Aliases for LMO2 Gene
External Ids for LMO2 Gene
Previous HGNC Symbols for LMO2 Gene
Previous GeneCards Identifiers for LMO2 Gene
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
GeneCards Summary for LMO2 Gene
LMO2 (LIM Domain Only 2) is a Protein Coding gene. Diseases associated with LMO2 include Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Hematopoietic Stem Cell Differentiation and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is LMO1.
UniProtKB/Swiss-Prot for LMO2 Gene
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.