The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It ... See more...

Aliases for LMTK2 Gene

Aliases for LMTK2 Gene

  • Lemur Tyrosine Kinase 2 2 3 4 5
  • AATYK2 2 3 4
  • BREK 2 3 4
  • KPI2 2 3 4
  • LMR2 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 100 2 3
  • Apoptosis-Associated Tyrosine Kinase 2 3 4
  • Serine/Threonine-Protein Kinase LMTK2 3 4
  • Serine/Threonine-Protein Kinase KPI-2 3 4
  • Kinase/Phosphatase/Inhibitor 2 3 4
  • CDK5/P35-Regulated Kinase 3 4
  • Brain-Enriched Kinase 3 4
  • EC 2.7.11.1 4 50
  • PPP1R100 2 3
  • KIAA1079 2 4
  • KPI-2 2 3
  • HBREK 3 4
  • Cprk 2 3
  • Cyclin-Dependent Kinase 5/P35-Regulated Kinase 3
  • EC 2.7.11 50
  • LMTK2 5
  • CPRK 4

External Ids for LMTK2 Gene

Previous GeneCards Identifiers for LMTK2 Gene

  • GC07P097347
  • GC07P097380
  • GC07P097574
  • GC07P097736
  • GC07P092337

Summaries for LMTK2 Gene

Entrez Gene Summary for LMTK2 Gene

  • The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

GeneCards Summary for LMTK2 Gene

LMTK2 (Lemur Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with LMTK2 include Spinal Cord Astrocytoma. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TYRO3.

UniProtKB/Swiss-Prot Summary for LMTK2 Gene

Gene Wiki entry for LMTK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LMTK2 Gene

Genomics for LMTK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LMTK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LMTK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LMTK2

Top Transcription factor binding sites by QIAGEN in the LMTK2 gene promoter:
  • Bach1
  • CUTL1
  • E47
  • Hlf
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for LMTK2 Gene

Latest Assembly
chr7:98,106,862-98,209,638
(GRCh38/hg38)
Size:
102,777 bases
Orientation:
Plus strand

Previous Assembly
chr7:97,736,174-97,838,950
(GRCh37/hg19 by Entrez Gene)
Size:
102,777 bases
Orientation:
Plus strand

chr7:97,736,197-97,838,945
(GRCh37/hg19 by Ensembl)
Size:
102,749 bases
Orientation:
Plus strand

Genomic View for LMTK2 Gene

Genes around LMTK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMTK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMTK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK2 Gene

Proteins for LMTK2 Gene

  • Protein details for LMTK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU2-LMTK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK2
    Protein Accession:
    Q8IWU2
    Secondary Accessions:
    • A4D272
    • Q75MG7
    • Q9UPS3

    Protein attributes for LMTK2 Gene

    Size:
    1503 amino acids
    Molecular mass:
    164900 Da
    Quaternary structure:
    • Interacts with PPP1C and inhibitor-2.
    SequenceCaution:
    • Sequence=BAA83031.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LMTK2 Gene

Selected DME Specific Peptides for LMTK2 Gene

Q8IWU2:
  • LVFEFCD
  • HSDLALRNC

Post-translational modifications for LMTK2 Gene

Other Protein References for LMTK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LMTK2 Gene

Gene Families for LMTK2 Gene

Protein Domains for LMTK2 Gene

Suggested Antigen Peptide Sequences for LMTK2 Gene

GenScript: Design optimal peptide antigens:
  • LMTK2 protein (A2VDI9_HUMAN)
  • Serine/threonine-protein kinase KPI-2 (LMTK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IWU2

UniProtKB/Swiss-Prot:

LMTK2_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK2: view

Function for LMTK2 Gene

Molecular function for LMTK2 Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for LMTK2 Gene

Phenotypes From GWAS Catalog for LMTK2 Gene

Gene Ontology (GO) - Molecular Function for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 12393858
GO:0004714 NOT transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0004864 protein phosphatase inhibitor activity IDA 12393858
genes like me logo Genes that share ontologies with LMTK2: view
genes like me logo Genes that share phenotypes with LMTK2: view

Animal Models for LMTK2 Gene

MGI Knock Outs for LMTK2:

Animal Models for research

  • Taconic Biosciences Mouse Models for LMTK2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMTK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMTK2 Gene

Localization for LMTK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMTK2 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 4
cytoskeleton 3
nucleus 3
cytosol 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 18029400
GO:0005794 Golgi apparatus IDA 12832520
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LMTK2: view

Pathways & Interactions for LMTK2 Gene

PathCards logo

SuperPathways for LMTK2 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
4 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
5 Activation of cAMP-Dependent PKA
.77
.71
genes like me logo Genes that share pathways with LMTK2: view

Pathways by source for LMTK2 Gene

28 Qiagen pathways for LMTK2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

SIGNOR curated interactions for LMTK2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IMP 18029400
GO:0006468 protein phosphorylation IDA 12393858
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0007275 multicellular organism development IBA 21873635
GO:0007409 axonogenesis IBA 21873635
genes like me logo Genes that share ontologies with LMTK2: view

