Aliases for LMO2 Gene
Aliases for LMO2 Gene
External Ids for LMO2 Gene
- HGNC: 6642
- Entrez Gene: 4005
- Ensembl: ENSG00000135363
- OMIM: 180385
- UniProtKB: P25791
Previous HGNC Symbols for LMO2 Gene
- RBTNL1
Previous GeneCards Identifiers for LMO2 Gene
- GC11M035411
- GC11M034557
- GC11M033919
- GC11M033844
- GC11M033836
- GC11M033576
Summaries for LMO2 Gene
-
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
GeneCards Summary for LMO2 Gene
LMO2 (LIM Domain Only 2) is a Protein Coding gene. Diseases associated with LMO2 include Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is LMO1.
UniProtKB/Swiss-Prot for LMO2 Gene
-
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Additional gene information for LMO2 Gene
- Monarch Initiative
- Search for LMO2 at DataMed
- Search for LMO2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO2 Gene
Genomics for LMO2 Gene
GeneHancer (GH) Regulatory Elements for LMO2 Gene
Promoters and enhancers for LMO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LMO2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LMO2 gene promoter:
-
- AML1a
Regulatory Element Products
Genomic Locations for LMO2 Gene
Genomic Locations for LMO2 Gene
- chr11:33,858,576-33,892,289
- (GRCh38/hg38)
- Size:
- 33,714 bases
- Orientation:
- Minus strand
- chr11:33,880,122-33,913,836
- (GRCh37/hg19)
- Size:
- 33,715 bases
- Orientation:
- Minus strand
Genomic View for LMO2 Gene
Genes around LMO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p13 by Entrez Gene
- 11p13 by HGNC
- 11p13 by Ensembl
LMO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LMO2 Gene
Proteins for LMO2 Gene
-
Protein details for LMO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25791-RBTN2_HUMAN
- Recommended name:
- Rhombotin-2
- Protein Accession:
- P25791
- Q9HD58
Protein attributes for LMO2 Gene
- Size:
- 158 amino acids
- Molecular mass:
- 18358 Da
- Quaternary structure:
-
- Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.
- SequenceCaution:
-
- Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH73973.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAA43430.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for LMO2 Gene
Protein Expression for LMO2 Gene
Post-translational modifications for LMO2 Gene
Other Protein References for LMO2 Gene
Antibody Products
- R&D Systems Antibodies for LMO2 (LMO2)
- Novus Biologicals Antibodies for LMO2
- Invitrogen Antibodies for LMO2
- GeneTex LMO2 Antibody for LMO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for LMO2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for LMO2
- Origene Custom Protein Services for LMO2
- GeneTex Proteins for LMO2
Assay Products
No data available for DME Specific Peptides for LMO2 Gene
Domains & Families for LMO2 Gene
Gene Families for LMO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for LMO2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LMO2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25791- Domain:
-
- The second LIM zinc-binding domain interacts with KDM5A.
