Aliases for LMO2 Gene
External Ids for LMO2 Gene
Previous HGNC Symbols for LMO2 Gene
Previous GeneCards Identifiers for LMO2 Gene
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
GeneCards Summary for LMO2 Gene
LMO2 (LIM Domain Only 2) is a Protein Coding gene. Diseases associated with LMO2 include Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is LMO1.
UniProtKB/Swiss-Prot for LMO2 Gene
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.