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Aliases for LMTK3 Gene

Aliases for LMTK3 Gene

  • Lemur Tyrosine Kinase 3 2 3 4 5
  • Protein Phosphatase 1, Regulatory Subunit 101 2 3
  • TYKLM3 3 4
  • Serine/Threonine-Protein Kinase LMTK3 3
  • EC 2.7.11.1 4
  • PPP1R101 3
  • KIAA1883 4
  • LMR3 3

External Ids for LMTK3 Gene

Previous GeneCards Identifiers for LMTK3 Gene

  • GC19M053680
  • GC19M048988
  • GC19M045368

Summaries for LMTK3 Gene

GeneCards Summary for LMTK3 Gene

LMTK3 (Lemur Tyrosine Kinase 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.

UniProtKB/Swiss-Prot for LMTK3 Gene

  • Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Additional gene information for LMTK3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMTK3 Gene

Genomics for LMTK3 Gene

GeneHancer (GH) Regulatory Elements for LMTK3 Gene

Promoters and enhancers for LMTK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I048514 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 +0.1 84 0.9 ARID4B SIN3A ETS1 ZNF766 GLIS2 ZNF143 KLF13 SP3 SMARCB1 MBD2 ENSG00000269814 LMTK3
GH19I048513 Promoter 1 EPDnew 550.8 +0.8 771 0.1 ZSCAN4 CHD4 PAX8 CDC5L ZNF2 ZNF664 MTA3 ARID2 ADNP ZNF114 ENSG00000269814 LMTK3 GC19P048479
GH19I047963 Enhancer 0.8 ENCODE 10.2 +550.6 550556 0.2 PKNOX1 RB1 ZNF2 RAD21 ZEB1 ARID2 SCRT2 ZNF143 MIXL1 ZNF654 PLA2G4C BSPH1 ELSPBP1 CABP5 SULT2A1 LMTK3 SYNGR4 TMEM143 SNAR-C1 GC19M047959
GH19I048462 Enhancer 0.7 ENCODE 11.6 +51.4 51406 0.2 RING1 MAX ZNF76 SIN3A DEAF1 ETS1 POLR2A EGR1 ZNF143 THAP11 SNRNP70 ENSG00000268093 SYNGR4 TMEM143 LMTK3 NTN5 ENSG00000268465 KCNJ14
GH19I048283 Enhancer 0.6 ENCODE 10.9 +229.5 229522 2 SCRT1 NFXL1 ZNF280A CBX1 CBX5 ZNF184 FOS TRIM24 KLF8 SETDB1 CCDC114 SYNGR4 TMEM143 LMTK3 IZUMO1 GRIN2D SPHK2 GC19P048288 LOC105372429 ZNF114
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LMTK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LMTK3 gene promoter:

Genomic Locations for LMTK3 Gene

Genomic Locations for LMTK3 Gene
chr19:48,485,271-48,513,905
(GRCh38/hg38)
Size:
28,635 bases
Orientation:
Minus strand
chr19:48,988,528-49,016,446
(GRCh37/hg19)

Genomic View for LMTK3 Gene

Genes around LMTK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMTK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMTK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK3 Gene

Proteins for LMTK3 Gene

  • Protein details for LMTK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q04-LMTK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK3
    Protein Accession:
    Q96Q04
    Secondary Accessions:
    • Q4G0U1

    Protein attributes for LMTK3 Gene

    Size:
    1460 amino acids
    Molecular mass:
    153661 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).
    SequenceCaution:
    • Sequence=AAH36690.1; Type=Frameshift; Positions=809; Evidence={ECO:0000305}; Sequence=BAB67776.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LMTK3 Gene

Post-translational modifications for LMTK3 Gene

  • Glycosylation at posLast=10811081 and isoforms=1405
  • Modification sites at PhosphoSitePlus

Other Protein References for LMTK3 Gene

Antibody Products

  • Abcam antibodies for LMTK3
  • Santa Cruz Biotechnology (SCBT) Antibodies for LMTK3

No data available for DME Specific Peptides for LMTK3 Gene

Domains & Families for LMTK3 Gene

Gene Families for LMTK3 Gene

Suggested Antigen Peptide Sequences for LMTK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96Q04

UniProtKB/Swiss-Prot:

LMTK3_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK3: view

Function for LMTK3 Gene

Molecular function for LMTK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Enzyme Numbers (IUBMB) for LMTK3 Gene