Function for LMO2 Gene
Molecular function for LMO2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
- GENATLAS Biochemistry:
- LIM domain only 2,rhombotin 2,involved in association with LMO1 (and others),in the formation of multimeric DNA-binding complex for the generation of hematopoietic lineages and angiogenesis (in mice)
Phenotypes From GWAS Catalog for LMO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 16314316 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IDA | 16314316 |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 16314316 |
| GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding | IDA | 16314316 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 16314316 |
Phenotypes for LMO2 Gene
- MGI mutant phenotypes for LMO2:
-
inferred from 4 alleles
- cardiovascular system phenotype
- nervous system phenotype
- neoplasm
- integument phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for LMO2:
-
- Decreased HPV16-GFP infection
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LMO2
-
CRISPR Products
-
OriGene CRISPR knockouts for LMO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LMO2
- genomics-online: gRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for LMO2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
- GenScript: Design CRISPR guide RNA sequences for LMO2
miRNA for LMO2 Gene
- miRTarBase miRNAs that target LMO2
Transcription Factor Targets for LMO2 Gene
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMO2
- genomics-online: shRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for LMO2
- VectorBuilder custom plasmid, inducible vectors for LMO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LMO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LMO2
- genomics-online: cdna clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- orf clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials Clones for LMO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LMO2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for LMO2 Gene
Localization for LMO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LMO2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IDA | 16314316 |
Pathways & Interactions for LMO2 Gene
Pathways by source for LMO2 Gene
1 BioSystems pathway for LMO2 Gene
1 KEGG pathway for LMO2 Gene
1 R&D Systems pathway for LMO2 Gene
Interacting Proteins for LMO2 Gene
Selected Interacting proteins:
P25791-RBTN2_HUMAN
ENSP00000257818
for LMO2 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for LMO2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | TAS | 1923511 |
| GO:0042789 | mRNA transcription by RNA polymerase II | IDA | 16314316 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 16314316 |
| GO:0097067 | cellular response to thyroid hormone stimulus | IDA | 19375645 |
| GO:1902036 | regulation of hematopoietic stem cell differentiation | TAS | -- |
Transcripts for LMO2 Gene
mRNA/cDNA for LMO2 Gene
- (11) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (151) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000257818 2294 bps (uc010rem.3)
- ENST00000395833 1687 bps (uc001mve.5)
- ENST00000411482 1519 bps (uc058agf.1)
- ENST00000464025 1550 bps (uc001mvc.5)
- ENST00000465614 869 bps (uc058agh.1)
Unigene Clusters for LMO2 Gene
- LIM domain only 2 (rhombotin-like 1):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LMO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LMO2
- genomics-online: gRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for LMO2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
- GenScript: Design CRISPR guide RNA sequences for LMO2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMO2
- genomics-online: shRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for LMO2
- VectorBuilder custom plasmid, inducible vectors for LMO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LMO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LMO2
- genomics-online: cdna clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- orf clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
- Applied Biological Materials Clones for LMO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
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| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
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| SP6: | |||||||||||||||||||||||||||||||
| SP7: |
Expression for LMO2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Hemangioblasts Posterior Primitive Streak
- Primitive Erythrocytes Extraembryonic Blood Islands
- Hematopoietic Stem Cells Liver Bud
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Limb Bud Mesenchyme Cells Limb Bud
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Hematopoietic Stem Cells Extraembryonic Blood Islands
- Primitive Erythrocytes Extraembryonic Blood Islands
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Primitive Streak (Early Embryonic Tissues)
- Hemangioblasts Posterior Primitive Streak
-
Endothelium (Cardiovascular System)
- Hemangioblasts Posterior Primitive Streak
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Yolk Sac (Extraembryonic Tissues)
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Umbilical Cord (Extraembryonic Tissues)
- Lung (Respiratory System)
- NULL (Uncategorized)
- Cartilage (Muscoskeletal System)
This gene is overexpressed in Fetal Liver (48.0) and Placenta (21.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LMO2 Gene
NURSA nuclear receptor signaling pathways regulating expression of LMO2 Gene:
LMO2SOURCE GeneReport for Unigene cluster for LMO2 Gene:
Hs.34560Evidence on tissue expression from TISSUES for LMO2 Gene
- Nervous system(4.4)
- Kidney(4.3)
- Intestine(4.2)
- Blood(3)
- Bone marrow(2.5)
- Lymph node(2.4)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for LMO2
