Aliases for LMTK3 Gene
External Ids for LMTK3 Gene
Previous GeneCards Identifiers for LMTK3 Gene
GeneCards Summary for LMTK3 Gene
LMTK3 (Lemur Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with LMTK3 include Breast Cancer. Among its related pathways are Activation of cAMP-Dependent PKA and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.
UniProtKB/Swiss-Prot Summary for LMTK3 Gene
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).