Aliases for LMO2 Gene
Aliases for LMO2 Gene
External Ids for LMO2 Gene
- HGNC: 6642
- Entrez Gene: 4005
- Ensembl: ENSG00000135363
- OMIM: 180385
- UniProtKB: P25791
Previous HGNC Symbols for LMO2 Gene
- RBTNL1
Previous GeneCards Identifiers for LMO2 Gene
- GC11M035411
- GC11M034557
- GC11M033919
- GC11M033844
- GC11M033836
- GC11M033576
Summaries for LMO2 Gene
-
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
GeneCards Summary for LMO2 Gene
LMO2 (LIM Domain Only 2) is a Protein Coding gene. Diseases associated with LMO2 include Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Hematopoietic Stem Cell Differentiation and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is LMO1.
UniProtKB/Swiss-Prot for LMO2 Gene
-
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Additional gene information for LMO2 Gene
- Monarch Initiative
- Search for LMO2 at DataMed
- Search for LMO2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO2 Gene
Genomics for LMO2 Gene
GeneHancer (GH) Regulatory Elements for LMO2 Gene
Promoters and enhancers for LMO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LMO2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LMO2 gene promoter:
Regulatory Element Products
Genomic Locations for LMO2 Gene
Genomic Locations for LMO2 Gene
- chr11:33,858,576-33,892,289
- (GRCh38/hg38)
- Size:
- 33,714 bases
- Orientation:
- Minus strand
- chr11:33,880,122-33,913,836
- (GRCh37/hg19)
Genomic View for LMO2 Gene
Genes around LMO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p13 by Ensembl
- 11p13 by Entrez Gene
- 11p13 by HGNC
LMO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LMO2 Gene
Proteins for LMO2 Gene
-
Protein details for LMO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25791-RBTN2_HUMAN
- Recommended name:
- Rhombotin-2
- Protein Accession:
- P25791
- Q9HD58
Protein attributes for LMO2 Gene
- Size:
- 158 amino acids
- Molecular mass:
- 18358 Da
- Quaternary structure:
-
- Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.
- SequenceCaution:
-
- Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH73973.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAA43430.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for LMO2 Gene
Protein Expression for LMO2 Gene
Post-translational modifications for LMO2 Gene
Other Protein References for LMO2 Gene
Antibody Products
- R&D Systems Antibodies for LMO2 (LMO2)
- Novus Biologicals Antibodies for LMO2
-
Abcam antibodies for LMO2
- Invitrogen Antibodies for LMO2
- GeneTex LMO2 antibody for LMO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for LMO2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for LMO2
- Origene Custom Protein Services for LMO2
- GeneTex Proteins for LMO2
-
Abcam proteins for LMO2
Assay Products
No data available for DME Specific Peptides for LMO2 Gene
Domains & Families for LMO2 Gene
Gene Families for LMO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for LMO2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LMO2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25791- Domain:
-
- The second LIM zinc-binding domain interacts with KDM5A.
Function for LMO2 Gene
Molecular function for LMO2 Gene
- GENATLAS Biochemistry:
- LIM domain only 2,rhombotin 2,involved in association with LMO1 (and others),in the formation of multimeric DNA-binding complex for the generation of hematopoietic lineages and angiogenesis (in mice)
- UniProtKB/Swiss-Prot Function:
- Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Phenotypes From GWAS Catalog for LMO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 16314316 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IDA | 16314316 |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 16314316 |
| GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding | IDA | 16314316 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 16314316 |
Phenotypes for LMO2 Gene
- MGI mutant phenotypes for LMO2:
-
inferred from 4 alleles
- nervous system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for LMO2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LMO2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LMO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LMO2 gene
- Search ViGene Biosciences for LMO2
CRISPR Products
-
OriGene CRISPR knockouts for LMO2
- genomics-online: gRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for LMO2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
- GenScript: Design CRISPR guide RNA sequences for LMO2
miRNA for LMO2 Gene
- miRTarBase miRNAs that target LMO2
Transcription Factor Targets for LMO2 Gene
miRNA Products
- Search ViGene Biosciences for LMO2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- genomics-online: shRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for LMO2 gene
Clone Products
- Sino Biological Human cDNA Clone for LMO2
- VectorBuilder custom plasmid, inducible vectors for LMO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LMO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LMO2
- genomics-online: cdna clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- orf clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials Clones for LMO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LMO2
-
ViGene Biosciences adenoviral particle packaged cDNA for LMO2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LMO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LMO2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for LMO2 Gene
Localization for LMO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LMO2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IDA | 16314316 |
Pathways & Interactions for LMO2 Gene
Pathways by source for LMO2 Gene
1 BioSystems pathway for LMO2 Gene
1 KEGG pathway for LMO2 Gene
1 R&D Systems pathway for LMO2 Gene
Interacting Proteins for LMO2 Gene
Selected Interacting proteins:
ENSP00000257818
P25791-RBTN2_HUMAN
for LMO2 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | TAS | 1923511 |
| GO:0042789 | mRNA transcription by RNA polymerase II | IDA | 16314316 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 16314316 |
| GO:0097067 | cellular response to thyroid hormone stimulus | IDA | 19375645 |
| GO:1902036 | regulation of hematopoietic stem cell differentiation | TAS | -- |
Transcripts for LMO2 Gene
mRNA/cDNA for LMO2 Gene
- (11) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (151) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LMO2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for LMO2
- genomics-online: gRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for LMO2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
- GenScript: Design CRISPR guide RNA sequences for LMO2
miRNA Products
- Search ViGene Biosciences for LMO2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- genomics-online: shRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for LMO2 gene