-
OriGene qPCR primer pairs for LMO2
- genomics-online: primer clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMO2 Gene
Orthologs for LMO2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LMO2 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | LMO2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LMO2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Lmo2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Lmo2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC609006 33 |
|
||
| LMO2 34 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LMO2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LMO2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | LMO2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lmo2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | lmo2-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lmo2 34 33 33 |
|
OneToOne |
- Species where no ortholog for LMO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for LMO2 Gene
- ENSEMBL:
- Gene Tree for LMO2 (if available)
- TreeFam:
- Gene Tree for LMO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LMO2: view image
Paralogs for LMO2 Gene
Paralogs for LMO2 Gene
(16) SIMAP similar genes for LMO2 Gene using alignment to 1 proteins:
- RBTN2_HUMAN
Variants for LMO2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025412 | -- | 33,864,043(-) | C/G | intron_variant | |
| rs1000109210 | -- | 33,892,009(-) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000306348 | -- | 33,877,621(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000385660 | -- | 33,864,410(-) | G/C | intron_variant | |
| rs1000419347 | -- | 33,882,095(-) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv526555 | CNV | loss | 19592680 |
| nsv519717 | CNV | loss | 19592680 |
| nsv509398 | CNV | insertion | 20534489 |
| nsv1147622 | CNV | insertion | 26484159 |
| nsv1118207 | CNV | deletion | 24896259 |
| nsv1069574 | CNV | deletion | 25765185 |
| esv1115754 | CNV | insertion | 17803354 |
Residual Variation Intolerance Score:
44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LMO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LMO2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO2 Gene
Disorders for LMO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoblastic leukemia |
|
|
| t-cell leukemia |
|
|
| diffuse large b-cell lymphoma |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| combined immunodeficiency, x-linked |
|
|
Search LMO2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RBTN2_HUMAN- Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
Genatlas disease for LMO2 Gene
acute lymphoblastic leukemia (T-ALL),with translocations t(11;14)(p13;q11),t(7;11)(p35;p13)
Additional Disease Information for LMO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for LMO2 Gene
- Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PMID: 16314316) Han C … Peng X (Nucleic acids research 2005) 3 4 22 58
- T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PMID: 9129143) Mao S … Goorha RM (Oncogene 1997) 3 4 22 58
- The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PMID: 2034676) Boehm T … Rabbitts TH (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 22 58
- TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). (PMID: 1923511) Royer-Pokora B … Ludwig WD (Oncogene 1991) 3 4 22 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
Products for LMO2 Gene
- R&D Systems Antibodies for LMO2 (LMO2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for LMO2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for LMO2
- Origene Custom Protein Services for LMO2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LMO2
- Browse OriGene Inhibitory RNA Products For LMO2
- OriGene qPCR primer pairs and template standards for LMO2
- OriGene qPCR primer pairs for LMO2
- OriGene CRISPR knockouts for LMO2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LMO2
- GenScript: Next-day shipping of latest version cDNA ORF clones for LMO2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for LMO2
- GenScript Custom Assay Services for LMO2
- GenScript Custom overexpressing Cell Line Services for LMO2
- GenScript: Design CRISPR guide RNA sequences for LMO2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LMO2
- Sino Biological Human cDNA Clone for LMO2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LMO2
- Novus Biologicals lysates and proteins for LMO2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for LMO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LMO2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LMO2
- antibodies-online: Search results for 148 available LMO2 Antibodies ranked by validation data
- Compare Top LMO2 Antibodies
- antibodies-online: Search results for 3 available LMO2 Elisa Kits ranked by validation data
- Compare Top LMO2 Elisa Kits
- antibodies-online: Search results for 11 available LMO2 Proteins ranked by validation data
- Compare Top LMO2 Proteins
- GeneTex LMO2 Antibody for LMO2
- GeneTex Proteins for LMO2
- Santa Cruz Biotechnology (SCBT) Antibodies for LMO2
- Search Santa Cruz Biotechnology (SCBT) for LMO2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LMO2
- Horizon Cell Lines for LMO2
- genomics-online: cdna clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- orf clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- genomics-online: primer clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 189 available LMO2 gene related products
- Overview of 189 available LMO2 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LMO2
- GeneCopoeia miRNA 3'UTR Target clone products for LMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMO2
Sources for LMO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt