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LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leuk... See more...
Aliases for LMO2 Gene
Aliases for LMO2 Gene
External Ids for LMO2 Gene
- HGNC: 6642
- Entrez Gene: 4005
- Ensembl: ENSG00000135363
- OMIM: 180385
- UniProtKB: P25791
Previous HGNC Symbols for LMO2 Gene
- RBTNL1
Previous GeneCards Identifiers for LMO2 Gene
- GC11M035411
- GC11M034557
- GC11M033919
- GC11M033844
- GC11M033836
- GC11M033576
- GC11M033880
Summaries for LMO2 Gene
-
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
GeneCards Summary for LMO2 Gene
LMO2 (LIM Domain Only 2) is a Protein Coding gene. Diseases associated with LMO2 include T-Cell Acute Lymphoblastic Leukemia and Severe Combined Immunodeficiency, X-Linked. Among its related pathways are Transcriptional misregulation in cancer and Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is LMO1.
UniProtKB/Swiss-Prot Summary for LMO2 Gene
-
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Additional gene information for LMO2 Gene
- HGNC(6642)
- Entrez Gene(4005)
- Ensembl(ENSG00000135363)
- OMIM(180385)
- UniProtKB(P25791)
- Open Targets Platform(ENSG00000135363)
- Monarch Initiative
- Search for LMO2 at DataMed
- Search for LMO2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LMO2 Gene
Genomics for LMO2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LMO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LMO2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LMO2
- Top Transcription factor binding sites by QIAGEN in the LMO2 gene promoter:
-
- AML1a
Genomic Locations for LMO2 Gene
Genomic Locations for LMO2 Gene
- chr11:33,858,576-33,892,076
- (GRCh38/hg38)
- Size:
- 33,501 bases
- Orientation:
- Minus strand
- chr11:33,880,122-33,913,836
- (GRCh37/hg19)
- Size:
- 33,715 bases
- Orientation:
- Minus strand
Genomic View for LMO2 Gene
Genes around LMO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p13 by HGNC
- 11p13 by Entrez Gene
- 11p13 by Ensembl
LMO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LMO2 Gene
Proteins for LMO2 Gene
-
Protein details for LMO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25791-RBTN2_HUMAN
- Recommended name:
- Rhombotin-2
- Protein Accession:
- P25791
- Q9HD58
Protein attributes for LMO2 Gene
- Size:
- 158 amino acids
- Molecular mass:
- 18358 Da
- Quaternary structure:
-
- Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.
- SequenceCaution:
-
- Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH73973.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAA43430.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Three dimensional structures from OCA and Proteopedia for LMO2 Gene
Protein Expression for LMO2 Gene
Post-translational modifications for LMO2 Gene
Other Protein References for LMO2 Gene
Antibody Products
- NSJ Bioreagents LMO2 Antibody
- Novus Biologicals Antibodies for LMO2
-
Abcam antibodies for LMO2
- Invitrogen Antibodies for LMO2 (AFLGC-Lmo2)
-
Biorbyt antibodies for LMO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for LMO2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for LMO2
- Origene Custom Protein Services for LMO2
-
Abcam proteins for LMO2
Assay Products
- antibodies-online: Show 5 available LMO2 Elisa Kits ranked by validation data
- Compare Top LMO2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for LMO2 Gene
Domains & Families for LMO2 Gene
Gene Families for LMO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for LMO2 Gene
- GenScript: Design optimal peptide antigens:
-
- T-cell translocation protein 2 (RBTN2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P25791- Domain:
-
- The second LIM zinc-binding domain interacts with KDM5A.