Drugs & Compounds for LMTK2 Gene

(1) Drugs for LMTK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra 0

(1) Additional Compounds for LMTK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with LMTK2: view

Transcripts for LMTK2 Gene

mRNA/cDNA for LMTK2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMTK2

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK2 Gene

No ASD Table

Relevant External Links for LMTK2 Gene

GeneLoc Exon Structure for
LMTK2

Expression for LMTK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMTK2 Gene

Protein differential expression in normal tissues from HIPED for LMTK2 Gene

This gene is overexpressed in Adrenal (42.7) and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LMTK2 Gene



Protein tissue co-expression partners for LMTK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LMTK2

SOURCE GeneReport for Unigene cluster for LMTK2 Gene:

Hs.444179

mRNA Expression by UniProt/SwissProt for LMTK2 Gene:

Q8IWU2-LMTK2_HUMAN
Tissue specificity: Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

Evidence on tissue expression from TISSUES for LMTK2 Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with LMTK2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMTK2 Gene

Orthologs for LMTK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMTK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LMTK2 29 30
  • 99.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LMTK2 29 30
  • 83.79 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 83 (a)
OneToMany
-- 30
  • 62 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LMTK2 29 30
  • 79.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lmtk2 29 16 30
  • 78.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lmtk2 29
  • 77.7 (n)
Oppossum
(Monodelphis domestica)
Mammalia LMTK2 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LMTK2 29 30
  • 63.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LMTK2 30
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lmtk2 29
  • 61.15 (n)
Zebrafish
(Danio rerio)
Actinopterygii lmtk2 30
  • 42 (a)
OneToOne
Species where no ortholog for LMTK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LMTK2 Gene

ENSEMBL:
Gene Tree for LMTK2 (if available)
TreeFam:
Gene Tree for LMTK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LMTK2: view image
Alliance of Genome Resources:
Additional Orthologs for LMTK2

Paralogs for LMTK2 Gene

(3) SIMAP similar genes for LMTK2 Gene using alignment to 3 proteins:

  • LMTK2_HUMAN
  • A2VDI9_HUMAN
  • L8E8L1_HUMAN
genes like me logo Genes that share paralogs with LMTK2: view

Variants for LMTK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LMTK2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs116216163 Benign: not provided 98,203,615(+) G/C
NM_014916.4(LMTK2):c.4149G>C (p.Ala1383=)
SYNONYMOUS
rs116651302 Benign: not provided 98,193,194(+) G/T
NM_014916.4(LMTK2):c.2729G>T (p.Ser910Ile)
MISSENSE
rs143954866 Benign: not provided 98,193,777(+) G/A
NM_014916.4(LMTK2):c.3312G>A (p.Ala1104=)
SYNONYMOUS
rs146056893 Benign: not provided 98,193,489(+) G/A
NM_014916.4(LMTK2):c.3024G>A (p.Ala1008=)
SYNONYMOUS
rs147940573 A lung large cell carcinoma sample p.Asp484His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LMTK2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LMTK2 Gene

Variant ID Type Subtype PubMed ID
esv1940302 CNV deletion 18987734
esv2734865 CNV deletion 23290073
esv2734866 CNV deletion 23290073
esv275549 OTHER complex 21479260
esv3614247 CNV loss 21293372
esv3614248 CNV loss 21293372
esv3614249 CNV loss 21293372
esv3614250 CNV gain 21293372
nsv5859 CNV insertion 18451855
nsv831066 CNV loss 17160897

Variation tolerance for LMTK2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.01; 92.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMTK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMTK2
Leiden Open Variation Database (LOVD)
LMTK2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMTK2 Gene

Disorders for LMTK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LMTK2 Gene - From: COP

Disorder Aliases PubMed IDs
spinal cord astrocytoma
  • astrocytoma of spinal cord
- elite association - COSMIC cancer census association via MalaCards
Search LMTK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LMTK2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LMTK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMTK2 Gene

Publications for LMTK2 Gene

  1. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. (PMID: 15005709) Kawa S … Yamamoto T (Genes to cells : devoted to molecular & cellular mechanisms 2004) 2 3 4
  2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PMID: 12393858) Wang H … Brautigan DL (The Journal of biological chemistry 2002) 3 4 22
  3. Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection. (PMID: 23114966) Nixon A … Bradbury NA (American journal of physiology. Cell physiology 2013) 3 4
  4. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PMID: 20878950) Sun J … Xu J (The Prostate 2011) 3 40
  5. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PMID: 20564319) Kim ST … Sun J (The Prostate 2010) 3 40

Products for LMTK2 Gene

  • Boster Bio Antibodies for LMTK2
  • Boster Bio ELISA Kits for LMTK2

Sources for LMTK2 Gene