Aliases for LMTK2 Gene
External Ids for LMTK2 Gene
Previous GeneCards Identifiers for LMTK2 Gene
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
GeneCards Summary for LMTK2 Gene
LMTK2 (Lemur Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with LMTK2 include Deafness, Autosomal Recessive 37 and Deafness, Autosomal Dominant 22. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.
UniProtKB/Swiss-Prot for LMTK2 Gene
Phosphorylates PPP1C, phosphorylase b and CFTR.