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Aliases for LMTK2 Gene

Aliases for LMTK2 Gene

  • Lemur Tyrosine Kinase 2 2 3 4 5
  • Protein Phosphatase 1, Regulatory Subunit 100 2 3
  • Apoptosis-Associated Tyrosine Kinase 2 3 4
  • Serine/Threonine-Protein Kinase KPI-2 3 4
  • Kinase/Phosphatase/Inhibitor 2 3 4
  • CDK5/P35-Regulated Kinase 3 4
  • Brain-Enriched Kinase 3 4
  • AATYK2 3 4
  • HBREK 3 4
  • BREK 3 4
  • KPI2 3 4
  • LMR2 3 4
  • Cyclin-Dependent Kinase 5/P35-Regulated Kinase 3
  • Serine/Threonine-Protein Kinase LMTK2 3
  • EC 2.7.11.1 4
  • PPP1R100 3
  • KIAA1079 4
  • KPI-2 3
  • Cprk 3
  • CPRK 4

External Ids for LMTK2 Gene

Previous GeneCards Identifiers for LMTK2 Gene

  • GC07P097347
  • GC07P097380
  • GC07P097574
  • GC07P097736
  • GC07P092337

Summaries for LMTK2 Gene

Entrez Gene Summary for LMTK2 Gene

  • The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

GeneCards Summary for LMTK2 Gene

LMTK2 (Lemur Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with LMTK2 include Deafness, Autosomal Recessive 37 and Deafness, Autosomal Dominant 22. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.

UniProtKB/Swiss-Prot for LMTK2 Gene

  • Phosphorylates PPP1C, phosphorylase b and CFTR.

Gene Wiki entry for LMTK2 Gene

Additional gene information for LMTK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMTK2 Gene

Genomics for LMTK2 Gene

GeneHancer (GH) Regulatory Elements for LMTK2 Gene

Promoters and enhancers for LMTK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J098105 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658.3 +0.4 410 2.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 LMTK2 TRRAP LOC100419643 RPS3AP26 GC07M098123
GH07J098130 Enhancer 1.5 FANTOM5 Ensembl ENCODE 25.2 +26.1 26062 5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 E2F8 FOS LMTK2 ENSG00000272950 BRI3 GC07P098137 GC07M098123
GH07J098163 Enhancer 1 Ensembl ENCODE 17.9 +57.4 57383 2.3 PKNOX1 INSM2 MZF1 FEZF1 RAD21 ZNF366 ZSCAN5C SCRT2 ZFP91 RCOR1 LMTK2 TECPR1 GC07M098146 PIR34704
GH07J098202 Enhancer 1 Ensembl ENCODE 16.5 +96.1 96063 1.5 STAT5A BMI1 BATF KLF5 IRF4 SCRT2 ZNF207 ZNF143 ATF7 ETV6 LMTK2 BRI3 TECPR1 BHLHA15 PIR34704
GH07J098200 Enhancer 0.8 Ensembl ENCODE 16.2 +93.7 93655 0.4 CBFB NR2F1 PAX8 EBF1 BATF ATF2 ZNF217 EED IKZF1 NFATC1 LMTK2 PIR34704 BHLHA15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LMTK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LMTK2 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Bach1
  • Nkx2-5
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • CUTL1
  • Hlf
  • E47

Genomic Locations for LMTK2 Gene

Genomic Locations for LMTK2 Gene
chr7:98,106,875-98,209,636
(GRCh38/hg38)
Size:
102,762 bases
Orientation:
Plus strand
chr7:97,736,197-97,838,945
(GRCh37/hg19)
Size:
102,749 bases
Orientation:
Plus strand

Genomic View for LMTK2 Gene

Genes around LMTK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMTK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMTK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK2 Gene

Proteins for LMTK2 Gene

  • Protein details for LMTK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU2-LMTK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK2
    Protein Accession:
    Q8IWU2
    Secondary Accessions:
    • A4D272
    • Q75MG7
    • Q9UPS3

    Protein attributes for LMTK2 Gene

    Size:
    1503 amino acids
    Molecular mass:
    164900 Da
    Quaternary structure:
    • Interacts with PPP1C and inhibitor-2.
    SequenceCaution:
    • Sequence=BAA83031.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LMTK2 Gene

Post-translational modifications for LMTK2 Gene

Other Protein References for LMTK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LMTK2 Gene

Domains & Families for LMTK2 Gene

Suggested Antigen Peptide Sequences for LMTK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWU2

UniProtKB/Swiss-Prot:

LMTK2_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK2: view

Function for LMTK2 Gene

Molecular function for LMTK2 Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for LMTK2 Gene

Phenotypes From GWAS Catalog for LMTK2 Gene

Gene Ontology (GO) - Molecular Function for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 12393858
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IBA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA --
genes like me logo Genes that share ontologies with LMTK2: view
genes like me logo Genes that share phenotypes with LMTK2: view

Animal Models for LMTK2 Gene

MGI Knock Outs for LMTK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LMTK2

Clone Products

  • Addgene plasmids for LMTK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMTK2 Gene

