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LMTK3 (Lemur Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with LMTK3 include Breast Cancer. Among its related pathways are Activation of cAMP-Dependent PKA and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003674 | molecular_function | ND | -- |
GO:0004672 | protein kinase activity | IEA,IBA | 21873635 |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005575 | cellular_component | ND | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
3 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
|
5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
|
Activation of PKA through GPCR
.71
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
GO:0010923 | negative regulation of phosphatase activity | IDA | 19389623 |
GO:0016310 | phosphorylation | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LMTK3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LMTK3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LMTK3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LMTK3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lmtk3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC691056 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | LMTK3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lmtk3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LMTK3 31 |
|
OneToOne | |
Rice (Oryza sativa) |
Liliopsida | Os.46789 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716791 | Likely Benign: not provided | 48,511,511(-) | C/T | SYNONYMOUS_VARIANT | |
725219 | Likely Benign: not provided | 48,502,424(-) | C/G | INTRON_VARIANT | |
728999 | Benign: not provided | 48,502,945(-) | C/T | SYNONYMOUS_VARIANT | |
731298 | Benign: not provided | 48,491,100(-) | T/G | INTRON_VARIANT | |
738873 | Benign: not provided | 48,502,590(-) | G/C | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|