUMAN
    Recommended name:
    Leukemia NUP98 fusion partner 1
    Protein Accession:
    A1A4G5
    Secondary Accessions:
    • B7ZLT3

    Protein attributes for LNP1 Gene

    Size:
    178 amino acids
    Molecular mass:
    21321 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LNP1 Gene

Post-translational modifications for LNP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LNP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LNP1 Gene

Domains & Families for LNP1 Gene

Gene Families for LNP1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for LNP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LNP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LNP1: view

No data available for UniProtKB/Swiss-Prot for LNP1 Gene

Function for LNP1 Gene

genes like me logo Genes that share phenotypes with LNP1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LNP1 Gene

Localization for LNP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LNP1 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LNP1 Gene

Pathways & Interactions for LNP1 Gene

No Data Available

Interacting Proteins for LNP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373191%0d%0a9606.ENSP00000380998%0d%0a9606.ENSP00000376333%0d%0a
Selected Interacting proteins: ENSP00000373191 A1A4G5-LNP1_HUMAN for LNP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for LNP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LNP1 Gene

Drugs & Compounds for LNP1 Gene

No Compound Related Data Available

Transcripts for LNP1 Gene

mRNA/cDNA for LNP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(92) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LNP1 Gene

Leukemia NUP98 fusion partner 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LNP1 Gene

No ASD Table

Relevant External Links for LNP1 Gene

GeneLoc Exon Structure for
LNP1
ECgene alternative splicing isoforms for
LNP1

Expression for LNP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LNP1 Gene

mRNA differential expression in normal tissues according to GTEx for LNP1 Gene

This gene is overexpressed in Testis (x4.4).

Protein differential expression in normal tissues from HIPED for LNP1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LNP1 Gene



Protein tissue co-expression partners for LNP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LNP1 Gene:

LNP1

SOURCE GeneReport for Unigene cluster for LNP1 Gene:

Hs.591294

Evidence on tissue expression from TISSUES for LNP1 Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with LNP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LNP1 Gene

Orthologs for LNP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LNP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LNP1 34 33
  • 99.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LNP1 34 33
  • 85.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LNP1 34 33
  • 84.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lnp1 33
  • 77.97 (n)
mouse
(Mus musculus)
Mammalia Gm19797 33
  • 76.7 (n)
Lnp1 16
oppossum
(Monodelphis domestica)
Mammalia LNP1 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LNP1 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves LNP1 34
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LNP1 34
  • 37 (a)
OneToOne
Species where no ortholog for LNP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LNP1 Gene

ENSEMBL:
Gene Tree for LNP1 (if available)
TreeFam:
Gene Tree for LNP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LNP1: view image

Paralogs for LNP1 Gene

Pseudogenes.org Pseudogenes for LNP1 Gene

genes like me logo Genes that share paralogs with LNP1: view

No data available for Paralogs for LNP1 Gene

Variants for LNP1 Gene

Sequence variations from dbSNP and Humsavar for LNP1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000095939 -- 100,434,807(+) G/A intron_variant
rs1000150043 -- 100,409,057(+) G/A intron_variant
rs1000166356 -- 100,421,439(+) C/A intron_variant
rs1000269038 -- 100,426,762(+) C/T intron_variant
rs1000315594 -- 100,447,036(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LNP1 Gene

Variant ID Type Subtype PubMed ID
esv3329674 CNV insertion 20981092
esv1330906 CNV insertion 17803354

Variation tolerance for LNP1 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LNP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LNP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LNP1 Gene

Disorders for LNP1 Gene

UniProtKB/Swiss-Prot

LNP1_HUMAN
  • Note=A chromosomal aberration involving LNP1 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with NUP98. {ECO:0000269 PubMed:16467868}.

Additional Disease Information for LNP1

No disorders were found for LNP1 Gene.

No data available for MalaCards and Genatlas for LNP1 Gene

Publications for LNP1 Gene

  1. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique. (PMID: 16467868) Romana SP … Groupe Francophone de Cytogénétique Hématologique (Leukemia 2006) 2 3 4 58
  2. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J … Elledge SJ (Nature biotechnology 2013) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for LNP1 Gene

Sources for LNP1 Gene

Content
Loading form....