Function for LMO2 Gene
Molecular function for LMO2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
- GENATLAS Biochemistry:
- LIM domain only 2,rhombotin 2,involved in association with LMO1 (and others),in the formation of multimeric DNA-binding complex for the generation of hematopoietic lineages and angiogenesis (in mice)
Phenotypes From GWAS Catalog for LMO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 16314316 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA | 16314316 |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 16314316 |
| GO:0001221 | transcription cofactor binding | IPI | 16314316 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 16314316 |
Phenotypes for LMO2 Gene
- MGI mutant phenotypes for LMO2:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for LMO2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Increased epidermal growth factor (EGF) endocytosis
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Proliferating cells
- Decreased HPV16-GFP infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LMO2 - Select products 50% OFF >
- * LMO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LMO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LMO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
miRNA for LMO2 Gene
- miRTarBase miRNAs that target LMO2
Transcription Factor Targets for LMO2 Gene
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMO2
Clone Products
- Applied Biological Materials (abm): Clones for LMO2 - Select products 50% OFF >
- * LMO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223465
- MG223467
- MG224680
- MG225099
- MR223465
- MR223465L3
- MR223465L4
- MR223467
- MR223467L3
- MR223467L4
- MR224680
- MR224680L3
- MR224680L4
- MR225099
- MR225099L3
- MR225099L4
- RC205376
- RC205376L1
- RC205376L2
- RC205376L3
- RC205376L4
- RC226762
- RC226762L3
- RC226762L4
- RC226864
- RC226864L3
- RC226864L4
- RC229124
- RC229124L1
- RC229124L3
- RG205376
- RG226762
- RG226864
- RG229124
- RR209476
- RR209476L3
- RR209476L4
- RR215927
- RR215928
- RR215929
- MR223465L3V
- MR223465L4V
- MR223467L3V
- MR223467L4V
- MR224680L3V
- MR224680L4V
- MR225099L3V
- MR225099L4V
- RC205376L1V
- RC205376L2V
- RC205376L3V
- RC205376L4V
- RC226762L3V
- RC226762L4V
- RC226864L3V
- RC226864L4V
- RC229124L1V
- RC229124L3V
- RR209476L3V
- RR209476L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LMO2
- Addgene plasmids for LMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LMO2
Cell Line Products
-
Horizon Cell Lines for LMO2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for LMO2 Gene
Localization for LMO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LMO2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IDA | 16314316 |
Pathways & Interactions for LMO2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcriptional misregulation in cancer | ||
| 2 | Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers | ||
| 3 | Hematopoietic Stem Cell Differentiation | ||
Pathways by source for LMO2 Gene
1 BioSystems pathway for LMO2 Gene
1 KEGG pathway for LMO2 Gene
1 R&D Systems pathway for LMO2 Gene
Interacting Proteins for LMO2 Gene
Selected Interacting proteins:
P25791-RBTN2_HUMAN
ENSP00000257818
for LMO2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LMO2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | TAS | 1923511 |
| GO:0042789 | mRNA transcription by RNA polymerase II | IDA | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 16314316 |
| GO:0097067 | cellular response to thyroid hormone stimulus | IDA | 19375645 |
| GO:1902036 | regulation of hematopoietic stem cell differentiation | TAS | -- |
Transcripts for LMO2 Gene
mRNA/cDNA for LMO2 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000257818 2081 nts (view in UCSC)
- ENST00000395833 1687 nts (view in UCSC)
- ENST00000411482 1519 nts (view in UCSC)
- ENST00000464025 1550 nts (view in UCSC)
- ENST00000465614 869 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LMO2 - Select products 50% OFF >
- * LMO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LMO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LMO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMO2
Clone Products
- Applied Biological Materials (abm): Clones for LMO2 - Select products 50% OFF >
- * LMO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223465
- MG223467
- MG224680
- MG225099
- MR223465
- MR223465L3
- MR223465L4
- MR223467
- MR223467L3
- MR223467L4
- MR224680
- MR224680L3
- MR224680L4
- MR225099
- MR225099L3
- MR225099L4
- RC205376
- RC205376L1
- RC205376L2
- RC205376L3
- RC205376L4
- RC226762
- RC226762L3
- RC226762L4
- RC226864
- RC226864L3
- RC226864L4
- RC229124
- RC229124L1
- RC229124L3
- RG205376
- RG226762
- RG226864
- RG229124
- RR209476
- RR209476L3
- RR209476L4
- RR215927
- RR215928
- RR215929
- MR223465L3V
- MR223465L4V
- MR223467L3V
- MR223467L4V
- MR224680L3V
- MR224680L4V
- MR225099L3V
- MR225099L4V
- RC205376L1V
- RC205376L2V
- RC205376L3V
- RC205376L4V
- RC226762L3V
- RC226762L4V
- RC226864L3V
- RC226864L4V
- RC229124L1V
- RC229124L3V
- RR209476L3V
