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This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
LMO4 (LIM Domain Only 4) is a Protein Coding gene. Diseases associated with LMO4 include Immunodeficiency 29 and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Neuroscience and IL6-mediated signaling events. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enhancer sequence-specific DNA binding. An important paralog of this gene is LMO1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15231748 |
GO:0008134 | transcription factor binding | ISS | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005667 | transcription factor complex | ISS | -- |
GO:0031252 | cell leading edge | ISS | -- |
GO:0090575 | RNA polymerase II transcription factor complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neuroscience | ||
2 | Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
3 | IL6-mediated signaling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001843 | neural tube closure | ISS | -- |
GO:0003281 | ventricular septum development | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0021514 | ventral spinal cord interneuron differentiation | IEA | -- |
GO:0021522 | spinal cord motor neuron differentiation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LMO4 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LMO4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LMO4 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LMO4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LMO4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lmo4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lmo4 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LMO4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LMO4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lmo4.1 30 |
|
||
Str.145 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24588 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lmo4b 30 31 |
|
OneToOne | |
Dr.19236 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5708 30 31 32 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24748 | CNV | gain | 19812545 |
nsv1077471 | CNV | deletion | 25765185 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 29 |
|
|
attention deficit-hyperactivity disorder |
|
|