Aliases for LMTK3 Gene
External Ids for LMTK3 Gene
Previous GeneCards Identifiers for LMTK3 Gene
GeneCards Summary for LMTK3 Gene
LMTK3 (Lemur Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with LMTK3 include Breast Cancer. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.
UniProtKB/Swiss-Prot Summary for LMTK3 Gene
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).