- RR209476L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LMO2
- Addgene plasmids for LMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LMO2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for LMO2 Gene
- GeneLoc Exon Structure for
- LMO2
Expression for LMO2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Hemangioblasts Posterior Primitive Streak
- Primitive Erythrocytes Extraembryonic Blood Islands
- Hematopoietic Stem Cells Liver Bud
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Limb Bud Mesenchyme Cells Limb Bud
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Primitive Erythrocytes Extraembryonic Blood Islands
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Primitive Streak (Early Embryonic Tissues)
- Hemangioblasts Posterior Primitive Streak
-
Endothelium (Cardiovascular System)
- Hemangioblasts Posterior Primitive Streak
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Yolk Sac (Extraembryonic Tissues)
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Umbilical Cord (Extraembryonic Tissues)
- Lung (Respiratory System)
- NULL (Uncategorized)
- Cartilage (Muscoskeletal System)
This gene is overexpressed in Fetal Liver (48.0) and Placenta (21.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LMO2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LMO2
SOURCE GeneReport for Unigene cluster for LMO2 Gene:
Hs.34560Evidence on tissue expression from TISSUES for LMO2 Gene
- Nervous system(4.6)
- Kidney(4.5)
- Intestine(4.4)
- Blood(3.3)
- Bone marrow(3.2)
- Lymph node(2.8)
- Spleen(2.8)
- Heart(2.7)
- Liver(2.5)
- Muscle(2.4)
- Skin(2.3)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for LMO2
-
OriGene qPCR primer pairs and template standards for LMO2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMO2 Gene
Orthologs for LMO2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | LMO2 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | LMO2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LMO2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lmo2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lmo2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LOC609006 30 |
|
||
| LMO2 31 |
|
OneToOne | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LMO2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LMO2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LMO2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lmo2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | lmo2-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lmo2 30 31 |
|
OneToOne |
- Species where no ortholog for LMO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for LMO2 Gene
- ENSEMBL:
- Gene Tree for LMO2 (if available)
- TreeFam:
- Gene Tree for LMO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LMO2: view image
Paralogs for LMO2 Gene
Paralogs for LMO2 Gene
(16) SIMAP similar genes for LMO2 Gene using alignment to 1 proteins:
- RBTN2_HUMAN
Variants for LMO2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LMO2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 771440 | Benign: not provided | 33,859,497(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1115754 | CNV | insertion | 17803354 |
| nsv1069574 | CNV | deletion | 25765185 |
| nsv1118207 | CNV | deletion | 24896259 |
| nsv1147622 | CNV | insertion | 26484159 |
| nsv509398 | CNV | insertion | 20534489 |
| nsv519717 | CNV | loss | 19592680 |
| nsv526555 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LMO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LMO2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO2 Gene
Disorders for LMO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| t-cell acute lymphoblastic leukemia |
|
|
| severe combined immunodeficiency, x-linked |
|
|
| lymphoblastic lymphoma |
|
|
| ureteral lymphoma |
|
|
| t-cell lymphoblastic leukemia/lymphoma |
|
Search LMO2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RBTN2_HUMAN- Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
Genatlas disease for LMO2 Gene
acute lymphoblastic leukemia (T-ALL),with translocations t(11;14)(p13;q11),t(7;11)(p35;p13)
Additional Disease Information for LMO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
Publications for LMO2 Gene
- Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PMID: 16314316) Han C … Peng X (Nucleic acids research 2005) 3 4 23
- T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PMID: 9129143) Mao S … Goorha RM (Oncogene 1997) 3 4 23
- TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). (PMID: 1923511) Royer-Pokora B … Ludwig WD (Oncogene 1991) 3 4 23
- The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PMID: 2034676) Boehm T … Rabbitts TH (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 23
- Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes. (PMID: 20346173) Sun W … Zhu TH (Journal of biomedical science 2010) 3 23
ExternalLinks
Products for LMO2 Gene
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- Biorbyt antibodies for LMO2
Sources for LMO2 Gene
- (1) GeneCards
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