Gene Ontology (GO) - Molecular Function for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003674 molecular_function ND --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with LMTK3: view
genes like me logo Genes that share phenotypes with LMTK3: view

Animal Models for LMTK3 Gene

MGI Knock Outs for LMTK3:

miRNA for LMTK3 Gene

miRTarBase miRNAs that target LMTK3

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMTK3 Gene

Localization for LMTK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK3 Gene

Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMTK3 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
extracellular 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005575 cellular_component ND --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMTK3: view

Pathways & Interactions for LMTK3 Gene

genes like me logo Genes that share pathways with LMTK3: view

Interacting Proteins for LMTK3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270238%0d%0a9606.ENSP00000351697%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: Q96Q04-LMTK3_HUMAN ENSP00000270238 for LMTK3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with LMTK3: view

No data available for SIGNOR curated interactions for LMTK3 Gene

Drugs & Compounds for LMTK3 Gene

(3) Drugs for LMTK3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LMTK3: view

Transcripts for LMTK3 Gene

mRNA/cDNA for LMTK3 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LMTK3 Gene

Lemur tyrosine kinase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK3 Gene

No ASD Table

Relevant External Links for LMTK3 Gene

GeneLoc Exon Structure for
LMTK3
ECgene alternative splicing isoforms for
LMTK3

Expression for LMTK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMTK3 Gene

mRNA differential expression in normal tissues according to GTEx for LMTK3 Gene

This gene is overexpressed in Brain - Cortex (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Putamen (basal ganglia) (x4.6), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for LMTK3 Gene

This gene is overexpressed in Fetal Brain (30.3), Serum (22.6), and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMTK3 Gene



Protein tissue co-expression partners for LMTK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LMTK3 Gene:

LMTK3

SOURCE GeneReport for Unigene cluster for LMTK3 Gene:

Hs.207426

Evidence on tissue expression from TISSUES for LMTK3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with LMTK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMTK3 Gene

Orthologs for LMTK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LMTK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMTK3 33 34
  • 96.69 (n)
dog
(Canis familiaris)
Mammalia LMTK3 33 34
  • 92.07 (n)
cow
(Bos Taurus)
Mammalia LMTK3 33 34
  • 91.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LMTK3 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmtk3 33 16 34
  • 86.94 (n)
rat
(Rattus norvegicus)
Mammalia LOC691056 33
  • 86.82 (n)
lizard
(Anolis carolinensis)
Reptilia LMTK3 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmtk3 33
  • 61.47 (n)
zebrafish
(Danio rerio)
Actinopterygii LMTK3 34
  • 15 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46789 33
Species where no ortholog for LMTK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMTK3 Gene

ENSEMBL:
Gene Tree for LMTK3 (if available)
TreeFam:
Gene Tree for LMTK3 (if available)

Paralogs for LMTK3 Gene

Paralogs for LMTK3 Gene

(6) SIMAP similar genes for LMTK3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LMTK3: view

Variants for LMTK3 Gene

Sequence variations from dbSNP and Humsavar for LMTK3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000036197 -- 48,514,091(-) G/C upstream_transcript_variant
rs1000102552 -- 48,502,385(-) T/A intron_variant
rs1000107611 -- 48,515,673(-) T/C upstream_transcript_variant
rs1000257394 -- 48,496,217(-) C/T intron_variant
rs1000305799 -- 48,501,632(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LMTK3 Gene

Variant ID Type Subtype PubMed ID
nsv1057580 CNV gain 25217958
nsv518578 CNV loss 19592680
nsv817853 CNV loss 17921354
nsv828572 CNV loss 20364138
nsv9739 CNV gain+loss 18304495

Variation tolerance for LMTK3 Gene

Gene Damage Index Score: 2.92; 49.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMTK3 Gene

Human Gene Mutation Database (HGMD)
LMTK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMTK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMTK3 Gene

Disorders for LMTK3 Gene

Additional Disease Information for LMTK3

No disorders were found for LMTK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMTK3 Gene

Publications for LMTK3 Gene

  1. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. (PMID: 21602804) Giamas G … Stebbing J (Nature medicine 2011) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  4. LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer. (PMID: 28260052) Lu L … Shen B (Molecular medicine reports 2017) 3 58
  5. Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways. (PMID: 28848113) Sun P … Xu W (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58

Products for LMTK3 Gene

Sources for LMTK3 Gene

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