Localization for LMTK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMTK2 gene
Compartment Confidence
golgi apparatus 5
endosome 5
plasma membrane 3
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubule organizing center (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005769 early endosome IDA 18029400
GO:0005794 Golgi apparatus IDA 12832520
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with LMTK2: view

Pathways & Interactions for LMTK2 Gene

genes like me logo Genes that share pathways with LMTK2: view

SIGNOR curated interactions for LMTK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IMP 18029400
GO:0006468 protein phosphorylation IDA 12393858
GO:0007275 multicellular organism development IBA --
GO:0009968 negative regulation of signal transduction IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with LMTK2: view

Drugs & Compounds for LMTK2 Gene

(1) Drugs for LMTK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for LMTK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with LMTK2: view

Transcripts for LMTK2 Gene

mRNA/cDNA for LMTK2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(143) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LMTK2 Gene

Lemur tyrosine kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for LMTK2

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK2 Gene

No ASD Table

Relevant External Links for LMTK2 Gene

GeneLoc Exon Structure for
LMTK2
ECgene alternative splicing isoforms for
LMTK2

Expression for LMTK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMTK2 Gene

Protein differential expression in normal tissues from HIPED for LMTK2 Gene

This gene is overexpressed in Adrenal (42.7) and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LMTK2 Gene



Protein tissue co-expression partners for LMTK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LMTK2 Gene:

LMTK2

SOURCE GeneReport for Unigene cluster for LMTK2 Gene:

Hs.444179

mRNA Expression by UniProt/SwissProt for LMTK2 Gene:

Q8IWU2-LMTK2_HUMAN
Tissue specificity: Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

Evidence on tissue expression from TISSUES for LMTK2 Gene

  • Nervous system(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with LMTK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMTK2 Gene

Orthologs for LMTK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMTK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMTK2 34 33
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LMTK2 34 33
  • 83.79 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LMTK2 34 33
  • 79.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lmtk2 16 34 33
  • 78.99 (n)
rat
(Rattus norvegicus)
Mammalia Lmtk2 33
  • 77.7 (n)
oppossum
(Monodelphis domestica)
Mammalia LMTK2 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMTK2 34 33
  • 63.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMTK2 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmtk2 33
  • 61.15 (n)
zebrafish
(Danio rerio)
Actinopterygii lmtk2 34
  • 42 (a)
OneToOne
Species where no ortholog for LMTK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMTK2 Gene

ENSEMBL:
Gene Tree for LMTK2 (if available)
TreeFam:
Gene Tree for LMTK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LMTK2: view image

Paralogs for LMTK2 Gene

Paralogs for LMTK2 Gene

(3) SIMAP similar genes for LMTK2 Gene using alignment to 3 proteins:

  • LMTK2_HUMAN
  • A2VDI9_HUMAN
  • L8E8L1_HUMAN
genes like me logo Genes that share paralogs with LMTK2: view

Variants for LMTK2 Gene

Sequence variations from dbSNP and Humsavar for LMTK2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs147940573 A lung large cell carcinoma sample 98,191,915(+) G/A/C coding_sequence_variant, missense_variant
rs864622025 uncertain-significance, Malignant tumor of prostate 98,159,417(+) TGTG/TG coding_sequence_variant, inframe_indel, stop_gained
rs1000019411 -- 98,200,840(+) A/G intron_variant
rs1000020941 -- 98,132,352(+) G/A intron_variant
rs1000021967 -- 98,165,072(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LMTK2 Gene

Variant ID Type Subtype PubMed ID
esv1940302 CNV deletion 18987734
esv2734865 CNV deletion 23290073
esv2734866 CNV deletion 23290073
esv275549 OTHER complex 21479260
esv3614247 CNV loss 21293372
esv3614248 CNV loss 21293372
esv3614249 CNV loss 21293372
esv3614250 CNV gain 21293372
nsv5859 CNV insertion 18451855
nsv831066 CNV loss 17160897

Variation tolerance for LMTK2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.01; 92.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMTK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMTK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMTK2 Gene

Disorders for LMTK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LMTK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 37
  • dfnb37
deafness, autosomal dominant 22
  • dfna22
- elite association - COSMIC cancer census association via MalaCards
Search LMTK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LMTK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LMTK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMTK2 Gene

Publications for LMTK2 Gene

  1. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. (PMID: 15005709) Kawa S … Yamamoto T (Genes to cells : devoted to molecular & cellular mechanisms 2004) 2 3 4 58
  2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PMID: 12393858) Wang H … Brautigan DL (The Journal of biological chemistry 2002) 3 4 22 58
  3. Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection. (PMID: 23114966) Nixon A … Bradbury NA (American journal of physiology. Cell physiology 2013) 3 4 58
  4. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PMID: 20878950) Sun J … Xu J (The Prostate 2011) 3 44 58
  5. Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men. (PMID: 19866473) Zheng SL … Xu J (The Prostate 2010) 3 44 58

Products for LMTK2 Gene

Sources for LMTK2 Gene

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