Clone Products
- Sino Biological Human cDNA Clone for LMO2
- VectorBuilder custom plasmid, inducible vectors for LMO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LMO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LMO2
- genomics-online: cdna clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- orf clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials Clones for LMO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: |
Expression for LMO2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Hemangioblasts Posterior Primitive Streak
- Primitive Erythrocytes Extraembryonic Blood Islands
- Hematopoietic Stem Cells Liver Bud
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Limb Bud Mesenchyme Cells Limb Bud
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Primitive Erythrocytes Extraembryonic Blood Islands
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Primitive Streak (Early Embryonic Tissues)
- Hemangioblasts Posterior Primitive Streak
-
Endothelium (Cardiovascular System)
- Hemangioblasts Posterior Primitive Streak
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Yolk Sac (Extraembryonic Tissues)
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Umbilical Cord (Extraembryonic Tissues)
- Lung (Respiratory System)
- NULL (Uncategorized)
- Cartilage (Muscoskeletal System)
This gene is overexpressed in Fetal Liver (48.0) and Placenta (21.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LMO2 Gene
NURSA nuclear receptor signaling pathways regulating expression of LMO2 Gene:
LMO2SOURCE GeneReport for Unigene cluster for LMO2 Gene:
Hs.34560Evidence on tissue expression from TISSUES for LMO2 Gene
- Nervous system(4.4)
- Kidney(4.3)
- Intestine(4.2)
- Blood(3)
- Bone marrow(2.5)
- Lymph node(2.4)
Primer Products
-
OriGene qPCR primer pairs for LMO2
-
OriGene qPCR primer pairs and template standards for LMO2
- genomics-online: primer clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMO2 Gene
Orthologs for LMO2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LMO2 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | LMO2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LMO2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Lmo2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Lmo2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC609006 33 |
|
||
| LMO2 34 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LMO2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LMO2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | LMO2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lmo2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | lmo2-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lmo2 33 34 |
|
- Species where no ortholog for LMO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for LMO2 Gene
Paralogs for LMO2 Gene
(16) SIMAP similar genes for LMO2 Gene using alignment to 1 proteins:
Variants for LMO2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025412 | -- | 33,864,043(-) | C/G | intron_variant | |
| rs1000109210 | -- | 33,892,009(-) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000306348 | -- | 33,877,621(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000385660 | -- | 33,864,410(-) | G/C | intron_variant | |
| rs1000419347 | -- | 33,882,095(-) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1115754 | CNV | insertion | 17803354 |
| nsv1069574 | CNV | deletion | 25765185 |
| nsv1118207 | CNV | deletion | 24896259 |
| nsv1147622 | CNV | insertion | 26484159 |
| nsv509398 | CNV | insertion | 20534489 |
| nsv519717 | CNV | loss | 19592680 |
| nsv526555 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LMO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LMO2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO2 Gene
Disorders for LMO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoblastic leukemia |
|
|
| t-cell leukemia |
|
|
| acute t cell leukemia |
|
|
| diffuse large b-cell lymphoma |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
Search LMO2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RBTN2_HUMAN- Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
Genatlas disease for LMO2 Gene
acute lymphoblastic leukemia (T-ALL),with translocations t(11;14)(p13;q11),t(7;11)(p35;p13)
Additional Disease Information for LMO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for LMO2 Gene
- Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PMID: 16314316) Han C … Peng X (Nucleic acids research 2005) 3 4 22 58
- T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PMID: 9129143) Mao S … Goorha RM (Oncogene 1997) 3 4 22 58
- The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PMID: 2034676) Boehm T … Rabbitts TH (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 22 58
- TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). (PMID: 1923511) Royer-Pokora B … Ludwig WD (Oncogene 1991) 3 4 22 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
Products for LMO2 Gene
- R&D Systems Antibodies for LMO2 (LMO2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for LMO2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for LMO2
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- OriGene qPCR primer pairs and template standards for LMO2
- OriGene qPCR primer pairs for LMO2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for LMO2
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for LMO2
- VectorBuilder custom plasmid, inducible vectors for LMO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LMO2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LMO2
- antibodies-online: Search results for 148 available LMO2 Antibodies ranked by validation data
- Compare Top LMO2 Antibodies
- antibodies-online: Search results for 3 available LMO2 Elisa Kits ranked by validation data
- Compare Top LMO2 Elisa Kits
- antibodies-online: Search results for 11 available LMO2 Proteins ranked by validation data
- Compare Top LMO2 Proteins
- GeneTex LMO2 antibody for LMO2
- GeneTex Proteins for LMO2
- ViGene Biosciences adenoviral particle packaged cDNA for LMO2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for LMO2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for LMO2 gene
- Search ViGene Biosciences for LMO2
- Santa Cruz Biotechnology (SCBT) Antibodies for LMO2
- Search Santa Cruz Biotechnology (SCBT) for LMO2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
- Horizon Cell Lines for LMO2
- genomics-online: cdna clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- orf clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- genomics-online: primer clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
Sources for LMO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems